PharmaTalkRadio

The pipeline of adoptive T-cell therapies and other cell based immuno-oncology programs continues to expand with a number of modifications and improvements to the first generation programs. These platforms include improved spcificty and delivery - including non-viral platforms, targeting of multiple antigens, editing constructs, and a variety of strategies to address toxicity and the tumor microenvironment. This panel of experts, moderated by Dr Gbola Amusa, Chardan and recorded at the 5th annual Immuno-Oncology 360° Summit, will consider the major technical and clinical improvements to cell based IO therapeutics that will lead to more durable therapies and the ability to treat both liquid and solid tumors.

Panelists include:

Dr Robert Ang, Neon TherapeuticsDr Usman "Oz" Azam, TmunityMichael Dombeck, Precision BioSciencesDr Aiman Shalabi, GSK

Save the date for the 6th annual IO360° Summit on February 26-28, 2020 at the Crowne Plaza Times Square in New York City. Learn more at www.io360summit.com

This panel moderated by Dr Andrew Baum, Citi and recorded at the 5th annual IO360° Summit discusses the preparation of an IPO, straight licensing with the transition to a public company and decision making on prioritization within portfolios. 

Panelists include:

David Epstein, Flagship PioneeringDan Passeri, Cue Biopharma

Save the date for the 6th annual Immuno-Oncology 360° Summit on February 26-28, 2020 at the Crowne Plaza Times Square in New York City. Learn more at www.io360summit.com

In this talk recorded at the 5th annual IO360° Summit, Dr Charles Link Jr, Newlink Genetics, addresses how IDO changes the T-cell balance in the tumor microenvironment.

This talk addresses how:

IDO creates local immunosuppression by increasing T regulatory cellsIDO often works in concert with PDL-1 mediated immunosuppressionIDO mediated T-cell immunosuppression leads to poor prognosis in melanoma

Save the date for the 6th annual Immuno-Oncology 360° Summit on February 26-28, 2020 at the Crowne Plaza Times Square in New York City. Learn more at www.io360summit.com

In this podcast from the 2019 Immuno-Oncology 360° conference, Cello Health BioConsulting's EVP, Oncology Practice Head, Dr Jeff Bockman discusses deal-making and investments in the I-O space to see what can be learned about the expanding and shifting landscape of BioPharma and investor interest by examining who is placing what kinds of bets on which targets and modalities, at what stage and with what terms.

Additional topics include:

Where are the next big paradigm shifts going to be?Where is the next great target that will supersize foundational checkpoint therapy?

Join us for the 6th annual IO360° conference on February 26-28, 2020 at the Crowne Plaza Times Square hotel in New York City.

To learn more about the event, please visit IO360 2020.

Pharma Talk Radio producer, Valerie Bowling recently spoke with a young Alzheimer's patient, Jeff Borghoff. Jeff was officially diagnosed with Alzheimers in 2016 and is an active and patiionate patient advocate. Jeff generously shares his experience from diagnosis, to the experience of a clinical trial to his work in advocacy.

Jeff will be speaking at the Patients as Partners conference on June 29-30, 2020 in Philadelphia. For more information, visit theconferenceforum.org

We look forward to bringing you more podcasts featuring patient advocates and more on the topic of dementia.

Resources that Jeff recommends:

Alzherimer's AssociationAlzheimer's Congressional TeamAlzheimer's Association Early-Stage Advisory Group

In this podcast from the 2018 Mobile in Clinical Trials conference, Mohammad Ali, Global Head Digital Trials- Global Clinical Operations, Boehringer-Ingelhiem and Joe Dustin, Principal, Mobile Health, Medidata Solutions discussed the internal infrastructure that is required for the successful scaling of mobile/digital tools in clinical trials.

The discussion focuses on how to come to terms with the demand of data, understanding the skill set required to purposefully use the data and implementing an internal system to allow for efficient scaling of mobile trials.?

Mohammad Ali is returning to Mobile 2019 to lead an interactive group activity on creating a pathway for brainstorming the digital biomarker process.

Speakers: Mohammad Ali, Global Head Digital Trials- Global Clinical Operations, Boehringer-Ingelhiem

                  Joe Dustin, Principal, Mobile Health, Medidata Solutions

In this podcast from the 2018 Mobile in Clinical Trials conference, patient advocate, Cindy Geoghegan sat down with Dr Daniel Karlin, CEO, Healthmode and Deanna Lennon, Director of Business Development, Medable Inc for a discussion on aligning the promise of technology with the patient voice.

The panel explores patient perspective on being monitored continuously and pharma perceptions of what patients want versus what patients really want.

Speakers: Cindy Geoghegan, Patient Advocate

                  Daniel Karlin, MD, CEO, Healthmode

                  Deanna Lennon, Director of Business Development, Medable Inc

In this podcast from the 2018 PODD: Partnership Opportunities in Drug Delivery conference, Dr Christopher Kovalchick, Chief Engineer, Drug Delivery & Devices R&D Innovation at Eli Lilly and Company presented on incorporating of digital monitoring biomarkers into drug delivery.

More specifically a framework is presented which stratifies key components and advances the concept of contextualized biomarkers. The framework codifies how direct, indirect, composite and contextualized composite data can drive innovation for the application of digital biomarkers in healthcare. In addition, application in disease and wellness is highlighted and incorporation in clinical feedback loops and closed-loop systems is illustrated. 

Dr Kovalchick is returning to PODD 2019 to present on Achieving the Ultimate Outcome for Patients- Utilizing Digital Health Data to Improve Disease Management, Prevention and Overall Wellness.

The 9th annual PODD conference with take place October 7-8, 2019 in Boston, MA. Learn more at theconferenceforum.org

In this podcast, Valerie Bowling, Director of PODD, walks you through what to expect at PODD 2019 in under 4 minutes. The 9th annual PODD conference features the following:

Building a Company around a Transformative Drug Delivery Invention with MIT's Dr Robert Langer, Dr Sangeeta Bhati, Dr Giovanni Traverso and Harvard Medical School's Dr Jeffrey Karp.Modality Fluid Development: Tales of Evolving Pipelines and Drug Delivery Solutions with Merck's, VP, Pharmaceutical Sciences, Dr Allen TempletonGene Therapy Keynote with Spark Therapeutics, President and Head of R&D, Dr Katherine HighZeitgeist Presentation on Immune Targeting Nanomedicine by AstraZeneca’s, VP, External Innovation and Novel Product Technologies, Dr Anand SubramonyConference Chair opening remarks provided by AstraZeneca's, Dr Shawn Davis

Additional Featured Speakers:

Roche’s, Senior Portfolio Strategy Director, Dr Beate Bittner will moderate the Formulation & Device Lifecycle Management for Biotherapeutics – Clinical and Industry Perspectives on Subcutaneous Delivery panel.Drug Delivery Pipeline and Technologies, A Year in Review, with Pharmacircle’s, VP, Kurt SedoDelivering Flexible Dosage Forms with Pfizer's Dr Advait Badkar

The 9th annual PODD conference will take place on October 7-8, 2019 in Boston, MA. Learn more at theconferenceforum.org

It is estimated that between 7-10 million people, globally have Parkinson's disease.  Our guest on Pharma Talk Radio, Lesley Gosden is living with Parkinsons and she is an outstanding patient advocate, who experienced the GDNF clinical trial. In this podcast discussion, our guest will give us an insight into living with Parkinson's, about the GDNF clinical trial, lessons for all stakeholders and in particular how the success rate of clinical trials could be improved from the patient’s point of view. 

Ms Gosden will be the Keynote patient advocate speaker at the Patients as Partners EU conference taking place in London on January 27th and 28th and for more information, visit theconferenceforum.org. 

Guest: Lesley Gosden, Patient Advocate

Host: Valerie Bowling, Producer, Pharma Talk Radio

For more information about the GDNF Trial: Reflections on the GDNF Trial