The European Society for Medical Oncology (ESMO) 2021 Congress saw many exciting clinical trials presented from across the field of oncology, some of which are paving the way for new standards of care for patients. Among the biggest readouts for the field of prostate cancer were the STAMPEDE (NCT00268476), PEACE-1 (NCT01957436), and ARCHES (NCT02677896) studies. In this podcast, we are joined by Robert Jones, MD, PhD, from the University of Glasgow and Beatson West of Scotland Cancer Centre, Glasgow, UK, as he provides an overview of the biggest news in prostate cancer from ESMO 2021.