Discover how a target identified in colon cancer research led to an unexpected opportunity to protect brain cells and preserve cognition in mouse models of Alzheimer’s and head trauma. Sanford Markowitz, MD, PhD, and Andrew Pieper, MD, PhD, describe the translational path, mechanistic insights into neuroinflammation and neurogenesis, and what’s needed for human trials.

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• Learn more about Andrew Pieper, MD, PhD
• Learn more about Sanford Markowitz, MD, PhD
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Adonis Hijaz, MD and Goutham Rao, MD discuss the reasons why urinary incontinence is underreported and actionable strategies clinicians can use to start the conversation in primary care. They outline the EMPOWER model, from large-scale screening to nurse navigators and pelvic floor physical therapy, and why that pathway increases treatment rates.

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Explore the rapidly evolving world of CAR T-cell therapy and how scientists are reengineering the immune system to fight disease. Drs. David Wald and Reshmi Parameswaran discuss breakthroughs in cancer immunotherapy, including faster manufacturing, next‑generation CAR T-cell design, and efforts to expand these therapies from blood cancers to solid tumors and autoimmune diseases. This conversation highlights the promise and challenges of bringing these innovative treatments to patients.

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The pace of change in cardiometabolic medicine is accelerating. Ian Neeland, MD, breaks down the latest innovations in incretin therapies, from oral medications to cutting-edge combinations, and what they mean for weight loss, heart health, and long-term patient care.

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Matthew Anderson, MD, PhD, and Tyler Miller, MD, PhD, discuss how immune biology is reshaping neuroscience - from autism and obesity to CAR T cell therapies for glioblastoma and the challenge of crossing the blood brain barrier.

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Jennifer Villwock, MD, explains the neurocircuitry of smell, her rapid essential-oil–based AROMA test, and how olfactory dysfunction can inform clinical care and research spanning sinonasal disease, post-viral loss, and cognitive health.

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Molly McVoy, MD, dives into the mental health crisis affecting teens, why anxiety and depression have risen dramatically, and shares breakthrough research using EEG biomarkers and self-management programs that help teens build resilience.

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Theodoros Teknos, MD, and Gary Schwartz, MD, discuss how the recent $25.5 million NCI grant renewal solidifies Case Comprehensive Cancer Center as a powerhouse consortium delivering cutting-edge clinical trials, early detection and community-focused cancer prevention across Northeast Ohio.

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Join Dr. Daniel Simon as he interviews Dr. Igho Ofotokun, Chair of the Department of Medicine at University Hospitals. Dr. Ofotokun shares his remarkable journey from Nigeria to becoming an expert in HIV research, revealing how passion and experiences shaped his career in infectious diseases. Discover the pivotal moments that guided him in the fight against not just HIV, but also the challenges posed by COVID-19.

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• Learn more about Igho Ofotokun, MD, MSc
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Join Dr. Daniel Simon as he explores the groundbreaking collaboration between Dr. Sanford Markowitz and Dr. Andrew Pieper. Discover how their combined expertise in cancer genetics and psychiatry is leading to innovative approaches that tackle Alzheimer’s and traumatic brain injury, providing hope and insight to those affected by these devastating conditions.

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• Learn more about Andrew Pieper, MD, PhD
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