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By LC Campeau & Dani Schultz
The podcast currently has 42 episodes available.
Join Dani and LC as they peel back the layers on podcasting in chemistry. This insightful episode dives into their recently published Organic Letters editorial "Should You Start a Chemistry Podcast?" with special contributor and corresponding author Matt Horwitz from Synthesis Workshop sharing his unique perspective.
But that's not all - get ready for an artistic twist as Brendan Burkett from Chemscrapes reveals how he transforms chemistry concepts into visually striking designs for the chemistry community (including CEN!).
Whether you're an aspiring podcaster, a chemistry communicator, or just someone fascinated by the interplay of science and art, this episode promises an engaging exploration. Tune in for a candid discussion blending personal experiences, creative insights, and a passion for making chemistry more accessible to all. Don't miss this multimedia showcase!"
Time for the main course! Our #MerckChemistry hiring experts are dishing out more savory tips to help you get hired in pharma.
Looking to kickstart your career in the pharmaceutical industry? This episode is a must-listen! We have special guests Jamie McCabe Dunn, Val Shurtleff and our very own Dani Schultz - hiring managers in Discovery and Process Chemistry - to share insider tips. In part 1 we talk about building a rock-solid network, crafting a standout CV that gets noticed, and acing those crucial first interviews. We also answer listener questions submitted on LinkedIn. Whether you're a fresh grad or an experienced pro, our experts will give you the competitive edge to land your dream job in pharma!
Plus, stay tuned for Part 2 we tackle how to ace your job talk, prepare for interviews and steps to take after receiving an offer!
Alexandra Sun and Harrison Rose join the pod to share their work on a vision-guided automated liquid-liquid extraction (LLE) platform. That's right, before our robot overlords overtake us, they are going to help chemists and engineers with work-ups first! Even though it's often taken for granted, liquid-liquid extractions are part of virtually every chemical reaction for product isolation. Developing these unit operations is critical to chemists and engineers who design processes and Harrison and Alex's new tool can help expedite this. We also asked them for their secret to developing the best phase cuts! We learned a lot on this episode, and we hope you do too!
General Principles and Strategies for Salting-Out Informed by the Hofmeister Series - OPRD
Nadine Kuhl (process chemist) and Jacob Forstater (engineer and physicist) join the pod to share a pretty neat story that had its origins from a chemical catalog brochure advertising a new and green solvent called Cyrene. From that brochure blossomed a really amazing biocatalytic transamination to make a key chiral amine building block. In order to make this process more robust and tolerant of organic solvents, the team immobilized the transaminase enzyme and leveraged a Spinchem rotating bed reactor (we also had no idea what this was, but now we do) to make a robust process. We learned a lot on this episode, and we hope you do too!
Read the papers we discussed today:
Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene - Green Chemistry
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
Charles Yeung (@Charles_chem) joins the pod to share some of the latest results from a collaboration with Prof. Wickens' lab (@WickensGroup) at the University of Wisconsin Madison. In their latest paper published in Angewandte Chemie, they disclose a practical and general protocol for alcohol dehydrogenation - putting the Barton-McCombie on notice! The work was supported by a Merck post-doctoral fellow, Myriam Mikhael (@MyriaMikhael), who shares her experience as an industrial PDF.
Read the papers we discussed today:
Practical and General Alcohol Deoxygenation Protocol - ACIE
Translating Planar Heterocycles into Three-Dimensional Analogs by Photoinduced Hydrocarboxylation - ACIE
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
For our special Holiday extravaganza, Dani and LC share their holiday plans before diving into the cookie jar of questions from some of our favorite listeners!
So top off that nog and join us for a Holiday Snack!
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
For this month's episode, Dani and LC serve up a recently published
In this episode, Dani and LC share the importance of investing in non-canonical amino acid chemistry with #MerckChemistry scientists Amélie Dion and Dipa Kalyani. We discuss what drew them to pyridinium cross-electrophile coupling and how Professor Watson’s expertise enabled the extension of this chemistry towards amino acid and peptide diversification via lysine deamination. By leveraging Dipa’s expertise in Discovery and high-throughput experimentation (HTE) – the team was able to create reaction generality for range of pharma relevant heteroaryl halides.
Professor Watson shares her insights on how working outside one’s area of expertise spurs innovation and ultimately what made this collaboration so successful. Many aspects of this collaboration were unique, which included real-time data sharing with our Discovery colleagues in addition to the team being largely composed of women! #WomenInChemistry
Read the paper we discussed today here:
Diversifying Amino Acids and Peptides via Deaminative Reductive Cross-Couplings Leveraging High-Throughput Experimentation - JACS
Beyond 20 in the 21st Century: Prospects and Challenges of Non-canonical Amino Acids in Peptide Drug Discovery - ACS Med. Chem. Lett.
Are Heterogeneous Catalysts Precursors to Homogeneous Catalysts? - JACS
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
For this month's episode, Dani and LC go all in on Ni-catalyzed cyanations with Caleb Hethcox who recently published 2 papers on the topic - one with a phenomenal intern, Geraldo Duran-Camacho.
Caleb shares how the internal team first identified this challenge and the solutions they explored to replace precious metal catalysts for cyanation reactions! Ultimately, the team identified a Ni-catalyzed system (go base metals!) and depending on the application, different reduction conditions which led to the different publications. As part of Merck's Future Talents Program, Caleb was joined by Geraldo who came to Merck and worked in our laboratories on this project. In addition, Geraldo gives us some of his learnings and insights from the experience which will be of great interest to potential future interns who listen to this episode.
Read the paper we discussed today here:
Nickel-Catalyzed Cyanation of (Hetero)aryl Bromides Using DABAL-Me3 as a Soluble Reductant - Org. Lett.
Air-Tolerant Nickel-Catalyzed Cyanation of (Hetero)aryl Halides Enabled by a Green Reductant - J. Org. Chem.
Merck Future Talent Program
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
The podcast currently has 42 episodes available.