In this episode, we explore the pharmacologic management of hemostasis, focusing on how medications are used to either prevent clot formation or control bleeding. We’ll review the mechanisms of blood coagulation and differentiate between arterial and venous thrombosis to better understand how various drug classes—anticoagulants, antiplatelet agents, and thrombolytics—work in clinical practice. The discussion also highlights systemic hemostatic agents, including protamine sulfate and vitamin K, used as antidotes for heparin and warfarin overdose. Finally, we’ll examine the medical and nursing management of bleeding disorders such as hemophilia and von Willebrand disease, emphasizing factor replacement therapy, desmopressin, and aminocaproic acid. This episode equips nurses with essential knowledge for safely administering, monitoring, and educating patients on drugs that balance the delicate process of clotting and bleeding.