In this episode, we are joined by Dr. Xing to delve into the innovative use of machine learning in predicting the embryonic aneuploidy risk in female IVF patients. Infertility affects approximately 12% of women of reproductive age in the United States, with aneuploidy in eggs significantly contributing to early miscarriages and IVF failures.

Dr. Xing discusses his team's work in using whole-exome sequencing data to evaluate machine learning-based classifiers for predicting aneuploidy risk. Their efforts have achieved encouraging results with the area under the receiver operating curve of 0.77 and 0.68, respectively, across two exome datasets.

This discussion also sheds light on the potential aneuploidy risk genes identified, such as MCM5, FGGY, and DDX60L. These genes and their molecular interaction partners are enriched in meiotic-related gene ontology categories and pathways, like the microtubule organizing center and DNA recombination.

By demonstrating that sequencing data can help predict a patient's aneuploidy risk, Dr. Xing's work opens up new avenues for enhancing clinical diagnosis and provides promising targets for future aneuploidy studies.

Keywords: Dr. Xing, Machine Learning, Embryonic Aneuploidy Risk, Infertility, IVF, Whole-exome Sequencing Data, Receiver Operating Curve, MCM5, FGGY, DDX60L, Meiotic-related Gene Ontology Categories, DNA Recombination, Clinical Diagnosis.

Predicting embryonic aneuploidy rate in IVF patients using whole-exome sequencing https://doi.org/10.1007/s00439-022-02450-z

In this episode, we're delighted to welcome Dr. Purkis as he shares his research on deep-sea brine pools, unique environments that house extremophile microbes, and immaculately preserved sedimentary sequences. His team has located a complex of brine pools in the Gulf of Aqaba, consisting of one major pool of 10,000 m2 and three smaller pools.

Join us as Dr. Purkis takes us through their exploration process, which involves bathymetric and geophysical observations, sediment coring, and direct brine sampling. They discovered that the main pool conserves a sedimentary stratigraphy extending over at least 1200 years. This timeline captures turbidites, which are likely products of flash floods and local seismic activity, along with tsunamigenic terrestrial sediment.

Termed the NEOM Brine Pools, these bodies of water broaden the known geographical distribution of Red Sea brine pools. They also present an exceptional environment for conserving the sedimentary markers of regional climatic and tectonic occurrences. Delve into the fascinating world of deep-sea brine pools and their significance in our understanding of historical climate and tectonic events.

Keywords: Dr. Purkis, Deep-sea Brine Pools, Extremophile Microbes, Sedimentary Sequences, Gulf of Aqaba, Turbidites, Tsunamigenic Terrestrial Sediment, NEOM Brine Pools, Red Sea, Climatic Events, Tectonic Events.

Purkis, S.J., Shernisky, H., Swart, P.K. et al. Discovery of the deep-sea NEOM Brine Pools in the Gulf of Aqaba, Red Sea. Commun Earth Environ 3, 146 (2022). https://doi.org/10.1038/s43247-022-00482-x

In this episode, we are thrilled to host the renowned physicist, Dr. Kotwal, to explore the implications of the new and precise measurement of the W boson mass. The W boson, a mediator of the weak force between elementary particles, has its mass heavily constrained by the symmetries of the Standard Model (SM) of particle physics. Therefore, measuring the mass of the W boson poses a stringent test of the SM.

Dr. Kotwal discusses the Collider Detector at Fermilab (CDF) Collaboration's recent findings, which unexpectedly revealed that the mass of the W boson was significantly higher than the SM predicts. This discrepancy, measured at an impressive 7 standard deviations, is drawn from data collected in proton-antiproton collisions at the Tevatron particle accelerator.

Delving into the implications of this finding, Dr. Kotwal helps listeners understand the consequences of this significant tension with the SM expectation. He takes us through the exciting journey of how a sample of approximately 4 million W boson candidates was used to obtain the most precise measurement of the W boson mass to date.

Join us as we explore what this means for the future of particle physics and our understanding of the universe.

Keywords: Dr. Kotwal, W Boson, Collider Detector at Fermilab, Tevatron particle accelerator, Standard Model, Proton-Antiproton Collisions, Particle Physics.

W bosons mediate the weak interaction, one of the fundamental forces in physics. https://doi.org/10.1126/science.abk1781 High-precision measurement of the W boson mass with the CDF II detector

Unraveling the intricacies of microbiomes and their dynamics is a central challenge in harnessing their potential benefits. Dr. Hero joins us in this episode to discuss the application of a Long Short-Term Memory (LSTM) framework to predict community assembly and metabolite production in a synthetic human gut community.

Standard differential equation-based models have been unsuccessful in capturing complex microbial behaviors that don't conform to preset ecological theories. These models also fall short when dealing with increasing community complexity and multiple functions. Dr. Hero and his team are paving a new way with LSTM, a primary tool in deep learning that learns a high-dimensional, data-driven, non-linear dynamical system model. This model is then used to design communities with specific metabolite profiles.

Dr. Hero will share insights on how the LSTM model outperforms the widely utilized generalized Lotka-Volterra model and how the 'black-box' nature of the model can be deciphered to understand microbe-microbe and microbe-metabolite interactions. These findings point to the crucial role of Actinobacteria, Firmicutes, and Proteobacteria in metabolite production, while Bacteroides shape community dynamics.

In this episode, we will delve into how the LSTM model can navigate a vast multidimensional functional landscape to identify communities with unique, health-relevant metabolite profiles and temporal behaviors. Join us as we discuss how LSTM models can guide the design of synthetic microbiomes with targeted, dynamic functions and aid experimental planning.

Keywords: Dr. Hero, LSTM, Microbiomes, Community Assembly, Metabolite Production, Synthetic Human Gut Community, Deep Learning, Microbial Interactions, Actinobacteria, Firmicutes, Proteobacteria, Bacteroides, Generalized Lotka-Volterra Model, Synthetic Microbiomes, Experimental Planning.

Deep Learning Enables Design of Multifunctional Synthetic Human Gut Microbiome Dynamics Alfred O. Hero, et al. doi: https://doi.org/10.1101/2021.09.27.461983

In this enlightening episode, we welcome Dr. Piscicchia to scrutinize the Orch OR (Orchestrated Objective Reduction) consciousness theory in light of the latest experimental results derived from the search for spontaneous radiation. This radiation is predicted by the simplest version of gravity-related dynamical collapse models, and its search has potential implications for our understanding of consciousness and the universe itself.

Dr. Piscicchia provides a critical perspective on the Orch OR theory, highlighting the instances where the theory, when based on the simplest version of gravity-related dynamical collapse, is highly implausible. He shares the comprehensive analysis that led to these conclusions and elaborates on the broad implications of these findings.

Moreover, Dr. Piscicchia discusses the limitations of the current models and elaborates on the future plans towards the development of more realistic gravity-related collapse models. This conversation is not just a deep dive into the intricate intersections of quantum physics and consciousness theories, but also a journey towards understanding the potential future directions of this fascinating research area.

Keywords: Dr. Piscicchia, Orch OR Consciousness Theory, Gravity-Related Dynamical Collapse Models, Quantum Physics, Consciousness, Spontaneous Radiation.

“At the crossroad of the search for spontaneous radiation and the Orch OR consciousness theory”, a critical analysis of the Orch OR consciousness theory https://doi.org/10.1016/j.plrev.2022.05.004

In this episode, Dr. Gu delves into the world of microcargoes and how their transport is integral for both living organisms and various applications in microrobotics, nanotechnology, and biomedicine. Current delivery technologies often face challenges in terms of speed, navigation control, and dispersal by cardiovascular flows. But, as Dr. Gu explains, these problems are largely addressed by cytoskeletal motors in cell biology that carry vesicles along microtubule highways.

Inspired by this biological mechanism, Dr. Gu presents his team's groundbreaking development of artificial microtubules (AMTs), which are structured microfibers embedded with micromagnets. These micromagnets serve as stepping stones to guide particles quickly through flow networks.

Dr. Gu details how this new method facilitates microcargo travel at speeds an order of magnitude faster than existing techniques using the same driving frequency. Additionally, he shares the fascinating discovery of how strong dynamic anchoring effects significantly reduce dispersal, even against potent fluid flows.

Towards the end, we learn about the potential for AMTs to enable the self-assembly of microparticles into active-matter clusters. This assembly further enhances walking speed by collectively bridging over stepping stones, indicating a unique and robust strategy for delivery within microvascular networks and minimally invasive interventions.

Keywords: Dr. Gu, Microcargo, Microrobotics, Nanotechnology, Biomedicine, Artificial Microtubules, Microvascular Networks.

Gu, H., Hanedan, E., Boehler, Q. et al. Artificial microtubules for rapid and collective transport of magnetic microcargoes. Nat Mach Intell (2022). https://doi.org/10.1038/s42256-022-00510-7

Understanding the movements and migrations of ancient humans can often be an intricate puzzle. In this episode, we explore this fascinating topic with Dr. Yue-Chen Liu, who has delved into the peopling of the Micronesian islands. By examining 164 ancient human remains from five different archaeological sites in Remote Oceania, along with 112 present-day individuals from the same area, Liu and his team have unraveled the intricate threads of human migration.

Dr. Liu explains how their analysis unveiled five migratory streams into Micronesia, with three being East Asian-related, one Polynesian, and a fifth from a Papuan source related to mainland New Guineans. Interestingly, this Papuan source, derived from male migrants around 2000-2500 years ago, was distinct from the New Britain–related Papuan source for southwest Pacific populations.

Discussing the people of the Mariana Archipelago, Dr. Liu makes an intriguing observation - they may derive all their precolonial ancestry from East Asian sources, rendering them the only Remote Oceanians without Papuan ancestry.

Dr. Liu also shares how mitochondrial DNA studies revealed a highly differentiated yet localized pattern among early Remote Oceanian communities, implying matrilocal practices. The genetic data indicate that women almost never raised their children in communities different from the ones in which they grew up.

This episode offers a fascinating journey into the ancient human migrations into Micronesia, revealing the interplay of genetics, archaeology, and the human story.

Keywords: Dr. Yue-Chen Liu, Human migrations, Micronesia, Genetics, Archaeology, Ancient DNA, Papuan Ancestry, Matrilocal Practices, Mariana Archipelago.

Ancient DNA reveals five streams of migration into Micronesia and matrilocality in early Pacific seafarers https://doi.org/10.1126/science.abm6536

We often imagine bacteria as microscopic isolated cells or colonies. But what if some defy this common perception? Dr. Gros and Dr. Volland join us on this episode to discuss their discovery of an unusually large, sulfur-oxidizing bacterium with a complex membrane organization and predicted life cycle.

Located in a mangrove swamp, the bacterium, named Candidatus Thiomargarita magnifica, astounded the researchers. While most bacterial species have cells around 2 micrometers in length, this extraordinary bacterium has an average cell length exceeding 9000 micrometers, making it visible to the naked eye!

Through the application of various microscopy techniques and genome sequencing, Dr. Gros and Dr. Volland observed highly polyploid cells with DNA and ribosomes compartmentalized within membranes. They also discovered a fascinating dimorphic life cycle where chromosomes are asymmetrically segregated into daughter cells.

These groundbreaking findings challenge traditional concepts of bacterial cells. The scientists reveal how these characteristics, along with the compartmentalization of genomic material and ribosomes in translationally active organelles, indicate a gain of complexity in the Thiomargarita lineage.

Don't miss this intriguing episode exploring the boundaries of what we know about bacterial cells and their potential complexity.

Keywords: Dr. Gros, Dr. Volland, Candidatus Thiomargarita magnifica, Megabacterium, Polyploid cells, Bacterial cell complexity, Genome sequencing, Asymmetric segregation, Microscopy.

A centimeter-long bacterium with DNA contained in metabolically active, membrane-bound organelles https://doi.org/10.1126/science.abb3634

The phenomenon of migration is not only about physical movement from one location to another; it also involves the journey of the mind. In this enlightening episode, Dr. Ezenwa Olumba takes us through the concept of cognitive migration, sharing his personal experiences as an individual living abroad in the UK but feeling cognitively attached to his ancestral home in Igbo land.

Dr. Olumba presents the unique concept of cognitive immobility, exemplifying the internal conflict between longing for a place, the emotions of belonging to it, and the simultaneous desire to maintain a distance from it. It's about being physically mobile while feeling trapped in a particular place in the mind.

As he pushes for the recognition of this cognitive experience in migration studies, Dr. Olumba offers a new perspective to view experiences that have not received sufficient attention in the past. This episode is a valuable contribution to our understanding of cognitive migration processes and the emotional and mental experiences of those participating in human mobility.

Join us for this unique exploration of the less-examined aspects of migration and their implications on our understanding of human mobility.

Keywords: Dr. Ezenwa Olumba, cognitive migration, cognitive immobility, autoethnography, Igbo land, United Kingdom, migration studies, human mobility, mental journey.

The homeless mind in a mobile world: An autoethnographic approach on cognitive immobility in international migration. https://doi.org/10.1177%2F1354067X221111456

We usually think of an electron as having one form of kinetic energy, but what if it could have more? In this episode, we delve into the exciting world of electron interactions with Dr. Vianez, whose groundbreaking research focuses on the kinetic energy of an electron's spin and charge by exciting other electrons in a one-dimensional (1D) setting.

Dr. Vianez's work builds upon the Tomonaga-Luttinger model, a theory that successfully captures the physics of interacting electrons in 1D at low energies. However, experiments extending beyond this linear regime have been scarce. Through detailed tunneling spectroscopy measurements in 1D gated wires, Dr. Vianez and his team have observed separate Fermi seas for spin and charge excitations, challenging the traditional understanding of electron energy.

In addition, the team uncovered the emergence of two 1D "replica" modes, shedding light on a new dimension of electron interaction. Furthermore, they manipulated the interaction strength, altering the level of 1D intersubband screening and offering unprecedented insights into electron behavior.

This episode not only deepens our understanding of spin-charge separation in the entire energy band outside the low-energy limit of the Tomonaga-Luttinger model but also helps define the boundary of the newer, nonlinear Tomonaga-Luttinger theory.

Tune in as we journey into the intricate world of electrons with Dr. Vianez, pushing the boundaries of our understanding of quantum physics.

Keywords: Dr. Vianez, electron kinetic energy, Tomonaga-Luttinger model, spin-charge separation, one-dimensional gated wires, tunneling spectroscopy, Fermi seas, intersubband screening, nonlinear Tomonaga-Luttinger theory.

Observing separate spin and charge Fermi seas in a strongly correlated one-dimensional conductor https://doi.org/10.1126/sciadv.abm2781