Cloud infrastructure offers a new set of building blocks for cost effectively deploying and managing applications. One of the first questions encountered is often which application workloads present the best fit? We’ll start by profiling different environments (datacenter, hosted and public/private cloud) and highlight the application characteristics that align well for each. We’ll then discuss the most common use cases we encounter and the reference architectures we’ve used to deliver them. Along the way, we’ll work to provide guidance how to evaluate company workloads for public, private and hybrid cloud deployments and when it makes sense to re-architect applications.