Adam ate the sacrifice which resulted in the curse. Agravation, frustration, denial, and depression, etc... originated in the Garden of Eden.
God still requires a sacrifice. Genesis 3:15, the Seed of the woman becomes the sacrifice. Genesis 3:21, God sheds the blood of innocents animals to cover their sin. In this short video, I take you sacrifice showing how God used the sacrifice to restore the original blessings of Genesis 1:28