Professor Misha Perouansky has developed parallel careers as an anaesthetist and an experimental neuroscientist. Multilingual in every sense of the word, his experience ranges widely across cultures and traditions. A passionate desire to interrogate his work deeply led led him into the history and philosophy of science. He is currently exploring responses to brain trauma through genetic research with fruit flies at his university of Madison, Wisconsin. In this conversation we explore our experiences of intersection between science and clinical practice.