In this shiur, delivered in Sharfmans, Rav Burg explains why:

1. We are not Yotzei when we read the Megillah backwards.

2. We are obligated to drink until we don't know the difference between Arur Hama and Baruch Mordechai.

Who would read the Megillah backwards? Why would we want to get so drunk that we can't distinguish between a Tzaddik and a Rasha?

Only when we let go of using knowledge as power and control do we come to accept reality as it is. And once we accept reality as it is it is quite possible that the exact thing we thought was hurting us was our greatest asset.