New state-of-the-art chronologic measurements of rocks brought to Earth by Apollo astronauts reveal that many of the historical age determinations are erroneous. The new measurements presented by cosmochemist Lars Borg demonstrate that the Moon's mantle and crust formed contemporaneously between 4.33 and 4.38 billion years ago. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 35696]

Limited medical equipment on space craft makes medical care in space a real challenge. Ordinary problems must be dealt with, as well as problems related to the unique environment of space. As NASA plans for new crewed exploration missions, beyond low earth orbit, telemedicine support will be limited, and medical evacuation to earth will no longer be possible. To address this problem, LLNL and NASA Ames Research Center are developing a novel diagnostic instrument to help provide medical care on deep space missions. The technology consists of a blood analysis system, based on microfluidics, together with a breath analysis system that uses carbon nanotube sensors. The technology is designed to support future missions to the moon and Mars, and it is expected to be used for terrestrial medicine as well, in a variety of arenas where medical resources are limited. Series: "Lawrence Livermore National Lab Science on Saturday" [Health and Medicine] [Science] [Show ID: 35697]

Our planet has been continually bombarded by asteroids since its formation, 4.5 billion years ago. While the frequency of large impacts has decreased, many potential Near-Earth Object threats remain undiscovered, so if or when they will impact Earth remains unknown. Fortunately, if an Earth-threatening asteroid is discovered in time, there are ways to mitigate or even prevent a disaster. Scientists at LLNL provide computer simulations in preparation these scenarios so if the time comes where an asteroid is headed our way, we will be prepared. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 35698]

The blood-brain-barrier (BBB) is a special structure in the body that helps to protect the brain from unwanted toxins and germs. Unfortunately, this barrier can also make it extremely difficult for therapeutics to reach their intended target within brain. Lawrence Livermore Lab scientists describe how combining experimental techniques with computational methods, making use of some of the fastest supercomputers in the world, can speed up the process of optimizing therapeutics to cross the BBB. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34467]

Cancer becomes highly dangerous when it spreads from its original site to a different vital organ. These secondary tumors called metastases are what kill most patients. Despite hundreds of years of research, it is not understood why, where, and how cancer spreads to organs like the brain. Lawrence Livermore Lab scientist describes how they bring together cancer biology, 3D printing and material science, to understand and hopefully prevent metastases in the future. Series: "Lawrence Livermore National Lab Science on Saturday" [Health and Medicine] [Science] [Show ID: 34466]

The human brain contains approximately 86 billion neurons, and 100 trillion connections between those neurons. Despite our inability to image each neuron and determine their exact connective patterns, several approaches for noninvasive imaging of the living brain have been developed and utilized to great benefit. LLNL scientist Alan Kaplan explores the immense landscape of the human brain and quantifies the brain in terms of data flow. Then describes engineering applications of recorded electrophysiological data and explores methods for analyzing such data to determine the pattern of signals that arise during various activities and mood states. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34465]

The human brain is composed of billions of cells that communicate through chemical and electrical signals. LLNL microelectrodes can interface directly with the brain to allow us to monitor and manipulate the dynamics of these brain signals. LLNL microelectrodes are flexible and microfabricated in dense arrays that allow them to collect large amounts of information over long periods of time in the body. Scientists Anna Belle and Allison Yorita go over how these arrays are microfabricated and their diagnostic and therapeutic applications. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 34464]

Proteins are nature’s machines, performing tasks from transforming sunlight into useable energy to binding oxygen for transport through the body. These functions depend on structural arrangement of atoms within the protein, which was, until recently, only possible to measure statistically, in easily crystallized samples via conventional X-ray diffraction. In the past decade, X-ray Free Electron Lasers (XFELs), a new type of X-ray source, have begun to come online. Using ultra-bright, ultrafast X-ray pulses of the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory, this technology allows us to measure not only static pictures of protein structure but to record “molecular movies” of proteins in action. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33432]

Accelerator mass spectrometry (AMS) is a sensitive mass spectrometric method for detecting and quantifying rare long-lived isotopes with high precision. This technique is widely employed in the earth and environmental sciences and is now being applied in the biomedical fields. AMS is primarily used to in the areas of pharmacology and toxicology to investigate the absorption, distribution, metabolism, and excretion of radiolabeled drugs, chemicals, and nutrients, as well as in the detection of chemically modified DNA and proteins in animal models and humans. The exquisite sensitivity (10-18 mol) of AMS allows for the use of low chemical and radioisotope doses and relatively small sample sizes, which enables studies to be performed safely in humans, using exposures that are environmentally or therapeutically relevant. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33431]

How often do you wonder about supercomputers and computers that "think" like humans? Supercomputers have been used to model complex scientific phenomena for decades. Now, scientists are entering a new era in computing, and computers are learning in a way that is similar to the human brain. With enough information, computers can learn to solve problems in novel and interesting ways. Specialized computers can even solve these problems using significantly less energy than "classical" computers. This talk describes using supercomputers to solve challenging problems and the evolving technologies of learning systems. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 33430]