SciPod

Most human diseases are localised in terms of their location but currently, injected or orally administered drugs are evenly distributed all over the body and thus, act indiscriminately. The targeted delivery of medication to the exact site where it is needed is a common theme in science fiction but thanks to Professor Richard Klemke and his team at the University of California San Diego’s Moores Cancer Center, this fantasy may soon become a reality.

Although human immunodeficiency virus (HIV) is still prevalent worldwide, life-saving antiretroviral drugs can now prevent an infection from progressing into acquired immunodeficiency syndrome (AIDS). Nevertheless, people who are HIV-positive are still at increased risk of developing neurological disorders and cardiovascular diseases, known as co-morbidities. Professor Michael Bukrinsky from the George Washington University in Washington DC works to understand the underlying biological mechanisms that lead to these disorders. His research has produced interesting results that demonstrate the role of altered lipid (cholesterol) homeostasis in HIV-infected cells and how this comes to pass.

People who live close to busy roads and highways are exposed to high levels of traffic-related air pollution. This puts them at risk of significant health difficulties such as high blood pressure, heart attacks and cancer. The Community Assessment of Freeway Exposure and Health Studies led by Dr Doug Brugge from the University of Connecticut represent community-engaged research into the biological impact of high exposure to pollution and importantly, possible solutions to this. This work has shown that high-efficiency particulate arrestance filters are one promising intervention for minimising exposure to pollution and thus improving health.

Epilepsy is a chronic, long-term disease in which abnormal activity in the brain leads to repeated seizures, and it affects nearly 70 million people worldwide. The exact mechanisms behind epileptic seizures are still poorly understood. However, we do know that epilepsy can be caused by changes in the network structure of our brains and that seizures may be a result of spontaneous excessive brain synchronisation. Professor Eckehard Schöll and his Master student Moritz Gerster together with colleagues are using computer simulations to better understand the interplay of network structure and network synchronisation in epilepsy.

Non-human primates play crucial roles in sustaining natural ecosystems worldwide. However, approximately 68% of primate species are now at risk of extinction, mainly due to agriculture and the depletion of natural resources. Dr Alejandro Estrada at the National Autonomous University of Mexico, Dr Paul A. Garber at the University of Illinois-Urbana, and a group of scientists from various parts of the world recently carried out a study to better understand the role that Indigenous Peoples play in the conservation of threatened primates.

Addressing the skills shortage within scientific sectors requires a targeted approach for attracting and retaining students in STEM education. Summer Opportunities in Agricultural Research and the Environment (SOARE), SOARE: Strategic Work in Applied Geosciences (SWAG) and AgDiscovery, three innovative programs at the University of Maryland, provide a gateway for continued education, particularly for students who are traditionally under-represented in scientific fields. Implemented by Dr Evelyn Cooper, the success of the AgDiscovery and SOARE programs at the university has led to the inception of the new SOARE:SWAG program. Co-directed by Dr Candice Duncan, SOARE:SWAG focuses on students within geoscience disciplines.

Our intestines contain millions of bacteria, known as our microbiota, which secrete compounds and play a key role in keeping us healthy. These bacteria don’t just affect the health of our digestive system, they can influence organs as far away as the brain. Dr Francesca Ronchi at Charité Universitätsmedizin in Berlin is determining the role of the microbiota in the prevention and development of neurological disorders.

The perspectives and characteristics of specific historical periods are often reflected in the literary texts produced and circulated at the time. Dr Andrea Binsfeld, an Associate Professor at University of Luxembourg, has conducted several studies examining narratives of slavery in ancient texts, including novels and political discourses. Her analyses outline, from a different perspective, the deep impact that the institution of slavery had in Greek and Roman societies.

Dr Lars Oddsson, CTO of RxFunction and Adjunct Professor at the University of Minnesota is co-inventor of a wearable device called Walkasins® to help improve balance and reduce the risk of falls in people with sensory peripheral neuropathy. The walk2Wellness trial incorporated five clinical sites where they demonstrated that by replacing sensory stimulation for balance, this prosthetic device can have a positive impact on clinical mobility outcomes and quality of life for those who have suffered nerve damage causing loss of sensation in their feet.

The Hilbert space formulation is a central idea in quantum theory, but the ideas used by physicists to interpret the formulation widely differ. Furthermore, concepts in quantum mechanics are very abstract to those outside the field. Professor Inge Helland from the University of Oslo approaches these problems through what he calls ‘conceptual variables’, which belong to the minds of one or more conscious observers. From this basis, he achieves a new derivation of the Hilbert space formulation, which he hopes will lead to more satisfying studies of the foundations of quantum theory.