Professor Salvador Moncada - Audio

Professor Salvador Moncada - Audio

By UCL
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Professor Salvador Moncada - Audio episodes

  • 1. Growing up in Central America
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    3 min
  • 23. Mitochondria: new ideas about the way cells use energy sources
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    4 min
  • 22. Mitochondria: nitric oxide as modulator of oxygen consumption
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    4 min
  • 6. Blood platelet function - why aspirin causes bleeding
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    3 min
  • 4. Prostaglandins and Aspirin - the importance of bioassay
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    5 min
  • 7. Discovering thromboxane synthase, and a new enzyme
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    4 min
  • 3. Professor Salvador Moncada - Starting work in John Vane's_laboratory, 1971
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    3 min
  • 24. Wellcome's important characteristics
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    3 min
  • 21. Septic shock
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    5 min
  • 20. Inflammation, rheumatoid arthritis and tissue damage
    From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin, which acts as an effective vasodilator and also prevents blood platelets from clumping. In 1980 came the discovery by Robert Furchgott of ‘endothelium-derived relaxing factor’ (EDRF) which causes smooth muscle in the vessel walls to relax. Moncada and his team showed that EDRF was, in fact, Nitric oxide, which has since become appreciated as a neurotransmitter, a modulator of inflammation and a sensor of cellular distress as well as a regulator of vessel tone. Nitric oxide is both the target and effector of a range of compounds now being used for the treatment of cardiovascular and rheumatic diseases. Professor Moncada was appointed Director of the Wolfson Institute for Biomedical Research at University College in 1995. He has won numerous awards from the international scientific community including a Dart/NYU Biotechnology Achievement Award, the Prince of Asturias Scientific and Technological Research Award and the Dr AH Heineken Prize for Medicine from the Royal Netherlands Academy of Arts and Science.
    5 min

About Professor Salvador Moncada - Audio

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From 1975 to 1995, Professor Moncada worked at the Wellcome Research Laboratories, first as Head of Prostaglandin Research and then as Director of Research. He described the structure of prostacyclin,…

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