Science Research Weekly

Science Research Weekly

By Mark R WilliamsonScience
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Science Research Weekly episodes

  • Episode 34: Ribozyme Samurai

    Get ready for distractingly dense planets, SAMURI ribozymes, serious clinical sepsis incidence, jittering in R, the Bioconductor 3.18 release schedule, and the NIH HEAL Initiative. Science On.


    References:

    • A super-massive Neptune-sized planet
    • A SAM analogue-utilizing ribozyme for site-specific RNA alkylation in living cells
    • The Rhabdodontidae (Dinosauria, Ornithischia), an enigmatic dinosaur group endemic to the Late Cretaceous European Archipelago
    • Estimating Sepsis Incidence Using Administrative Data and Clinical Medical Record Review
    • Model data from published summary statistics
    • Grants For R Language Infrastructure Projects Available Now!
    • When to use Jitter
    • Insights on R Package Quality and Validation for Clinical Trials
    • Bioconductor 3.18 Release Schedule
    • NOSI: Quantum Sensing in Biomedical Applications
    • NOSI: Research Supplements to Promote Re-Entry, Re-integration into, and Re-training in Health-Related Research Careers
    • NIH: HEAL Initiative
    • NSF: Postdoctoral Research Fellowships in Biology

    • R Packages:

      • karyotapR: DNA Copy Number Analysis for Genome-Wide Tapestri Panels
      • phantSEM: Create Phantom Variables in Structural Equation Models for Sensitivity Analyses
      • juicedown: 'juice' + 'markdown': Convert 'R Markdown' into 'HTML' with Inline Styles
      • procs: Recreates Some 'SAS®' Procedures in 'R'
      • webmap: Create Interactive Web Maps Using 'The National Map' Services
      • 7 min
      • Episode 33: Microbe-Skewering Micro-Spikes

        Get ready for allergic disease and the infant gut microbiome, three-eyed arthropods, titanium micro-spikes for killing pathogenic fungus, array thinking in R, and a grant to culture difficult eukaryotic pathogens. Science On.


        References:

        • Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease
        • The early Cambrian Kylinxia zhangi and evolution of the arthropod head
        • Apoptosis of Multi-Drug Resistant Candida Species on Microstructured Titanium Surfaces
        • Exploring Relationships with Correlation Heatmaps in R
        • Plotting Multiple Lines on a Graph in R: A Step-by-Step Guide
        • 6 New books added to Big Book of R
        • NIH: Research Tools for Difficult to Culture Eukaryotic Pathogens
        • NIH: Early-stage Biomedical Data Repositories and Knowledgebases
        • Gateway for Cancer Research: Integrative Program

        • R Packages:

          • condensr: Academic Group Website Generator
          • ruminate: A Pharmacometrics Data Transformation and Analysis Tool
          • phylosem: Phylogenetic Structural Equation Model
          • 6 min
          • Episode 32: The Kirigami Engineers

            Get ready for naked-mole rat longevity transfer into mice, kirigami for engineering, a new antibiotic from microbial dark matter, eDNA for vertebrate biomonitoring, Julia cracking the top 20 programming languages, template files with R, and a Predoctoral to Postdoctoral Fellow Transition Award. Science On.


            References:

            • Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
            • MIT engineers use kirigami to make ultrastrong, lightweight structures
            • An antibiotic from an uncultured bacterium binds to an immutable target
            • Vertebrate environmental DNA from leaf swabs
            • JuliaHub Newsletter August 2023
            • Bootstrap predicted means by using PROC GLMSELECT
            • Creating template files with R
            • Best Practices for Data Cleaning and Preprocessing
            • NIH: Predoctoral to Postdoctoral Fellow Transition Award
            • NIH: Research Projects to Enhance Applicability of Mammalian Models for Translational Research
            • NSF: Ecology and Evolution of Infectious Diseases

            • R Packages:

              • artpack: Creates Generative Art Data
              • syllogi: Collection of Data Sets for Teaching Purposes
              • rmass2: Repeated Measures with Attrition: Sample Sizes and Power Levels for 2 Groups
              • scriptloc: Get the Location of the R Script that is Being Sourced/Executed
              • 8 min
              • Episode 31: Are You Not Entertained?

                Get ready the Dinosaur Coliseum, cancer-detecting bioengineer bacteria, embedding Unicode into SAS, a web-crawling Katana, and a Million Dollar Bike ride for rare disease research. Science On.


                References:

                • Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
                • Vertebrate ichnology and palaeoenvironmental associations of Alaska’s largest known dinosaur tracksite in the Cretaceous Cantwell Formation (Maastrichtian) of Denali National Park and Preserve
                • Engineered bacteria detect tumor DNA
                • Sustained wet–dry cycling on early Mars
                • Add Unicode symbols and format text labels in SAS
                • Plot confidence intervals for a regression model in SAS
                • Bootstrap confidence intervals for the predicted mean in a regression model
                • Mastering Data Visualization: A Guide to Harnessing the Power of R’s par() Function
                • GitHub: katana
                • NIH/NIA: R43/R44 REDI Award
                • NIH/NIA: R41/R42 REDI Award
                • NSF: Physics Investigator-Initiated Research Projects
                • NSF: Smart Health and Biomedical Research in the Era of Artificial Intelligence and Advanced Data Science
                • Air Force: Science and Technology Fellowship
                • Marfan Foundation: Innovators Grants
                • Million Dollar Bike Ride Pilot Grant Program
                • AAI Intersect Fellowship Program
                • AHA: AIREA
                • McKnight: Scholar Award

                • R-packages:

                  • graposas: Graphical Approach Optimal Sample Size
                  • osmclass: Classify Open Street Map Features
                  • bulkreadr: The Ultimate Tool for Reading Data in Bulk
                  • handcodeR: Text Annotation App
                  • unicol: The Colors of your University
                  • 8 min
                  • Episode 30: A Bit of a (DNA) Stretch

                    Get ready for bacterial circadian clocks, a new form of bacterial transduction, the effect of DNA stretches and twists on mutation rates, web development training materials, and a music-based intervention grant. Science On.


                    References:

                    • The circadian clock of the bacterium B. subtilis evokes properties of complex, multicellular circadian systems
                    • Dual pathogenicity island transfer by piggybacking lateral transduction
                    • Structural underpinnings of mutation rate variations in the human genome
                    • Enhance Your Plots with the text() Function in R
                    • GitHub: Web-Dev-For-Beginners
                    • NIH: Music-based Interventions Toolkit for Brain Disorders of Aging
                    • NSF: Artic Research Opportunities
                    • AHA: Institutional Research Enhancement Award

                    • R Packages:

                      • none
                      • 6 min
                      • Episode 29: Greengenes 2, This Time, It’s Personal

                        Get ready for ancient, icy nematodes, renewable plastics, Greengenes volume 2, linear model transformations in R, and Gut-Brain Communication in Parkinson’s grants. Science On.


                        References:

                        • A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva
                        • Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort
                        • Biorenewable and circular polydiketoenamine plastics
                        • Greengenes2 unifies microbial data in a single reference tree
                        • SatRdays London 2023 – Recordings
                        • One Weird Trick to Make Ggplot2 Columns the Same Width
                        • Linear model and Transformations
                        • GitHub: ClickHouse
                        • NIH: Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01)
                        • NIH: Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21)
                        • NIH: A Consortium for Gut-Brain Communication in Parkinson’s Disease (U01)
                        • NIH: A Consortium for Gut-Brain Communication in Parkinson’s Disease (U24)
                        • McKnight Foundation: Neurobiology of Brain Disorders Award
                        • ASCO: Young Investigator Award

                        • R Packages:

                          • none
                          • 6 min
                          • Episode 28: Fungal Enlightenment

                            Get ready for fungal genome mining, new R books, and a cancer nanotechnology grant. Science On.


                            References:

                            • Size Dependence of the Bouncing Barrier in Protoplanetary Dust Growth
                            • Near-Infrared Fluorescent Biosensors Based on Covalent DNA Anchors
                            • Mining for a new class of fungal natural products: the evolution, diversity, and distribution of isocyanide synthase biosynthetic gene clusters
                            • what is a randomized complete block design?
                            • Simplify Your Code with R’s Powerful Functions: with() and within()
                            • 7 New books added to Big Book of R
                            • GitHub: Cal.com
                            • NOSI: Lymphatic System in Health and Disease
                            • NCI: Innovative Research in Cancer Nanotechnology

                            • R Packages:

                              • MultiClassROC: ROC Curves for Multi-Class Analysis
                              • UpDown: Detecting Group Disturbances from Longitudinal Observations
                              • 4 min
                              • Episode 27: Dog Bites Dinosaur

                                Get ready for DNA origami, an Elvis-impersonator pterodactyl, self-healing metal, a dinosaur-chomping mammal, the case of the missing dark matter, a lazier way to use Docker, and a grant for theoretical physics hubs. Science On.


                                References:

                                • DNA-origami-directed virus capsid polymorphism
                                • Petrodactyle wellnhoferi gen. et sp. nov.: A new and large ctenochasmatid pterosaur from the Late Jurassic of Germany
                                • Autonomous healing of fatigue cracks via cold welding
                                • An extraordinary fossil captures the struggle for existence during the Mesozoic
                                • The massive relic galaxy NGC 1277 is dark matter deficient
                                • Dates and location for useR! 2024
                                • JuliaHub Newsletter July 2023
                                • Standardize regression coefficients for models that include categorical variables
                                • GitHub: lazydocker
                                • GitHub: how-web-works
                                • NSF: Focused Research Hubs in Theoretical Physics

                                • R Packages:

                                  • badgen: Fast and Simple Badge Generator
                                  • forestly: Interactive Forest Plot
                                  • quickcode: A Compilation of Some Frequently Used R Functions
                                  • 7 min
                                  • Episode 26: Living Cameras and Old Universes

                                    Get ready for weird whales, bacterial sample collection via lollipop, hints at life on Mars, living digital cameras, a much older universe, free training on 67 programming languages, and a Housing and Urban Development grant for radon detection and mitigation. Science On.


                                    References:

                                    • Convergent evolution of skim feeding in baleen whales
                                    • At-Home Saliva Sampling in Healthy Adults Using CandyCollect, a Lollipop-Inspired Device
                                    • Microeukaryotic predators shape the wastewater microbiome
                                    • The effects of board games on math skills in children attending prekindergarten and kindergarten: A systematic review
                                    • Oncogene-like addiction to aneuploidy in human cancers
                                    • A mid-Cambrian tunicate and the deep origin of the ascidiacean body plan
                                    • Diverse organic-mineral associations in Jezero crater, Mars
                                    • A biological camera that captures and stores images directly into DNA
                                    • JWST early Universe observations and ΛCDM cosmology
                                    • datasetR – R package for creating datasets
                                    • Unveiling a New Era in Molecular Visualization: Introducing shiny.molstar for Large Molecular Structures Visualization in R
                                    • Array Languages: R vs APL
                                    • exercism
                                    • HUD: Radon Testing and Mitigation Demonstration for Public Housing
                                    • DOD: Toxic Exposures

                                    • R Packages:

                                      • grpnet: Group Elastic Net Regularized GLM
                                      • bbmix: Bayesian Model for Genotyping using RNA-Seq
                                      • TOmicsVis: Transcriptome Visualization Process Scheme
                                      • 10 min
                                      • Episode 25: Top Transposon, Maverick

                                        Get ready for metallic 3D prints, Cambrian predators that skipped appendage-day at the gym, the mechanisms of chemical gardens, the mysteries of virus-like transposon ‘Mavericks’, coding cheat sheets, and a rare disease grant. Science On.


                                        References:

                                        • Remote detection of a lunar granitic batholith at Compton–Belkovich
                                        • Metallic gels for conductive 3D and 4D printing
                                        • Raptorial appendages of the Cambrian apex predator Anomalocaris canadensis are built for soft prey and speed
                                        • Pattern selection by material aging: Modeling chemical gardens in two and three dimensions
                                        • Virus-like transposons cross the species barrier and drive the evolution of genetic incompatibilities
                                        • An Easy Way to Customize Your Shiny App Theme
                                        • CheatSheet for coding in R, Python and Julia
                                        • GitHub: Tkinter-Designer
                                        • NIH: Preclinical Proof of Concept Studies for Rare Diseases
                                        • NIH: Cellular and Molecular Biology of Complex Brain Disorders (R01)
                                        • NIH: Cellular and Molecular Biology of Complex Brain Disorders (R21)
                                        • Jonathan F. Reichert Foundation: ALPhA Immersions Support
                                        • AABB Foundation: Early-Career Scientific Research Grants Program
                                        • R Packages:

                                          • esem: Exploratory Structural Equation Modeling ESEM
                                          • protHMM: Protein Feature Extraction from Profile Hidden Markov Models
                                          • ZooID: Load, Segment and Classify Zooplankton Images
                                          • 8 min

                                          About Science Research Weekly

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                                          A weekly overview of helpful scientific research topics and the successor of the podcast Statistics Weekly. Every week, I will cover 3 topic areas: Research Articles, Research Tools, and Research…