Podcast 440: Panaceum and a Healthy Microbiome – Part 2

Spencer Feldman from Remedy Link joins Martin Pytela to talk about his new product called: Panaceum. In this two part series, we will discuss the microbiome in great detail.

Today in Part 2, we discuss the microbiome in further detail. We explain how having a healthy microbiome may be the solution to many of our common health problems, while including some of Spencer’s personal experiences with the product.

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MARTIN: Hi, this is Martin Pytela for Life Enthusiast podcast, with me Spencer Feldman. This is our part two deep dive into microbiome. This will get technical. So those of you who have complex problems or need to explain something to your doctor, because your doctor has not gone to school to learn about microbiome. Unless he or she’s very active on reading the thousands of studies that have been coming through. Microbiome is the most studied aspect of human body aspects of late. Anyway, here’s Spencer Feldman. Let’s dive in.

SPENCER: Hey Martin. All right, let’s get to part two.

MARTIN: Yep.

SPENCER: So, you know, in part one, we talked about what the microbiome was, how we lost it, how we gain it back again, some tricks the trade of what you can do to get a good microbiome. The main of which is just feeding it properly. So now let’s talk more about some of the things that go into a deeper dive. First off microbiomes are everywhere in the body. It was previously thought that there were five primary microbiomes, the gut, mouth, skin, vagina, and sinuses, with the gut being the largest, comprising 90% of the bacteria in the body. We now know there’s a microbiome in the liver, the gallbladder, the brain, the lungs. And I’m confident that in time we’ll find a microbiome in every organ of the body. And when these microbiomes are fed with a variety of different oligosaccharides and are healthy, they protect the organs they live in from infections as well as participate in regulating their function.

SPENCER: However, when we don’t feed our microbiome, then there are only three outcomes. Dormancy, death and phenotype drift for the bacteria and the microbiome. So let’s talk about these. Another name for dormancy is hibernation and bacterial cells that hibernate are called persister cells. When bacteria run out of oligosaccharides to eat, they can simply go to sleep. And as soon the oligosaccharides return, they wake up again. This is a great strategy for the microbiome. After all, even successful hunter-gatherers, don’t always get food. They might be injured or get sick or have bad weather, or just bad luck for a few days.

The issue is if we don’t supply our microbiome with an adequate supply of oligosaccharides for more than a short time, the dormancy process can cause problems. When bacteria go dormant, they trigger the release of compounds of polyphosphates and bradykinin which increase membrane permeability, and lead to a leaky gut and leaky blood brain barrier.

SPENCER: And we’re going to get more about into those two. But one thing to know is the same process that causes a leaky gut also causes the blood brain barrier to leak. The second result of a lack of oligosaccharides is that bacteria can just die. Not all bacteria are good at going dormant, and even those that can hibernate have to wake up eventually. And if there’s still not enough food for them, they can just die.

And then the third outcome is phenotype drift.