Should some children be given drugs to stop them going through puberty?

That’s the question the NHS, the government and an independent research and ethics committee have been trying to answer.

The “Pathways” trial, backed by the NHS and led by a team from King’s College London, aims to test the effectiveness and safety of puberty blockers for children experiencing gender dysphoria.

At the end of 2025, the trial was approved to go ahead. Health Secretary Wes Streeting reassured parliamentary colleagues it “could not have received more oversight and scrutiny”. 

But now the agency in charge of medicine regulation has U-turned. The study is now paused because of ethical and safety concerns. All of which, Hannah Barnes reports today on the New Statesman website, they knew about when they first approved it.

So how did the study get approved in the first place? And what does this tell us about the systems we trust to ensure medical research is safe and ethical?

Also: Baroness Amos has released the interim findings from her review into England's maternity care, and says the system is "not working".

Oli Dugmore is joined by Hannah Barnes to discuss.

READ MORE

Inside the decision to pause the puberty blockers trial

England's maternity system "not working" for anyone, report says

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