In this episode, we unpack the essentials of drug therapy for respiratory conditions and select anti-infective agents, with a focus on prototypes every nurse should know. We’ll review common respiratory medications—including pseudoephedrine (decongestant), dextromethorphan (antitussive), guaifenesin (expectorant), and acetylcysteine (mucolytic)—exploring their mechanisms, clinical uses, and safety concerns, especially with combination cold remedies and regulated ingredients. In the second half, we turn to anti-infective therapies, covering macrolides, clindamycin, and linezolid, emphasizing their spectrum of activity, key adverse effects like hepatotoxicity and pseudomembranous colitis, and essential nursing considerations for safe administration. By the end, you’ll have a practical framework for understanding these medications, recognizing complications, and prioritizing patient safety in both respiratory and infectious disease care.