Delve into the realm of implementation science and its significance in bridging the gap between research-based evidence and critical care practice. Host Marilyn N. Bulloch, PharmD, BCPS, FCCM, is joined by Anne E. Sales, PhD, RN, to discuss the complexity of implementation science, which involves understanding human behavior change within organizational constraints. They explore examples such as hypertension treatment to illustrate the challenges and opportunities of implementing evidence-based practices. They discuss the importance of context, resources, and stakeholder engagement in successful implementation efforts in the critical care setting where complex interventions and rapid changes are common. Dr. Sales is a nurse and professor at the Sinclair School of Nursing and the Department of Family and Community Medicine in the School of Medicine at the University of Missouri, and associate dean for implementation research and health delivery effectiveness in the School of Medicine. She is a research scientist at the Center for Clinical Management Research at the VA Ann Arbor Health System in Ann Arbor, Michigan, USA.