Welcome to episode 92 of the Audio PANCE and PANRE physician assistant/associate board review podcast.

Today is part two of this extraordinary five-part series with Joe Gilboy PA-C, all about cardiac murmurs. In this week’s episode of the Audio PANCE and PANRE podcast, we continue our discussion of cardiac murmurs with a focus on the mitral valve.

We’ll talk about the different types of murmurs (stenosis and regurgitation) that can occur with this valve and how to differentiate them from other types of murmurs. If you haven’t already, make sure to listen to our previous podcast episode where we covered the aortic valve murmurs.

The mitral valve is located between the left atrium and the left ventricle in the heart. It consists of two leaflets (or cusps) and is responsible for preventing blood from flowing back into the atrium when the ventricle contracts.

The mitral valve can have two types of murmurs: stenosis and regurgitation.

In addition to auscultation, you can also look for certain signs and symptoms that may indicate mitral stenosis or regurgitation. For example, if a patient presents with chest pain (angina pectoris), this could be from decreased oxygen supply due to poor cardiac output in cases of significant stenosis. On the other hand, if a patient presents with an irregular heart rate (arrhythmia), this could be from increased electrical conduction velocity in cases of significant regurgitation.

Also, keep in mind that mitral valve disease can also occur secondary to rheumatic fever or endocarditis, so you may need to consider these diagnoses if a patient has any of the aforementioned signs and symptoms.

Below is a transcription of this podcast episode edited for clarity.

Welcome, everybody. This is Joe Gilboy, and I work with Stephen Pasquini at Smarty PANCE.

Today we’re back to the heart murmur podcast, and we just finished the aortic valve. The next one up is the mitral valve.

Let’s just look at this my way. In school, you memorize a bunch of facts, then someone asks a question about mitral stenosis or mitral regurgitation, and you are completely lost. It’s time to change that. Now, we are going to do it my way. Are you ready? Here we go.

Let’s look at the mitral valve on a normal day. What’s the mitral valve doing?

Let’s start with the first heart murmur, mitral stenosis. Think about it. Slow down and give this some thought.

I’ve got the stenotic mitral valve. See it? It can barely open. It’s like, man; you’ve got to push hard to open this door. So, you are the left atrium, and you’re pushing down on this stenotic mitral valve. It’s like, man; this is hard to open up! I have to push harder. Yes, you do!

Wait for a second; then I’m going to put more blood flow back against my left atrium? Completely correct. So, my left atrium might hypertrophy? Yes, that’s correct!

So, you’re telling me I might get left atrial hypertrophy with mitral stenosis? Exactly!

Now, think about it. There you are in the left atrium pushing against the mitral valve during stenosis that’s supposed to open during diastole. You’re just taking longer to open up. You see, in school, what you memorize is an opening snap. Remember that ridiculous graph where you saw it had S1, S2 on all those bar graphs? You thought you were reading a musical sheet. Do you remember that thing? Or you’re like oh, S1 S2 ……….!? You were looking at it thinking, ” I have no fricking idea what I’m looking at.” Let’s erase that.

Think about this for a second; if the left atrium is pushing on a stenotic valve, it’s going to have trouble during diastole. Because during systole, it has to be closed. It’s going to close without a problem.  The problem is opening it up. You can see the left atrium hypertrophy. Then blood flow may back up into the lungs and causes pulmonary hypertension.

Oh, wait for a second, I get pulmonary hypertension? Yes, you do!

Then maybe I have some fluid backed up in the lungs, and I might have a little shortness of breath and CHF. Exactly! Yes, that’s exactly how they’re going to present.

So, I have this diastolic murmur. It’s a diastolic ejection murmur to open that valve up. So, it’s not going to be an accentuated S1. But that’s not what they’re going to say on your boards, are they? No, that’s just a buzzword.

What they’re going to say is, “I have this diastolic rumbling murmur.” Rumbling means I’m trying to open up, and I’m going to radiate down towards the apex. That just makes logical sense.

So, I have this diastolic murmur radiating to the apex. Let’s take a closer look at the mitral valve. Remember, your heart doesn’t sit flat. It sits tilted and towards the back. So, I need this mitral valve to get towards the front. Okay, well, then tilt yourself to the left and lay down. Oh! That’s that left lateral to decubitus position they keep talking about. I’m going to bring it closer to the front.

Oh, that makes sense. I totally see that. So, I have a diastolic murmur that radiates to the apex. I can hear it better if I lay down on the left lateral decubitus position because that will bring the valve closer to the chest. Let’s make it sound louder now.

Okay, one more time back to how we were in the beginning with the aortic valve. Okay, what’s your party maneuver? Oh, I want to party, and I want to bring all the blood flow back home. How do you party? Oh, I squat. Squatting is a party. So, what are you going to do if I squat? How’s mitral stenosis sound? Louder! I get more blood flow pushing against the stenotic valve.

If I perform low-volume maneuvers, which are standing and Valsalva, I get less blood to the heart. Hi, standing and Valsalva, what’s going to happen to mitral valve stenosis. Yes, it’s going to go away!

Inspiration right (louder), and expiration left (louder). Repeat: inspiration right and expiration left. Hi, I have mitral stenosis! Oh, he’s on the left. What’s going to make him sound louder? Expiration? Yes, exactly!

Now, does everyone see this? So, you see, they’re not going to give you that “opening snap” buzzword.  All the buzzwords on the PANCE are gone, guys, so just throw them away. What they’re going to give you is some person with a heart murmur, who maybe has a little CHF, has a diastolic murmur, and that’s it. That’s all they’re going to give you now. What you have to think is diastolic: left side, going back to the lungs = stenosis. That makes perfect sense. And that’s mitral stenosis. So, the “open snap,” those buzzwords are gone.

Let’s review one more time:

There you go, that’s mitral stenosis.

Then there’s mitral valve regurgitation. I want you to view mitral regurgitation as “come and go as you please.”

This is a valve that won’t close. Repeat, “come and go as you please.” Let’s review the mitral valve again. “Hi, I’m diastole, I’m the left atria, and I’m coming through a valve that doesn’t care. Do you have any problems? No, I’m supposed to be open. So, I’m coming through during diastole not a problem.”

Now, let’s compare that to systole: “Hi, I’m systole and that mitral valve is supposed to be closed.” But is it going to be closed? Nooo. In systole, blood is coming and going as it pleases. So, wait for a second, then I’m going to be a systolic murmur. 100% correct. And are you having any resistance? Zero.

That’s why we call it a holosystolic murmur. Understand? And now I’m going from the apex at the bottom of the heart, and I’m radiating to the axilla. So, you’re going back up to the left atrium? Exactly.

So how is your blood flow out to the rest of the world? Not that good. Not good at all. So how are you feeling? I’m feeling a bit lightheaded (syncope) and short of breath.

Now let’s go one step further. Remember that LAD, the Windowmaker? Okay, if you look at the left anterior descending artery, it bifurcates into the left anterior descending and septal branches. Both these guys feed the chordae tendineae. It’s that octopus-looking muscle that pulls the mitral valve down. So now think about this for a second. Just give us some thought. Ready?

You just had a LAD MI. You’re in the hospital. The cardiologist has just put down a stent. You’re on the heparin drip. You are getting ready to go home, maybe on Xarelto or Eliquis. Right.

So, there you are, on a blood thinner. Can I ask you a question? Just give it a thought. You know, your chordae tendineae? You know, during the MI, remember that? Yes, your lacking blood flow to the left ventricle, weren’t you? Yes. How was your blood flow to your chordae tendineae? Yes, it was diminished.

Let’s review. The patient is in the hospital and on an IV beta-blocker (you want to rest the heart). Well, they’re going home and back to activities like walking through Costco or Walgreens, or CVS. He’s no longer on a beta-blocker, folks. His heart rates back up.

Is this chordae tendineae ready for normal heart rate? Yes, or no? No, not at all. He’s on the injured reserve list as well. And guess what? His chordae tendineae is not going to hold very well. He says, “Oh my god, I’m so weak. I can’t hold the mitral valve down”. Which means it is going to open back up.

That’s the test question you will see about post the MI patient who comes in two to four weeks later. The patient who’s got a new-onset murmur. What does he have? He’s got mitral regurgitation because his chordae tendineae got hypoxic during the MI, and now he’s got the murmur. So that’s a question that you see on Rosh Review, Hippo, Smarty PANCE, UWorld, and Kaplan. You’ll see this question rear its head, but the root of what they’re really after is something else. They want you to understand that the chordae tendineae itself was actually lacking blood flow during the LAD or ischemic event. So, it’s weakened. As soon as the patient goes to stress it out, it’s not going to work very well. It’s going to give way, and the chordae tendineae will rupture. What you have is mitral valve regurgitation. Does everybody see this?

This is the test question you’re going to get. An immigrant comes in with a diastolic murmur and shortness of breath. We don’t have the best testing for strep. Remember rheumatic fever? They are in their 30s and 40, and they’ve had rheumatic fever in the past, with mitral stenosis, and now the fluid is backing up to the lungs. That’s why they have shortness of breath.

And that’s the point I’m trying to make about the mitral valve. Does everybody see that now?

When you get the test questions, stop and think. You’re going to laugh because one of the things I tell all my students to do all the time is to try to make sense of it. See, what you guys do is memorize these things, and you run into your, what I call your data closet. I call it a closet full of data.

You get into this data closet, and what happens is you get lost in the closet. You say to yourself, “Okay, diastolic murmur, axilla blah, blah, blah, what did I memorize? Let me write down my little mnemonic. Yes, yes. Oh, man, I can’t Oh, man.” Next, you’re just panicking. And you just choose A, B, C, or D.

You say to yourself, “oh my god, I think I got the question wrong.” Exactly.

So next time, just try making sense of it.

So, we did the aortic valve, and we did the mitral valve. So, we did everything on the left. Next week, we are going to the right folks. We’re going to go to the pulmonic valve and the tricuspid valve.

So, one more time, guys. Inspiration right, expiration left. Inspiration right, expiration left. To make the right side of your heart murmur sound better, what are you going to do? Inspiration, so pulmonic and tricuspid sound louder with inspiration.

Expiration left. Who sounds better on the left? Aortic and mitral!

It’s been an honor and a pleasure talking with you today. I hope this makes more sense. Next week we’ll do the pulmonic valve. Till then, be good to yourself and take care.

Joe Gilboy PA-C

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Featured Image attribution (aortic stenosis and regurgitation): Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014“. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. Crop by Stephen Pasquini PA-C, CC BY 3.0