Ashok Krishnamurthi, Managing Partner at Great Point Ventures, says the biggest mistake in venture capital is confusing prediction with judgment.
Early stage investing is not about perfect stories, it is about first principles and picking the founder who can execute when the story breaks.
This episode is for startup founders and investors who want a cleaner filter for what matters.

“You have to learn to check your ego at the door because it’s a partnership.”

Ashok shares his path from engineering into building companies, then into venture capital, and explains how he forms an investment thesis when markets are noisy. We talk about founder evaluation, why picking the jockey matters more than the idea, and how first principles thinking shows up in real domains like healthcare data and cancer. We also get practical about artificial intelligence, why AI is not only a compute race, and how AI inference, energy efficiency, and cost shape what wins.

00:00 Why legacy matters more than VC metrics02:28 Engineer to founder to venture capital11:16 How to pick the jockey14:21 First principles, cancer data, and AI constraints23:24 AI is here to stay, keep your mind open30:15 How to reach Ashok

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