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Episode 65 Atopic Dermatitis

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Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025

Outro Music: Christmas by Alex Grohl

Courtesy of Pixabay under Creative Commons non-commercial use.

 Produced by: Todd Fredricks DO MSS 

Edited by: Todd Fredricks DO MSS

 Answers for Episode 64 Psoriasis

 Question 1 — Psoriasis Comorbidities and Early Detection

A 36‑year‑old man with a 10‑year history of chronic plaque psoriasis presents for evaluation. He reports new-onset morning stiffness in his lower back lasting more than an hour and improving with activity. His exam shows limited lumbar flexion but no peripheral joint swelling. Radiographs of the sacroiliac joints are unremarkable. Which of the following is the most important reason to screen this patient promptly for psoriatic arthritis?

D. Early diagnosis reduces the risk of irreversible joint damage

Question 2 — Systemic Therapy Safety Considerations

A 29‑year‑old woman with erythrodermic psoriasis is prescribed a systemic retinoid. After one month of treatment, she reports dry lips, hair thinning, and peeling skin. She asks when she can safely become pregnant after stopping therapy. Laboratory studies show mild hyperlipidemia. Which medication is she most likely taking?

C. Acitretin

Question 3 — Treatment Escalation and Contraindications

A 45‑year‑old woman with moderate to severe plaque psoriasis has failed topical therapy and methotrexate. She is being evaluated for biologic therapy. Her past medical history is significant for Crohn’s disease. Which biologic agent should be avoided in this patient?

B. Secukinumab

Paper for Next Week:

 Anders Boutrup Funch, Carsten Geisler, and Charlotte Menné Bonefeld.
“Allergic Contact Dermatitis: Immunopathology and Potential Therapeutic Strategies.”
Journal of Clinical Medicine 14, no. 20 (2025): 7175. https://doi.org/10.3390/jcm14207175.

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