Science Signaling's Chief Scientific Editor gives an overview of mTOR signaling.

The sets of kinases required by different cancer cell lines are highly divergent.

The activity of a bacterial FHA domain-containing protein is regulated intramolecularly.

Autophosphorylation events that control the activity of the FGF receptor are kinetically controlled and disrupted by a mutation associated with glioblastoma.

The guanine nucleotide exchange factor Brx is required in lymphocytes for the expression of nfat5 in response to osmotic stress.

Inactivating mTOR signaling in the adult mouse prostate decreases the incidence of cancer.

Leptin secreted by adipose tissue decreases insulin production through both direct and indirect mechanisms.

The scaffold protein mAKAP localizes factors important for the cellular response to hypoxia.

Binding of CD3ε subunits to plasma membrane lipids blocks T cell receptor signaling.

Sam Lee and Pat Ongusaha discuss their research on the mechanisms by which ultraviolet B radiation induces cell death.