Prairie Rose Seminole is a citizen of the Three Affiliated Tribes of ND, descendant of the Sahnish/Arikara, Northern Cheyenne and Lakota Nations.

Seminole serves as a political consultant and coach, and policy analyst. They also serve as an Indigenous theological advisor and speaker. More recently,Prairie Rose Seminole served as the American Indian Alaska Native Program Director for the Evangelical Lutheran Church in America, serving American Indian, Alaska Native communities around the United States as an educator, and advocate, deconstructing colonial systems of oppression.

Seminole lives and works from White Shield ND, with her partner, their ten horses and seven country dogs.

Seminole has served on the Fargo Human Relations Commission in Fargo, the Midwest Advisory Council to the Federal Reserve Bank of Minneapolis and currently sits on the advisory council to the Olamina Fund and the boards for Humanities North Dakota, I Vote For, the Midwest Advisory Council for the Innocence Project, board member for the Native American Coalition of North Dakota.