This podcast discuss the rapidly advancing field of de-extinction, highlighting the crucial role of artificial intelligence (AI) in making this a tangible scientific pursuit. AI is presented not merely as a tool but as an architect across all stages, from reconstructing degraded ancient DNA and predicting gene function to optimising gene editing and modelling ecological impacts. While companies like Colossal Biosciences pursue ambitious projects for species like the woolly mammoth and dire wolf, often driving technological innovation with commercial spin-offs, organisations like Revive & Restore focus on genetic rescue for endangered species, illustrating differing approaches within this landscape. The podcast underscore the significant technical, ecological, and ethical challenges inherent in de-extinction, particularly concerning animal welfare, resource allocation, and potential ecological disruption, while also pointing to valuable spillover innovations benefiting broader conservation and human health.

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