Drs Stanley Cohen and Caylib Durand discuss the treatment paradigm for psoriatic arthritis and the role of methotrexate and other conventional synthetic disease-modifying antirheumatic drugs.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/970783). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Psoriatic Arthritis https://emedicine.medscape.com/article/2196539-overview

Psoriatic Arthritis: Expert Review and Commentary From Published Literature https://themedicalxchange.com/en/2021/11/23/3021-new-grappa-treatment-recommendations-for-psoriatic-arthritis/

GRAPPA Treatment Recommendations: 2021 Update https://www.jrheum.org/content/early/2022/03/10/jrheum.211331

What Is GRADE? https://bestpractice.bmj.com/info/us/toolkit/learn-ebm/what-is-grade/

Rheumatoid Arthritis (RA) Workup https://emedicine.medscape.com/article/331715-workup#c6

leflunomide (Rx) https://reference.medscape.com/drug/arava-leflunomide-343203

sulfasalazine (Rx) https://reference.medscape.com/drug/azulfidine-sulfasalazine-343280

AB0533 Combination of Methotrexate and Leflunomide Is Safe and Has Good Drug Retention Among Patients With Psoriatic Arthritis https://ard.bmj.com/content/80/Suppl_1/1298.1

apremilast (Rx) https://reference.medscape.com/drug/otezla-apremilast-999915

Etanercept and Methotrexate as Monotherapy or in Combination for Psoriatic Arthritis: Primary Results From a Randomized, Controlled Phase III Trial https://onlinelibrary.wiley.com/doi/10.1002/art.40851

Psoriatic Arthritis Treatment & Management https://emedicine.medscape.com/article/2196539-treatment

Iritis and Uveitis https://emedicine.medscape.com/article/798323-overview

Paradoxical Gastrointestinal Effects of Interleukin-17 Blockers https://ard.bmj.com/content/79/9/1132