Point of care ultrasound (POCUS) can range in complexity from very basic exams to those that are expert level in nature. While some basic wall motion abnormalities are taught in many introductory classes, the concept of regional wall motion abnormalities (RWMA) for myocardial infarctions (MIs) can be a little more complicated and as a result is often not taught to novice learners of POCUS. Some have questioned the validity of the results, as well. In this post, we will cover some highlights including recent evidence that may further support the potential role of RWMA in MIs.