Psychedelics are having a moment in medicine  but what do we actually know about how they work, and could they help an aging brain? In this episode, Dr. Dani Cabral talks with James Hosobe, a biomedical research analyst with a background in medicinal chemistry, pharmaceutical sciences, and psychedelic policy, to unpack the science, the hype, and the very real open questions around psychedelic-assisted therapy especially for older adults facing conditions like Alzheimer's and Parkinson's disease.

The conversation was sparked by patients and families reaching out after seeing news coverage of a woman with significant cognitive and functional impairment who reportedly improved after psilocybin use. Dr. Dani and James dig into why that single case report can't tell us what we want it to and what would actually need to happen for psychedelics to become a legitimate tool in brain health.

James Hosobe is a biomedical research analyst with the Arizona Department of Health Services, where his work spans preclinical and clinical research, psychedelic policy, and evidence-based public health. 

How to Find James Hosobe:

Linkedin: https://www.linkedin.com/in/hosobe

Instagram: https://www.instagram.com/5ht2andjames/ 

Resources Mentioned

• Roland Griffiths' Johns Hopkins research on psychedelic experiences Griffiths, R.R., Richards, W.A., McCann, U., & Jesse, R. (2006). Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology, 187(3), 268–283. Griffiths, R., Richards, W., Johnson, M., McCann, U., & Jesse, R. (2008). Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. Journal of Psychopharmacology, 22(6), 621–632.

• Robin Carhart-Harris's REBUS model (Relaxed Beliefs Under pSychedelics) Carhart-Harris, R.L. & Friston, K.J. (2019). REBUS and the anarchic brain: Toward a unified model of the brain action of psychedelics. Pharmacological Reviews, 71(3), 316–344.

• Michael Pollan, How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence (Penguin Press, 2018)

• Dr. Gül Dölen's research on the "critical period" (Johns Hopkins / UC Berkeley) — note: corrects the name mentioned in the episode audio, "Ben Gould Dolan," to Dr. Gül Dölen Nardou, R., Sawyer, E., Song, Y.J., et al., & Dölen, G. (2023). Psychedelics reopen the social reward learning critical period. Nature, 618(7966), 790–798.

• David Olson's work on non-hallucinogenic psychoplastogens (UC Davis) Cameron, L.P., Tombari, R.J., Lu, J., et al., & Olson, D.E. (2021). A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature, 589(7842), 474–479.

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In this episode, Dr. Dani sits down with Dr. Jeff Iliff, one of the pioneering scientists behind the discovery of the glymphatic system, the brain's waste clearance network that has transformed our understanding of brain health, sleep, and neurodegenerative diseases.

Dr. Jeff Iliff is the Associate Director for Research at the VA Puget Sound Health Care System's Northwest Mental Illness, Research, Education and Clinical Center (MIRECC) and the Arthur J. and Marcella McCaffray Professor in Alzheimer's Disease at the University of Washington School of Medicine.

Together, they explore how the brain removes harmful proteins, why quality sleep is essential for this process, and what happens when this system becomes impaired. The conversation also dives into groundbreaking MRI techniques that allow researchers to study brain clearance in humans, the long-term effects of traumatic brain injury (TBI), and how these discoveries may lead to earlier detection and future treatments for Alzheimer's disease and other neurological disorders.

This episode is a mind-blowing look at one of the most exciting developments in modern brain research.

How to Find Dr. Jeffrey Illiff:

Website: https://www.ilifflab.com/

Thread: @jeffreyiliff 

Email: [email protected]

Linkedin: https://www.linkedin.com/in/jeffrey-iliff-a528564/

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In this inspiring episode, we sit down with Bob Ehlers to explore his remarkable journey living with early onset Alzheimer’s while continuing to innovate, lead, and serve others. Bob shares how his diverse background in business, technology, and entrepreneurship shaped his perspective on aging, resilience, and legacy.

From executive leadership roles at global companies to founding startups and nonprofit initiatives, Bob discusses how he turned personal challenges into purpose-driven work through Conexo Casa, a nonprofit focused on supporting older adults and individuals with neurocognitive impairments through smart home technology and social connection.

Bob’s story is a powerful reminder that even in the face of uncertainty, we can continue creating impact, connection, and hope.

How to Find Bob Ehlers

App: https://conexo.casa/ 

LinkedIn: https://www.linkedin.com/in/bobehlers 

Invisible Man: https://www.youtube.com/watch?v=GNTp7_TDmdc 

Youtube: https://www.youtube.com/@BobEhlers_AZ

Soundcloud Playlist: https://soundcloud.com/robert-bob-ehlers/sets/first-act 

Dementia Alliance International: https://dementiaallianceinternational.org/

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This episode features Caleb Lihn, an elder law attorney Founding Partner of Lihn Law Group, and Jenny Krulwich, a licensed social worker, discussing the importance of proactive planning for aging and cognitive health. 

Caleb Lihn is a Certified Elder Law Attorney and Founding Partner of Lihn Law Group focusing on elder law, estate planning, disability and special needs planning, and probate. Caleb graduated from Arizona State University and earned a J.D. from University of the Pacific, McGeorge School of Law. After two direction-changing family issues, a mother with progressive cognitive issues and a daughter born with a significant congenital heart defect. He returned to law school and earned an LL.M. in Estate Planning and Elder Law. He serves on several boards and is an Adjunct Professor of Law at Western New England University, College of Law.

Jenny Krulewich is motivated to utilize person centered practices, empathy, and humor to assist families and individuals with enhancing quality of life when faced with unexpected challenges. Jenny graduated from the University of Iowa with her bachelor’s in social work and from the University of Illinois at Chicago with her master’s in social work. Jenny’s career in social work began as a private care manager and guardianship representative serving individuals of all ages with developmental, intellectual, and physical disabilities. 

They share insights on legal documents, capacity assessments, and holistic care strategies to support families through complex aging journeys.

The Lihn Law Group Elder Care & Legal Symposium is this Thursday, April 16, from 8:00 a.m. to 4:00 p.m.  Register at https://lihnlawgroup.com/elder-care-and-legal-symposium/.

How to Find them:

Instagram: https://www.instagram.com/lihnlawgroup/ 

Facebook: https://www.facebook.com/lihnlawgroup 

Website: https://lihnlawgroup.com/ 

Resources:

Arizona Attorney General's Office - Power of Attorney Forms - https://azag.gov/

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In this episode, Dr. Dani Cabral sits down with Dr. Esra Shermadou, MD, a board-certified Family Medicine and Obesity Medicine physician and founder of Sakinah Health, a direct patient care clinic in Dayton, Ohio.

In this thoughtful conversation, Dr. Shermadou shares how her own health journey shaped her perspective on medicine and wellness. After being diagnosed with cancer at just 21 years old and undergoing chemotherapy, she developed a deep appreciation for movement and rebuilding strength. What began as a path to recovery eventually sparked her passion for strength training and long-term health.

They explore why muscle health is one of the most important and often overlooked pillars of longevity. They discuss how strength training supports metabolic health, helps prevent insulin resistance, promotes brain health through the release of beneficial myokines and BDNF, and builds the physiological reserve our bodies need to recover from illness or injury as we age.

They also talk about how the direct patient care model allows physicians to slow down, listen more closely, and create personalized care plans that truly support patients’ long-term health goals.

If you’ve ever wondered how to live not just longer, but stronger, this episode offers powerful insights on muscle, longevity, and the importance of whole-person care.

How to Find Dr. Esra Shermadou,MD

Website: https://www.drshermadou.com/ 

Facebook: https://www.facebook.com/esra.shermadou 

Linktree: https://linktr.ee/drshermadou 

Instagram: https://www.instagram.com/dresrasgottheiron 

Youtube: https://www.youtube.com/@dresrashermadou 

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What happens when a life rooted in music evolves into a life devoted to caring for people at the very end of theirs?

In this deeply moving conversation, Dr. Dani Cabral talks with Dr. Maribeth Gallagher—psychiatric nurse practitioner, hospice leader, and former professional singer who came of age in the vibrant 1970s San Francisco music scene. Her journey from stage to bedside reveals something profound: music is not just entertainment. It is a pathway into connection, identity, and humanity, even in the final moments of life.

Drawing from decades of experience in hospice and dementia care, Dr. Gallagher shares how music can reach people when words no longer can, awakening presence, evoking memory, and creating moments of joy and recognition in even the most advanced stages of illness.

This episode is about more than music. It’s about what remains when so much is lost, how we connect beyond language, and what people at the end of life teach us about how to live.

How to Find Dr. Maribeth Gallagher

Website: https://hov.org/ and https://dementiacampus.org/

Email: [email protected]

Facebook: https://www.facebook.com/HospiceoftheValley/ 

LinkedIn: https://www.linkedin.com/company/hospice-of-the-valley/ 

Instagram: instagram.com/hospiceofthevalleyaz 

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Dr. Dani Cabral speaks with Dr. Cindy Weinstein about her experience navigating her father’s early-onset Alzheimer’s diagnosis, a journey that reshaped her understanding of family, identity, and grief, alongside her professional work in the humanities.

Dr. Cindy Weinstein is the Eli and Edythe Broad Professor of English at the California Institute of Technology and an Atlantic Fellow for Equity in Brain Health. A scholar of nineteenth-century American literature, she has authored several books and brings a literary lens to the experience of loss and meaning-making.

Together, they explore how Alzheimer’s transforms family dynamics, the evolving landscape of grief, and the healing power of storytelling. Dr. Weinstein reflects on her book Finding the Right Words, co-authored with neurologist Dr. Bruce Miller, and discusses writing as a way to process ambiguity and loss. The conversation also examines the role of caregivers and healthcare professionals, the importance of support communities, and the intersection of literature and neurology in helping us understand what it means to live through profound change.

How to Find Cindy Weinstein:

Website: https://www.professorcindy.com/ 

LinkedIn: https://www.linkedin.com/in/cindyaweinstein/ 

Email: [email protected] 

Finding the Right Words https://www.amazon.com/Finding-Right-Words-Story-Literature/dp/1421441268/ref=mp_s_a_1_1?keywords=finding+the+right+words&qid=1672247863&sprefix=finding+the+r&sr=8-1

Email addresses are:

[email protected]

[email protected]

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In this episode of the Resilient Aging Unfiltered podcast, Dr. Dani Cabral interviews Cameron Carter, CEO and co-founder of Rosarium Health. Rosarium is a platform that helps households to age in the community with accessible home modifications and remediation services. 

They discuss the importance of home modifications for aging in place, the misconceptions surrounding costs and accessibility, and the role of occupational therapists in ensuring safety and comfort for older adults. Cameron shares his personal journey and motivation for starting Rosarium, the challenges of navigating the healthcare system, and the innovative technologies that can support aging individuals. The conversation emphasizes the need for proactive planning and community support as we age.

How to Find Cameron Carter:

LinkedIn: https://www.linkedin.com/in/cameron-carter-62117175/ 

Instagram: https://www.instagram.com/rosarium_health/ 

Email: [email protected] 

Website: https://www.rosariumhealth.com/ 

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In this episode of the Resilient Aging Unfiltered podcast, Dr. Dani Cabral speaks with Dr. Traci DeSplinter about midlife women's health, focusing on hormonal changes, sleep quality, and the importance of personalized care. They discuss the critical window of midlife for preventing chronic diseases, including Alzheimer's, and the role of estrogen and sleep in overall health. 

Dr. DeSplinter emphasizes the need for women to advocate for themselves in healthcare and the potential for growth and independence during menopause.

How to Find Dr. Traci DeSplinter

Facebook: https://www.facebook.com/TraciDeSplinterMD

Instagram: https://www.instagram.com/tracidesplintermd/

Website: https://tracidesplintermd.com/ 

=================

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In this episode of the Resilient Aging Unfiltered podcast, Dr. Dani Cabral interviews Dr. Dana Gibbs, a board-certified otolaryngologist and thyroid expert. Dr. Gibbs shares her personal journey with thyroid imbalance and how it transformed her approach to medicine. The conversation delves into the complexities of thyroid health, the impact of menopause on hormonal balance, and the importance of personalized treatment. Dr. Gibbs emphasizes the role of strength training and lifestyle factors in maintaining health as we age, and the significance of finding a knowledgeable healthcare provider for effective treatment.

How to Find Dr. Dana GibbsWebsite: https://danagibbsmd.com/home Podcast: https://www.buzzsprout.com/2373989 Facebook: https://www.facebook.com/ThyroidClarityMD/ Instagram: https://www.instagram.com/danagibbsmd/ Youtube: https://www.youtube.com/@danagibbsmd8190 Thyroid Clarity Check-Up: danagibbsmd.com/checkup

💡Learn More About BrainLove and Join our Email List Discover our innovative approach to Alzheimer’s, brain aging, and resilient care.→ Visit ⁠⁠www.mybrainlove.com⁠⁠ 🧠 Book Your Free BrainLove Discovery CallMeet with us to explore how BrainLove can support you or your loved one. → Schedule now: ⁠⁠https://calendly.com/drcabral-mybrain... 💙 Follow Us on Social MediaBe part of the BrainLove movement.→ Instagram: ⁠⁠@brainlovecommunity⁠⁠→ Facebook: ⁠⁠@brainlovecommunity⁠⁠ 🎙️Want to Suggest a Topic?We’d love to hear from you.