PSPod

On today’s episode, Mike Smith from Pfizer, Justin Wilkins from Occams, and Amy Cheung from AstraZeneca discuss “Thoughtflow”, a set of standards compiled by the DDMoRe consortium to help facilitate the capture, storage, and reporting of knowledge in the context of MID3, as well as to support reproducibility.

This episode features Dr. Iñaki F. Trocóniz discussing how pharmacometric techniques can be used to counteract immuno-response suppression by tumor cells. Read his commentary from the January 2017 issue here. Also, please find additional CPT:PSP articles related to this topic in the Immuno-oncology Virtual Issue, which is available here. Listen and subscribe for free on iTunes

This episode features Dr. Satyaprakash Nayak discussing application of advanced pharmacometrics and quantitative systems pharmacology in hematology. Read his article from the July 2016 issue here. Also, please find additional CPT:PSP articles related to hematology in the Hematology Virtual Issue, which is available here. Listen and subscribe for free on iTunes and Google Play

In this episode, Drs. Scott Marshall from Pfizer, Sandra Visser from Merck, and Amy Cheung from AstraZeneca discuss “Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation”: their White Paper published in the March 2016 issue of PSP. You can get free access the White Paper by clicking here. Listen and subscribe […]

In this episode, Peter Bonate from Astellas, discusses effective communication in systems pharmacology and pharmacometric models. You can read a review of Dr. Bonate’s book Be a Model Communicator and Sell Your Models to Anyone, reviewed by Ellen Leinfuss in the May 2015 issue, by clicking here. Listen and subscribe for free on iTunes and […]

This episode features Sandra Visser and Anne Chain from Merck & Co/MSD, discussing existing practice and modeling approaches and some thoughts with regard to future directions for modeling to assess and predict cardiovascular liabilities of new drugs. You can read Dr. Visser’s Review “Implementation of Quantitative and Systems Pharmacology in Large Pharma” by clicking here. […]

This episode features Lutz Harnisch from Clinical Pharmacology Pharmacometrics at Pfizer, discussing the Drug Disease Model Resources (DDMoRe) consortium. His Perspective article that introduces the activities of the DDMoRe consortium can also be found here. Listen and subscribe for free on iTunes and Google Play

In this episode, we interview Dr. Shiew-Mei Huang, Deputy Director, Office of Clinical Pharmacology, Center for Drug Evaluation and Research at the Food and Drug Administration about a drug interaction database–a tool for evaluating the impact of renal or hepatic impairment in a pharmacologic inhibition on the systemic exposure of drugs. Read the article here. […]

In this episode, we interview Dr. Steven E. Kern, Deputy Director of Quantitative Sciences at the Bill and Melinda Gates Foundation, about infectious diseases in context of the possibilities for pharmacometrics and systems pharmacology to contribute to improve treatments in the area. You can view PSP’s Infectious Diseases virtual issue online to view the most recently […]