QUEST explores how the San Francisco Botanical Garden is toiling to bring one of the city's rarest native plants, the Franciscana manzanita, back from the brink of extinction.

Forest ecologist Steve Sillett is leading a team of scientists as they climb and measure every branch of some of the last and tallest old growth redwoods in California. Their goal is to learn how these ancient giants have historically responded to climatic shifts and to monitor how they are being impacted today by global warming.

Ocean tides rise and fall twice a day, influenced by the gravitational forces of the sun and moon. Studying tides' rhythmic movements helps us understand both the ocean and the cosmos. Astronomer Ben Burress explains how tides work, and QUEST visits Crissy Field in San Francisco to see the oldest continually operating tidal gauge in the Western Hemisphere.

The California Academy of Sciences has the largest collection of biological reference materials west of the Mississippi. Dating back over 100 years, the collection provides a treasure trove of biological information for scientists and researchers studying the natural world. Norman Penny, the Collections Manager of the Entomology Department, gives QUEST a small peek at The Academy’s vast butterfly collection.

Can fire save the endangered Mission Blue Butterfly? The Golden Gate National Recreation Area experiments with using controlled burns to improve habitat for this critically imperiled Bay Area native.

The Farallon Islands off the coast of San Francisco are a vital home to many birds and marine mammals. While the forbidding and inhospitable nature of the Farallones may be ideal for wildlife, it also makes this a difficult place for scientists to live and work. QUEST ventures out to these jagged rocks to get a glimpse of daily life on the islands and what it’s like there for the researchers from PRBO Conservation Science.

California Highway One, between Pacifica and Montara, was carved out of the steep coastal cliffs. Plagued by closures due to rockslides and land slippage, this route has earned the nickname "The Devil's Slide." Now two tunnels beneath San Pedro Mountain, each 30-feet wide and 4,200-feet long are being dug to bypass it. QUEST meets the engineers and geologists deep underground to learn how Caltrans is digging this new tunnel.

Artist Kate Nichols longed to paint with the iridescent colors of butterfly wings, but no such pigments existed. So she became the first artist-in-residence at Lawrence Berkeley National Laboratory to synthesize nanoparticles and incorporate them into her artwork.

Meet Shelley, a car that drives itself. Researchers at Stanford University have developed an autonomous race car and plan on taking it on one of the toughest courses in the country. First, the car is taking them for a test ride at the Santa Clara County Fairgrounds.

Pale ghosts that hide amidst their gigantic siblings, only a few dozen Albino redwood trees are known to exist. They are genetic mutants that lack the chlorophyll needed for photosynthesis-- how and why they survive is a scientific mystery. QUEST ventures into the deep canopy of Henry Cowell Redwoods State Park near Felton, California to track down these elusive phantoms of the forest.