Rupert Sheldrake is one of the most thoughtful, lucid people I have ever met. In this conversation we talk about the foundations of science, both as an institution and as a path to knowledge. Like all the institutions of modernity, science faces a crisis that is increasingly recognized within science itself. Part of it is the "replicability crisis," but as Rupert and I discuss, that is but a gateway into deeper epistemological and metaphysical problems.