Proactive - Interviews for investors

Intensity Therapeutics CEO Lew Bender joined Steve Darling from Proactive to announce a significant milestone: the first U.S. patient has been dosed in the company's pivotal Phase 3 clinical trial for treating metastatic sarcoma. This global superiority study is designed to evaluate the efficacy of INT230-6, a novel therapeutic agent, as a monotherapy compared to the investigator's choice of three standard-of-care systemic chemotherapy drugs. The trial focuses on second or third-line treatment for patients with metastatic, recurrent, or inoperable soft tissue sarcomas (STS).

Bender highlighted that the Phase 3 trial aims to enroll approximately 333 patients worldwide, with the primary endpoint being overall survival. The study is structured so that for every three patients enrolled, two will receive INT230-6, and one will receive the current standard of care. The trial specifically targets STS subtypes including leiomyosarcoma, liposarcoma, and undifferentiated pleomorphic sarcoma.

This Phase 3 study follows promising data from Intensity Therapeutics' earlier Phase 1/2 trial, where INT230-6 demonstrated significant tumor-killing and immune-activating properties, leading to increased survival rates in patients with metastatic disease.

Soft tissue sarcoma is a rare and challenging type of cancer that originates in the body's soft tissues, such as muscles, fat, blood vessels, nerves, tendons, and the linings of joints. The disease most commonly affects the arms, legs, and abdomen. In the United States, approximately 197,000 patients are living with sarcoma, which encompasses more than 50 different subtypes. Initial treatment typically involves surgery, but the recurrence or metastasis of the disease often necessitates additional therapeutic approaches, underscoring the importance of new treatment options like INT230-6.

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Ideal Power CEO Daniel Brdar joined Steve Darling from Proactive to discuss the company's exciting strides in the semiconductor industry, particularly their expanding presence in the electric vehicle market. A significant milestone for Ideal Power is their engagement with a third global automotive manufacturer, which is exploring the integration of the company's state-of-the-art semiconductor technology into its EVs.

Brdar highlighted the distinct advantages of Ideal Power's silicon-based semiconductors, which are designed to reduce energy losses more effectively than competing materials. This innovation is crucial for automakers who are grappling with the challenges of high costs and limited driving range in electric vehicles. By adopting these advanced semiconductors, manufacturers can significantly enhance the efficiency and performance of their EVs, making them more competitive in the rapidly growing market.

In addition to this new partnership, Ideal Power has already secured strategic collaborations with automotive giants Stellantis and another top ten global automaker. These relationships not only underscore the company's technological leadership but also position Ideal Power for substantial growth in the automotive sector. Brdar expressed confidence that these partnerships will accelerate the adoption of their semiconductor solutions across a broad spectrum of EV applications.

Brdar also touched on Ideal Power's collaboration with RYOSHO USA, a strategic partnership that bolsters the company's reach within the global semiconductor market, with a particular focus on Asia. This alliance is set to enhance Ideal Power's market penetration and distribution capabilities in one of the world's most dynamic and fast-paced regions for semiconductor technology.

According to Brdar, Ideal Power is well-positioned for sustained success, thanks to its innovative technology, robust intellectual property (IP) portfolio, and expanding network of global manufacturing partners. He emphasized that the growing demand for EVs, renewable energy solutions, and EV charging infrastructure creates a highly favorable environment for Ideal Power's cutting-edge products.

Looking ahead, Brdar is optimistic about the company's future, noting that Ideal Power is not only meeting current market needs but is also poised to play a pivotal role in shaping the next generation of energy-efficient technologies. With strong partnerships, a clear growth strategy, and a commitment to innovation, Ideal Power is on track to become a key player in the global semiconductor and EV industries.

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C3 Metals CEO Dan Symons joined Steve Darling from Proactive to share shared significant updates with Proactive regarding the company's advancements at its Khaleesi porphyry and skarn copper-gold project located in Southern Peru. A pivotal development has taken place with the execution of a surface access rights agreement with the Cancahuani community, a crucial step that paves the way for further exploration activities.

The Khaleesi project stands out as a highly promising, yet undrilled, copper-gold skarn and porphyry prospect. Its strategic location within a region known for large-scale copper operations adds to its potential. Notably, the renowned Las Bambas and Constancia copper mines, both situated less than 45 kilometers away, share the same district as Khaleesi. These mines are known for their expansive porphyry-skarn complexes, which exhibit geological features and surface expressions strikingly similar to those found at Khaleesi.

Symons emphasized that securing surface access was the critical hurdle needed to advance the Declaration of Environmental Impact, a key component in moving the project forward. With the surface access rights now secured, C3 Metals has successfully completed the CIRA process, which confirmed the absence of archaeological remains within the project area, further clearing the way for exploration.

Given its proximity to other large-scale copper mines and its similar geological setting, the Khaleesi project has always been regarded as one of the most promising assets in C3 Metals' portfolio. Now, with this essential agreement in place and the remaining permitting steps being largely procedural, the company is well-positioned to explore strategic options more effectively. This development not only enhances the value of the Khaleesi project but also allows C3 Metals to consider various avenues for advancing their exploration activities in both Peru and Jamaica.

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Ethernity Networks Ltd (AIM:ENET, OTCQB:ENETF) vice president of marketing and business development, Ilan Tevet, talked with Proactive's Stephen Gunnion about the company’s latest milestones.

The company has secured a $200,000 deal with a leading American broadband systems provider. Under the contract, Ethernity Networks will enhance the customer’s product, maintaining its competitive edge in the market. Tevet shared details of their longstanding relationship with the US customer, which dates back to 2018, highlighting the deployment of thousands of remote 10Gb PON OLTs featuring Ethernity’s data processing semiconductor technology.

The enhancements are set to roll out in the second half of 2024, providing significant value to the customer through a new FPGA code firmware upgrade. This upgrade is expected to drive increased sales and additional revenues for Ethernity Networks in the coming years.

Additionally, Tevet revealed that Ethernity Networks' Link Bonding Solution has been shortlisted for the prestigious 'Outstanding Fixed Wireless Access Solution Award' at the upcoming Network X show in Paris. This innovative solution aggregates diverse connections into a reliable data transport pipeline, offering high-capacity broadband connectivity, particularly in underserved areas.

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atai Life Sciences co-founder and co-CEO Dr Srinivas Rao takes Proactive's Stephen Gunnion through the positive results from the Phase 1b trial for VLS-01, emphasizing its excellent tolerability and potential as a best-in-class treatment option. The trial revealed that the formulation exceeded expectations, particularly in terms of pharmacokinetics, with results comparable to intravenous administration.

VLS-01 is being developed for treatment-resistant depression, a condition that impacts the lives of an estimated 100 million people globally. Srinivas emphasizes the potential of VLS-01 as a best-in-class treatment option, with excellent tolerability, patient-friendly administration and a short 2-hour in-clinic treatment time. The trial revealed that the formulation exceeded expectations, particularly in terms of pharmacokinetics, with results comparable to intravenous administration.

Rao noted that the next steps include advancing the 120mg dose into a robust Phase 2 trial for treatment-resistant depression, with results expected by the end of next year. He also addressed recent FDA decisions regarding MDMA and how atai's approach in trial design avoids similar pitfalls.

Beyond VLS-01, Rao highlighted that the company is progressing its clinical development plans for EMP-01, which is oral R-MDMA, with a Phase 2 trial for social anxiety disorder set to initiate by the end of the year.

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London’s FTSE 100 has kicked off the day higher as the markets reacted positively to inflation increasing slower than analysts had expected.

ONS data showed a 2.2% uptick in inflation in the year to July, the first acceleration in 2024 and rising from 2% in May and June respectively, but below expectations for a 2.3% increase.

Analysts noted a lower-than-expected service inflation print, of 5.2% against analysts’ 5.5%, which could spell good news for further Bank of England rate cuts this year.

Meanwhile, Aviva shares have held flat after it unveiled a 14% increase in operating profit for the first half of the year. “Sales are up. Operating profit is up. The dividend is up. Our plan to deliver more for customers and shareholders is working really well,” said chief executive Amanda Blanc.

Blanc highlighted that Aviva added 270,000 more customers year to date.

Shares in FTSE 250 infrastructure group Balfour Beatty shifted lower despite it hiking its interim dividend after revenue and profit ticked up over the first half of the year. According to the group, the outlook for complex projects remains “encouraging,” despite a series of plans being scrapped under Britain’s new Labour government.

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Evion Group NL (ASX:EVG, OTC:EVIGF) managing director David Round joins Proactive’s Tylah Tully to discuss its strategy to obtain mining permits for the Maniry Graphite Project in Madagascar and plans to secure European Union funding under the Critical Raw Materials Act.

Madagascar's new mining code, adopted in late 2023, facilitates the granting of development and production licences for graphite projects. The Madagascan Ministry of Mines has instructed the Bureau du Cadastre Minier (BCMM) to start issuing or upgrading permits for mining operations.

The company has been invited to apply for EU project development funding, recognising graphite as essential for the energy transition. Round said Madagascar's new mining code and recent government actions, supported by the World Bank, are positive steps for unlocking the country's critical mineral resources.

Evion is working to secure the necessary permits and has noted strong local support for the Maniry project. The government began issuing mining permits on August 1, 2023, aided by World Bank investment. Several senior Madagascan government officials will visit Perth in September 2023 to attend the Africa Down Under Conference and participate in meetings concerning the growing importance of graphite.

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Lightning Minerals Ltd (ASX: L1M) managing director Alex Biggs joins Proactive’s Tylah Tully to discuss the company’s lithium pursuits in Brazil, as it enters into a binding exclusive call option agreement for the acquisition of the Esperança Project, located 5 kilometres south of its recently acquired projects in Minas Gerais, Brazil.

The agreement provides L1M with a 24-month option to acquire Esperança at a low cost, enhancing its land package in proximity to the Caraíbas and Sidrônio lithium projects. The decision was made following a site visit by Biggs, who confirmed the presence of pegmatite formations with potential for hard rock lithium mineralisation.

The Esperança Project, within the Salinas Formation which is known for its prolific lithium resources, adds potential to L1M's exploration portfolio. The company plans to extend ongoing exploration activities at Caraíbas and Sidrônio to include Esperança, aiming to identify drill targets.

The agreement terms involve an initial payment of A$13,500, with another A$13,500 due within 12 months, followed by monthly payments of A$32,400 over the 24-month period. If L1M proceeds with the acquisition, an additional A$270,000 will be paid, plus a A$540,000 bonus contingent on defining a significant mineral resource.

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Sprintex Ltd (ASX:SIX) managing director Jay Upton joins Proactive’s Tylah Tully to discuss its series of upcoming investor and broker briefings, highlighting its strategic progress and market outlook.

The company, known for its work in ultra-high-speed electric motors and clean air compressors, will focus on its revenue growth, product innovation, financial strength and partnerships in regions including China and Malaysia.

Sprintex is targeting 400% growth in the ultra-high-speed electric motors and clean air technology markets. The company has recently enhanced its Programmable Logic Controller (PLC) product, making it compatible with various industrial communication standards. This improvement facilitates smoother integration of its advanced technology blowers into larger systems.

Significant revenue growth is anticipated, particularly from the China market, with projections of A$14.75 million, supported by private labelling agreements and exclusive distributorships. The introduction of the G15 and G25 blower series reinforces Sprintex’s leadership in energy-efficient technology.

Financially, Sprintex aims for a market capitalisation of A$100 million by June 2025 and A$250 million by December 2026. The company is also expanding into clean energy, developing compressors and blowers for sustainable energy systems in collaboration with manufacturers in the United States and Europe.

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Tempest Minerals Ltd (ASX:TEM) managing director Don Smith sits down with Jonathan Jackson in the Proactive studio to discuss site preparations for a 5,000-metre reverse circulation (RC) drilling program at the Remorse target within the Yalgoo Project in Western Australia.

After significant delays due to unforeseen weather and flooding, the company has established safe access, allowing for the commencement of earthworks, including site access and drill pad construction. Drilling is expected to begin later this month upon completion of these preparations.

The Remorse target, on the eastern side of the Yalgoo Project, was chosen based on geochemical and geophysical anomalies identified during surveys. Tempest Minerals has interpreted a 4-kilometre area within this target as prospective for copper-zinc mineralisation.

The Yalgoo Project encompasses 1,000 square kilometres in the Yalgoo region, situated near notable operations such as 29 Metals Ltd’s Golden Grove mine, Spartan Resources’ Yalgoo Gold Project, Silverlake’s Deflector and Rothsay gold mines and Capricorn Metals’ Mt Gibson Gold Project.

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