Dr. Leang and team have developed a pioneering carbon-negative fermentation technique to produce industrial chemicals, specifically acetone and isopropanol, using waste gases like industrial emissions and syngas. Through extensive metabolic engineering and optimization strategies, the team was able to achieve production rates of up to 3 g/L/h and selectivity of ~90%. The approach not only sidesteps the use of sugars (a common but economically challenging feedstock) but also has the added benefit of utilizing greenhouse gases, thus mitigating their environmental impact.

Key Points:

Waste Gases as Feedstock: While sugar fermentation has its limitations due to scale and economic challenges, utilizing waste gases allows decoupling from commodity prices. This innovative process converts waste into ethanol using the acetogen C. autoethanogenum, setting the stage for production of other chemicals.

Enhanced Productivity: The team achieved impressive production rates and selectivity for acetone and IPA using engineered strains of the acetogen. This proves that acetogens can be optimized for high-efficiency chemical production.

Optimization Strategy:

Pathway Design: The team delved into a vast genomic library to find the best biosynthetic genes, resulting in significantly enhanced production.

Strain Engineering: Advanced engineering techniques, including multiple genome modifications, enabled the creation of a highly productive strain.

Pathway Bottleneck Analysis: A blend of omics measurements, kinetic modeling, and systems biology led to insights into pathway bottlenecks and their subsequent mitigation.

Scale-Up Success: Successful scale-up was achieved using a 120-L field pilot, underlining the commercial viability of the approach. Despite the challenges inherent to gas fermentation scale-up, the process showed robustness and adaptability.

Environmental Benefits: This fermentation technique has a twofold environmental benefit. Not only does it produce chemicals without relying on fossil fuels, but it also captures and uses greenhouse gases, thus reducing their atmospheric release. Life Cycle Analysis confirmed that this process results in a negative carbon footprint for the produced chemicals.

Towards a Circular Economy: By transforming waste gases into valuable industrial chemicals, this process exemplifies the principles of a circular economy. Rather than extracting fresh fossil resources, it promotes the recycling of carbon from various waste streams, paving the way for a sustainable and environmentally friendly chemical industry.

Implications:

The success of this research signifies a significant stride towards sustainable chemical production. The ability to transform greenhouse gases into valuable commodities not only addresses environmental concerns but also offers promising economic prospects. By bridging innovation in biotechnology with environmental responsibility, such processes can revolutionize the future of the chemical industry.

https://doi.org/10.1038/s41587-021-01195-w

Today's episode welcomes Dr. Nathan Lents, who shares enlightening revelations about the genetic foundation of what sets humans apart from other apes. Using an array of advanced tools and methods, Dr. Lents and his team embarked on a journey to uncover the mysteries of the human genome.

The Quest for Human Uniqueness:

The genetic underpinnings of our unique human traits remain an area of profound intrigue in biological anthropology.

Approach and Methods:

By employing genome alignment tools, the team aimed to find islands of DNA sequences that aren't conserved among species.

Further, they engaged in theoretical and computational examinations of these regions via synteny sequence analysis.

Discoveries on Human Chromosome 21:

The study unveiled families of microRNA genes present only in humans, with no discernible counterparts in other African apes.

These genes potentially play roles in the embryonic development of our central nervous system, setting the stage for distinctive neural growth and processes.

Origin of These Unique Genes:

The team postulated a fascinating model: these microRNA genes likely originated from repeated segmental duplication events within a field of rRNA genes.

This suggests an evolutionary adaptation, where a series of duplications generated entirely new microRNA genes.

Evolutionary Implications:

The unique 21p11 region of our chromosome 21 has seen duplication events that brought forth novel microRNA genes.

The modulation of genes linked to embryonic development by these microRNA genes could have significantly impacted our evolutionary path, possibly accounting for certain human-specific traits or cognitive capacities.

Conclusion:

Dr. Nathan Lents provides a captivating window into our genomic past, proposing that certain microRNA genes, birthed from a series of genetic duplications, might have influenced the very essence of our human journey. Such discoveries not only unravel the tapestry of our evolutionary history but also shed light on the nuanced genetic mechanisms that have sculpted our species.

Stay tuned for more intriguing episodes as we continue to explore the fascinating realms of science and discovery. Join us next time, and always keep the flame of curiosity burning bright!

https://doi.org/10.1002/ajpa.24504

In today's episode, we're diving deep into the mysterious world of ice structures with Dr. Salamat. By utilizing advanced techniques like X-ray diffraction and Raman spectroscopy, his research provides novel insights into the transitions and behavior of ice under extreme conditions.

Methods and Techniques:

The study combined the use of X-ray diffraction and Raman spectroscopy. Grain normalizing heat treatment was achieved via direct laser heating, ensuring precise results.

Transition from Ice-VII to Ice-VIIₜ:

At pressures around 5.1 ± 0.5 GPa, a transition was observed from cubic ice-VII to tetragonal symmetry, denoted as ice-VIIₜ.

H-Bond Symmetrization Transition:

A significant event in the H2O structure is the H-bond symmetrization transition. This occurs at a pressure of about 30.9 ± 3 GPa.

Supporting Evidence from Simulations:

The experimental findings were backed by simulated Raman spectra obtained from density-functional theory quantum calculations.

Significance of the H-bond Symmetrization:

The transition to H-bond symmetrization is marked by the reversible appearance of a distinct Raman mode.

Accompanying this, there's a 2.5-fold jump in the bulk modulus, indicating a substantial enhancement in bonding strength.

Conclusion:

Dr. Salamat's research paints a detailed picture of the intricate behavior of ice structures under high pressure. The discovery of the transitions in ice structures and the nuances of H-bond symmetrization adds depth to our understanding of the material properties and potential applications of such phases of ice.

Join us next time for another illuminating dive into the realms of science. Let's continue our journey of discovery and always strive to understand the wonders of the world around us.

https://doi.org/10.1103/PhysRevB.105.104109

Did you miss our guest speaker sessions? Is listening to hours of replays too time-consuming? Join us for the weekly recap rooms!

Today's episode delves into the captivating realm of neuromorphic electronics with expert Dr. Paschalis Gkoupidenis. He presents a groundbreaking exploration into emulating the brain's functional connectivity using organic neuromorphic devices.

The Brain's Dynamic Binding:

Neural populations in the brain synchronize through global oscillations, creating functional connectivity. This adaptability surpasses the hardwired structure, enabling complex, versatile computational systems.

Current Limitations in Neuromorphic Architecture:

Existing neuromorphic designs have yet to capture the fluidity of biological functional connectivity.

Functional Connectivity via Organic Neuromorphic Devices:

Arrays of organic neuromorphic devices were connected through an electrolyte.

Despite receiving independent stochastic inputs, the outputs synchronized with a global oscillatory input, akin to phase locking in the brain.

Analogies with Biological Networks:

Functional connectivity in the brain allows spatiotemporal coordination across regions through global oscillations.

The observed phenomena in the study resemble voltage oscillations stemming from synchronized neural ensembles.

Future Applications and Implications:

Introducing synchronization could offer more biologically realistic neuromorphic architectures.

Global oscillations can be used to modulate memory thresholds in an array of electrochemical devices, potentially enabling phase-dependent learning.

Concepts like traveling waves in electrolytes might pave the way for innovative neuromorphic designs.

The universality of electrolyte gating can be applied across diverse device materials.

These synchronization techniques have potential applications in bioelectronics, such as interfacing with biological cell cultures.

Conclusion:

Dr. Gkoupidenis illuminates the vast potential of organic neuromorphic electronics. By closely mirroring the brain's dynamism, these devices could revolutionize how we approach computing, data processing, and even bioelectronics. The future beckons with the promise of devices that aren't just inspired by the brain but replicate its intricate mechanisms.

As we step into a future melding technology with biology, let's remain curious and inspired. Join us again as we explore more pioneering research and innovations in the world of science.

https://doi.org/10.1002/aisy.201900013

Today, we venture into the intricate world of creativity with Dr. Fletcher. As an essential source of innovation and adaptability, understanding creativity has become vital for numerous sectors. Join us as Dr. Fletcher introduces an alternative approach to understanding and training creativity through narrative theory.

Reevaluating Creativity Training:

Creativity's value is undisputed; yet, the foundational training technique, divergent thinking, has its limitations. Concerns include its incongruence with the creative processes observed in children and many adults, and its underwhelming results.

Introducing Narrative Theory to Creativity:

Dr. Fletcher proposes narrative theory as a fresh perspective to advance our understanding of creativity. It offers a comprehensive mechanism that aligns with J.P. Guilford's demystification of creativity but expands upon it.

Addressing Gaps in Current Creativity Theory:

Divergent thinking doesn't explain children's creative processes, leading to a schism between child and adult creativity research.

Narrative theory can bridge this gap and unify the field by translating insights from child creativity studies to adult contexts.

Practical Implications of Narrative Theory:

Narrative theory pinpoints divergent thinking's limitations while promoting existing methods that nurture children's creativity.

The approach suggests new, assessable training techniques. Early adoption by the U.S. military and other major institutions indicates its practical relevance.

Expanding the Horizons of Creativity Training:

Guilford's traditional divergent thinking approach remains valid; narrative theory simply offers an expansion, recognizing creativity's reach beyond computation.

Emphasizes the role of action-based neural processes in creativity, evident in children's "possibility thinking" and prevalent in adult innovations.

Conclusion:

Dr. Fletcher makes a compelling case for the integration of narrative theory into our understanding and training of creativity. By acknowledging the limitations of divergent thinking and the potential of narrative theory, we can reshape how we nurture creativity across all age groups, leading to transformative impacts in various domains, from national security to personal growth.

As we continue our exploration into the depths of human creativity, Dr. Fletcher's insights offer a beacon for future research and training methods. Stay tuned for our next episode where we unravel another exciting facet of human cognition.

https://doi.org/10.1111/nyas.14763

Today, we delve into a groundbreaking frontier in bio-imaging with Dr. MacKenzie, who is pioneering methods to observe and understand the world of chiral molecular interactions – an area that, up to now, was challenging to visualize.

The Significance of Chirality:

Life's molecular machinery relies on chiral building blocks, yet monitoring these in live cells remained elusive.

Luminescent chiral molecules provide a unique optical signature, shedding light on the environment, shape, and binding state.

Introducing the CPL Laser Scanning Confocal Microscope (CPL-LSCM):

This revolutionary device can capture chiroptical contrast in live-cell imaging of both natural and designed CPL-active cellular probes.

Achievements also include the success of using two-photon excitation, fully restoring the CPL spectrum in the process.

Major Breakthroughs:

CPL-LSCM System: This breakthrough allows for rapid, diffraction-limited enantioselective chiral-contrast imaging, advancing the sub-cellular tracking of emissive chiral probes.

2PE-CPL Spectroscopy: Proves that low-energy 2PE-CPL-LSCM is primed for future advancements.

Test Target for Enantioselective Chiral-Contrast Imaging: A standard tool was developed using enantiopure solutions of a europium complex to benchmark future imaging systems.

Imaging Specific Enantiomers: Imaging of distinct enantiomers of a chiral europium complex within mouse skin fibroblast cells showed significant co-localisation with standard lysosomal and mitochondrial tracker dyes.

Potential Impacts & Applications:

Set to transform fundamental studies in chemistry and molecular biology.

Can aid in advancing the design of chiral bio-probes.

In material sciences, applications extend to 3D display technologies and the verification of innovative CPL-active security inks.

Conclusion:

Dr. MacKenzie's innovations herald a new era in bio-imaging, offering researchers unprecedented insights into the world of chiral interactions. By capturing the essence of life's foundational chiral processes, CPL-LSCM provides a beacon for myriad future discoveries in the intertwined realms of chemistry, biology, and materials science.

As we shine a new light on the intricacies of life's molecular dance, we eagerly await the future revelations this field holds. Join us next time for more groundbreaking research insights into the world of science.

https://doi.org/10.1038/s41467-022-28220-z

Join us today with Dr. Pedram Roushan from Google Research as we dive deep into the world of quantum many-body systems. We'll explore the fascinating phenomena of dynamical phases and the concept of discrete time crystals (DTC), revealing the wonders of out-of-equilibrium quantum systems.

Nature's Non-equilibrium State:

Quantum many-body systems have rich phase structures in low-temperature equilibrium states.

However, nature often exists out-of-equilibrium, leading to intriguing dynamical phases not seen in equilibrium.

The Novelty of Dynamical Phases:

Recent predictions suggest dynamical phases might exist that are forbidden by conventional equilibrium thermodynamics.

A prime example is the discrete time crystal (DTC).

Understanding Eigenstate Order:

Dynamical phases in periodically driven many-body-localized (MBL) systems are defined via eigenstate order.

These MBL phases display quantum correlations and long-range order across the entire many-body spectrum, resulting in unique late-time dynamics.

Challenges and Experimental Achievements:

It's tough to differentiate stable phases from temporary phenomena in experiments.

Dr. Roushan's team utilized controlled-phase (CPHASE) gates on superconducting qubits, allowing them to observe an MBL-DTC and its unique spatiotemporal response.

Time-Reversal and Quantum Typicality:

The team employed a time-reversal protocol to gauge external decoherence effects.

Leveraging quantum typicality, they overcame the exponential challenge of sampling the eigenspectrum densely.

Discovering the Phase Transition:

The team identified the transition out of the DTC through a finite-size analysis, paving the way for future quantum processors.

Conclusion:

Dr. Pedram Roushan's groundbreaking work offers a fresh perspective on understanding quantum many-body systems and non-equilibrium phases of matter. By uncovering the mysteries of the discrete time crystal and its associated dynamical phases, we move a step closer to realizing the full potential of quantum processors.

Quantum mechanics never ceases to amaze, and with pioneers like Dr. Roushan leading the way, the future of quantum research looks brighter than ever. Stay with us for the next episode, where we continue our journey into the quantum realm.

https://doi.org/10.1038/s41586-021-04257-w

Did you miss our rooms? Did you have more questions comments that we didn’t have time to clarify? Join our weekly recap rooms! We will give a summarized overview of what our guest speakers presented.

In today's episode, we're joined by Dr. Chen to discuss a pressing concern for the elderly: dementia. As one of the primary causes of death among senior Western populations, the race is on to find treatments or preventive measures for dementia. Dr. Chen enlightens us about an intriguing potential solution: lithium.

The Dementia Dilemma:

Dementia stands as a dominant cause of death in elderly Westerners.

Despite extensive research, no disease-modifying treatments are currently available.

Lithium: A Potential Answer?

Lithium, typically known for its psychiatric applications, has been proposed as a possible treatment for dementia.

Study Design and Methodology:

Dr. Chen's team carried out a retrospective cohort study spanning 15 years using electronic clinical records from secondary care mental health services in the UK.

The main aim was to understand the relationship between lithium use and dementia onset, focusing on specific subtypes of the condition.

Key Findings:

Out of 29,618 patients studied, 548 had been exposed to lithium.

Notably, lithium-exposed patients had a significantly lower risk of developing dementia, including both Alzheimer's disease and vascular dementia, when factors like demographics and physical comorbidities were controlled.

Both short-term and long-term lithium users exhibited this reduced risk, hinting at the potential protective power of the element.

Addressing Limitations:

The primary challenge was managing the overlap between bipolar affective disorder (BPAD), a frequent reason for lithium prescription, and dementia, since BPAD is also a risk factor for dementia.

Although the sample size for lithium users was relatively small, the findings remained consistent across multiple analyses, bolstering their reliability.

Implications and Future Directions:

These results suggest lithium may be more than just a psychiatric drug; it might play a role in preventing or even treating dementia.

The findings pave the way for more expansive, randomized controlled trials to validate and expand upon these results.

Conclusion:

The link between lithium use and a reduced risk of dementia offers a beacon of hope in the long-standing battle against this debilitating condition. As Dr. Chen emphasizes, further research is essential, but the initial findings are promising and hint at a brighter future for dementia prevention and treatment.

A big thank you to Dr. Chen for sharing this groundbreaking research with us. Stay tuned for our next episode, where we continue to explore the forefront of medical research.

https://doi.org/10.1371/journal.pmed.1003941