In the second hour, Mark Grote welcomed on Ryan McGuffey of NBC Sports Chicago to discuss the White Sox's 8-4 loss to the Mariners on Wednesday afternoon and the concerns associated with manager Tony La Russa's decisions in the team's 3-4 start. Later, Score baseball insider Bruce Levine joined the show to discuss the Cubs' offensive struggles in their 3-3 start.

Sitting in for Joe Ostrowski, Mark Grote opened his show by reacting to the Cubs' 4-2 loss to the Brewers in 10 innings on Wednesday afternoon. Later, NBC Sports Chicago play-by-play man Adam Amin joined the show to discuss the Bulls' two-game winning streak.

In the final hour, Mike Esposito was joined by Bulls Radio analyst Bill Wennington to preview Chicago's game at Phoenix later in the night and to discuss three key players being out with injuries.

In the second hour, Mike Esposito was joined by PointsBet head of trading Jay Croucher to discuss the new MLB season from a gambling perspective. Tony Andracki of the Marquee Sports Network then joined the show to preview the Cubs' outlook for the new season. Later, James Fox of Future Sox joined the program to discuss the White Sox's lofty expectations in 2021 and what it will take to achieve them.

Sitting in for Joe Ostrowski, Mike Esposito opened his show by listening and reacting to Cubs president of baseball operations Jed Hoyer's comments expressing strong confidence that the organization will sign first baseman Anthony Rizzo to a contract extension. After that, he discussed the news that White Sox top prospect Andrew Vaughn will be in the Opening Day lineup -- but at designated hitter, not in left field. Later, Score baseball insider Bruce Levine joined the show to discuss the latest Cubs and White Sox storylines as their season openers loom Thursday.