Welcome back to the RadOnc Smart Review Physics Series! In E15a, we covered brachytherapy sources and TG-43 dose calculations. In P15b, we looked at clinical applications and planning systems. Now, in our final brachytherapy episode, P15c: Brachytherapy QA, Safety & Regulations, we focus on arguably the most critical aspect: ensuring these procedures are performed safely and accurately, protecting both patients and staff, and complying with strict regulatory requirements.