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Episode 64 Psorasis

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Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025

Outro Music: Ambient Tension by Alex Grohl

Courtesy of Pixabay under Creative Commons non-commercial use.

Produced by: Todd Fredricks DO MSS 

Edited by: Todd Fredricks DO MSS

Answers for Episode 63 AcneQuestion 1

A 17‑year‑old adolescent presents with moderate inflammatory acne on the face and back. Microbiome analysis of her lesions shows decreased alpha diversity and an overrepresentation of Enterococcaceae on both the face and back. Which of the following best explains these findings?

D. Dysbiosis characterized by decreased microbial diversity and overgrowth of specific taxa

Question 2

A 19‑year‑old woman with moderate acne begins treatment with 2% supramolecular salicylic acid (SSA) for 8 weeks. At follow‑up, she reports clinical improvement. Microbiome analysis shows increased alpha and beta diversity and reductions in Staphylococcus, Ralstonia, and Streptococcus species. Which mechanism best explains these findings?

B. Anti‑inflammatory effects with stabilization of microbial communities

Question 3

A researcher evaluates the impact of different acne treatments on the cutaneous microbiome. She notes that only one standard therapy consistently produced a statistically significant change in alpha diversity across multiple studies included in a meta‑analysis. Which treatment is she referring to?

D. Topical benzoyl peroxide (BPO)

Paper for Next Week:

Wollenberg, A., M. Kinberger, B. Arents, N. Aszodi, S. Barbarot, T. Bieber, H. A. Brough, et al. 2025. “European Guideline (EuroGuiDerm) on Atopic Eczema: Living Update.” Journal of the European Academy of Dermatology and Venereology 39: 1537–1566. https://doi.org/10.1111/jdv.20639.

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