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Welcome to Part 1 of our Peptide Series, where we break down the science behind today’s most talked-about compounds–starting with retatrutide.

In this episode, we dive into the mechanism of action of retatrutide, the first GLP-1, GIP, and glucagon triple agonist, and why it represents a major shift in obesity pharmacology.

We cover:

• What GLP-1, GIP, and glucagon receptors actually do
• How retatrutide drives satiety, insulin signaling, and energy expenditure simultaneously
• Why adding glucagon changed the game
• A clear breakdown of the clinical trial data so far
• How retatrutide compares to current drugs like semaglutide and tirzepatide

This episode is your mechanism-first foundation for understanding where peptide-based fat loss is headed.

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