Imagine a world where losing a tooth isn't permanent, and the solution isn't a painful implant or uncomfortable dentures. A groundbreaking new study published in Science Advances has identified a "brake pedal" gene called USAG-1 that stops our bodies from growing new teeth, and researchers have successfully used a targeted antibody to release this brake in mammals. By deactivating USAG-1, scientists were able to stimulate the growth of a "third dentition"—a completely natural, fully formed tooth—in both mice and ferrets, effectively unlocking a regenerative capability that may lie dormant in humans. This video dives deep into the mechanism of BMP signaling, the role of diphyodont biology, and the revolutionary potential of tooth regeneration therapy that could one day transform dentistry from drilling and filling to simple regrowth.

Watch on YouTube with subtitles: https://www.youtube.com/@whatthestudysays
Podcast: https://podcasts.apple.com/tw/podcast/what-the-study-says/id1814559387
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