Sean Glynn leads patient engagement and evidence programs at Noble, a division of Aptar Pharma. Sean joins Jim Joyce and Eugene to unpack why he thinks medication adherence still isn't solved, and why he'd retire the word "adherence" altogether. His team's SureStart Rx program moved injection training out of doctors' offices and into specialty pharmacy workflows, and the pilot data holds up: 88% patient usage, first doses 3.5 days sooner, and one to two extra doses over six months. Sean also traces the winding path that got him here: organizational behavior grad school, a house-flipping business, pharmacoeconomics at the University of Florida, Health Beacon, and ZS Associates.

00:00 - Cold Open - The Dose Is the Poison
02:00 - Meet Sean Glynn - Noble, Aptar, and a Decades-Long Friendship
04:00 - Irish Roots and the Family That Reverse-Immigrated Twice
09:00 - Delicate Hands to Org Behavior - Finding the Thing
13:00 - The Metric Pharma Got Wrong - Commitment Beats Satisfaction
18:00 - The Construction Detour, and How Health Beacon Started
23:00 - ZS Associates, WHOOP, and the Integrated Evidence Plans
26:00 - Dying on the Vine - Why Evidence Plans Get Skipped
30:00 - The Noble Pivot - SureStart Rx and the Distribution Problem
35:00 - Becoming an Intrapreneur Inside a 9-Billion-Dollar Company
38:00 - Why Injections Are Still Genuinely Hard
40:00 - The Ozempic Story, Cold Plunges, and Ronaldo's Free Kick
44:00 - Killing the Word "Adherence"
48:00 - Where Noble Goes Next - AI, Sensors, and Global Expansion
50:00 - Closing Question - Advice to His Younger Self

Guest: Sean Glynn, Noble / Aptar Pharma - LinkedIn | Noble | Aptar Pharma

Mentioned in this episode: Sean McDade and PeopleMetrics, Craig Baker and Jeff Baker (Noble's founders), BioPlus Specialty Pharmacy, WHOOP, ZS Associates, Health Beacon, University of Florida.

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In this episode of #TheShot of Digital Health Therapy, Jim Joyce and I sit down with Jonathan Anderson, CEO of Nothing Artificial. Thoroughly enjoyed reconnecting and chatting across numerous topics:

-The Door-to-Door Sales Rule: What Jon learned in his early days of selling home water systems to households (Hint: make sure all the decision makers are present at once)

-The Enterprise Arbitrage: How Jon acquired UCB Pharma’s FDA-registered Nile.ai platform turning enterprise infrastructure into a commercial launchpad.

-The DTx Graveyard Realist: Why Akili and Pear struggled, and why digital therapeutics must shift from standalone "disease apps" to cognitive infrastructure embedded directly into pharma pipelines and everyday hardware.

-Economic Inevitability vs. Hype: Why health systems don't adopt tech because it's novel or slick - they adopt when friction drops to zero and the business model becomes mathematically unavoidable.

Ready to hear how real health-tech deals get structured when the PR filter is off? Listen to the full episode on Spotify, Apple Podcasts, or YouTube below (links are in the comments) ! 👇

Fun mentions as always: Pia Clinton-Tarestad, Dominick Kennerson, Anil S Jina, MD , Eddie Martucci, David Benshoof Klein, Cris De Luca ⚽️, William Taranto

In this episode of #TheShot of #DigitalHealth Therapy, Jim Joyce and I sit down with Pia Clinton-Tarestad, CEO of Clean Slate Clinic

We poke at the sacred cows of legacy addiction care, the high-touch operational pipes of virtual detox, and the deep cultural stigma that keeps high-functioning corporate leaders suffering in silence.

Few topics we discussed:

The Anxious Overachiever Trap: Why the high-stakes, competitive "bell-curve" mechanics of consulting and corporate leadership act as a massive incubator for hidden coping mechanisms like alcohol dependence.

The Fallacy of the Legacy Inpatient Stay: Why legacy inpatient rehab is highly fragmented and structurally designed for relapse, and how a continuous, 12-month virtual-first support model delivers outcomes that are an order of magnitude better.

The Human-in-the-Loop Protocol: Why pure-software wellness apps and low-touch "pill-mill" virtual clinics fail, and how training a patient's immediate personal network (family & friends) creates a scalable, clinical safety net for at-home medical detox.

Are we ready to stop funding highly fragmented, low-efficacy options and actually scale real, long-term behavioral recovery?

Let us know your thoughts in the comments.

Fun mentions as always: Peter Greaney M.D., Dave Sagar

In this episode of The Shot of Digital Health Therapy, Jim Joyce and I sit down with Bart De Witte. Bart is a former dentist turned corporate heavyweight (SAP and IBM before becoming a radical advocate for open-source AI. He’s the founder of a non-profit (Hippo AI Foundation) dedicated to freeing medical data and is now building Isaree, a platform aimed at becoming the "Android for Medical Intelligence".

In this episode of #TheShot of #DigitalHealth Therapy, Jim Joyce and I sit down with Yang Su and Xing Su, co-founders of Seen Health. This is the first time EVER we had twin founders on the show so was fun to find out who actually came out first and what it takes to run a business together. The two brothers were "tech & consultancy royalty", who had never touched a medical record until their own family needed help. Now, they are proving that the biggest innovation in healthcare isn't a new algorithm (though their platform is a key ingredient to scale); it's a "one-stop-shop" center where a doctor, a physical therapist, and a hot meal are all down the same hallway and a community are all a big part of being "seen".

The 4 Pillars of the Seen Health Thesis:

-The "Roadster" Framework: Why you must start with the $100k-per-year, high-frailty "Roadster" model to build the infrastructure that will eventually drive costs down to $1k-per-month for everyone.

-The Operator’s Edge: Why having "outsider" eyes allowed them to see that 70% of senior care is actually logistics, transportation, and nutrition - not just medicine.

-The Focus Trap: Why they turned down "easy" revenue from selling their software to stay "unapologetically" focused on the elderly patient in front of them.

-Hospitality as Medicine: Borrowing the "Ritz Carlton" philosophy to ensure seniors feel "seen" rather than processed by an institution.

Fun mentions as always: Erik Milster, Elon Musk, The Ritz-Carlton Hotel Company, L.L.C., Tesla, Uber, Salesforce, Google, Coursera, Andrew Ng

[00:02:40] The 3-Minute Birth Gap: Why being the "older" twin created a lifelong competitive rub.

[00:09:00] The "Silicon Valley Dream" vs. Reality: Leaving Google and Stanford's Andrew Ng to find "scars" in the real world.

[00:16:10] The Magical Twin Synchronicity: How Uber and Quip were both acquired on the exact same day, charting a course back to each other.

[00:18:20] Discovering PACE: Why a 50-year-old model from San Francisco’s Chinatown is still the gold standard.

[00:25:20] The San Gabriel Valley Bet: Why they chose hyper-focus over "general" scaling.

[00:32:40] The Tesla Roadster Analogy: How to scale high-touch care by driving the "blueprint" cost down from $100k.

[00:43:00] The EHR From Scratch: Why they built their own tech stack instead of buying "off the shelf".

[00:47:30] The Refusal to Commercialize: Turning down tech revenue to protect the patient experience.

[00:51:50] The Closer: "Unapologetically yourself"—advice to their younger twin selves.

In this episode of #TheShot of #DigitalHealth Therapy, Jim Joyce and I sit down with Carl Bradford Byers 🚑 . Carl is a Partner at F-Prime who was previously CFO of athenahealth and helped scale the company from a basement startup to an IPO. He’s one of the few venture capitalists who actually knows how to build the pipes, not just pitch the vision.

What we get into:

-The 4 AI Agents of Your Health: How Carl sees the future of agentic AI in health care

-The Investment Thesis: Why "smart money" is actually about finding the partner who will sleep in your office to vet the code

-The IPO Scars: The reality of scaling to a publicly traded company and the growth mindset (aka survival instinct) required to stay alive.

Links to watch / listen below in comments 👇

Fun mentions as always: Daniel Kendall, Marina Borukhovich, Jonathan Bush, Todd Park, Ed Park, Paul Markovich, Chris Dixon, Owen McCarthy, Eric Paley, Brian Roberts, Glen Tullman, John Hallock, Matthew Holt, Indu Subaiya, MD, MBA, MFA

[00:02:45] The "Log Cabin" Intro: Carl’s roots and meeting the Athena founding team at Wesleyan.

[00:05:30] The War Room: Driving Bill Clinton's van and the intensity of political "advance" work.

[00:12:30] The Athena Basement: Why Carl chose a "basement startup" over a prestigious Chicago MBA.

[00:16:45] The 4 Pillar Thesis: Breaking down the Clinical, Technical, Financial, and Operational requirements for health-tech.

[00:18:45] The Investment Thesis: How Brian Roberts and Venrock vetted the early tech by sleeping in the office.

[00:21:00] The President on the Phone: Securing an early $50k from George H.W. Bush.

[00:24:00] Scars of the IPO: The transition from a "silly toy" to competing with giants like GE and McKesson.

[00:57:00] The Madrid Ad: Why the "Who" is the only thing that survives a 20-year career.

In this episode of #TheShot of Digital Health Therapy, my regular co-host Jim Joyce passed the bouton to Daniel Kendall who was kind enough to step in. Dan and I sat down with Margaret Moore aka Coach Meg. As the founder of Wellcoaches and the co-founder of the Institute of Coaching as well as National Board for Health & Wellness Coaching, she pioneered the professional standards for health & wellbeing coaching. As we always say.... to be a Key Opinion Leader (KOL) you need to have opinions AND backed by data! Meg brings it all to our discussion:

-Why telling people what to do is the least effective way to change them.

-The Science of Coaching: How Margaret shepherded coaching from a "soft skill" to a science-backed discipline.

-Using "Parts Work" to navigate the voices in our heads that resist change.

-Human-Centered AI: Why healthcare needs a "coaching chip" inside the machine.

-Will Centers for Medicare & Medicaid Services (CMS) adopt coaching as part of the chronic disease management framework?

If you’re trying to move the needle on patient outcomes, Margaret explains why the relationship is the medicine. Links in comments.

Fun mentions as always: Ruth Q. Wolever, PhD, NBC-HWC Gary Sforzo Marina Borukhovich Dr Mehmet Oz, RFK Jr.

04:30 – The Business vs. The Creative: How Margaret transitioned from Biotech C-Suite to "Coach Meg."

17:00 – Professionalizing Coaching: Building the Institute of Coaching and the NBHWC standards.

23:15 – The CMS Update: Framing coaching for Medicare coverage and the "dose response" of behavior change.

34:10 – The Paradigm Shift: Why the Annual Wellness Visit needs to start with "What are your health goals?"

45:30 – Mapping the Mind: Using biology to create a unified framework for the human psyche.

51:20 – The 15-Year-Old Self: A personal revelation on reclaiming flow and leadership.

Stop building "interesting" digital health apps that nobody buys. Bruce Hellman (uMotif) joins Jim and Eugene to reveal why "interesting" is the kiss of death for scaling in healthcare.

We dive into the pivot from "crushing" civil service bureaucracy to finding "must-have" budgets in Global Pharma and Clinical Trial research. Explore the Mortar Theory of patient data and how to build for the "Citizen Scientist".

Always Fun Mentions:

Instagram Muscles: Eugene’s quest for a 15-second handstand.

Dubai Roots: Bruce as the first male born in Sharjah.

Essex County: Britain’s "finest" county.

The Ski-Rep Era: 100+ days of career-building on the slopes.

Chapters:

As always - we are meticulously unproduced.

What does it actually take to build a healthcare company from scratch?

In this episode of #TheShot, Eugene Borukhovich and Jim Joyce sit down with Daniel Kivatinos, co-founder of DrChrono, to unpack a real founder journey — from growing up in Queens with blue-collar parents to bootstrapping a healthcare startup through the 2008 crash, betting early on the iPad, and building DrChrono over 13+ years before selling in 2021.

This is not a “how to get rich quick” story.

We talked about:

🧱 Start painfully small - One doctor who loves your product beats 1,000 lukewarm users

🔁 Release fast, fix faster - Daily shipping built trust doctors didn’t get from incumbents

🕰️ Timing is earned, not predicted - Years of grinding made the iPad moment possible

💸 Bootstrapping builds discipline - Scarcity forced focus

🚫 Ignore most advice - Especially from people who aren’t where you want to be

🏃‍♂️ Just do it - Overthinking kills more startups than bad ideas

If you’re building in healthcare, fintech, or any regulated industry — this one’s for you.

👍 Like

00:00 – Intro & JP Morgan recap
01:30 – Why Eugene can’t do the show without Jim
02:10 – Meeting Daniel at Health 2.0 in NYC
03:10 – Growing up in Queens
05:00 – Blue-collar parents & elevator mechanic stories
07:00 – Stony Brook, choosing computer science, brutal CS class
09:30 – Art, music, and coding
11:00 – Early startups that failed
12:30 – The 2007–2008 reality check
14:00 – Why Daniel didn’t chase “safe” jobs
16:00 – Watching friends raise money & choosing a harder path
18:30 – Saving $50k and deciding to start a company
20:00 – Why healthcare
21:00 – Founding DrChrono
22:00 – What DrChrono originally solved (scheduling)
23:30 – Printing flyers & knocking on doctor doors
25:30 – One doctor who truly loved the product
27:30 – “10 users who love you beats 1,000 who don’t”
28:30 – Expanding into EHR, billing, and practice management
29:30 – Hearing about the iPad
30:30 – Building the first iPad-based EHR
31:45 – Overnight growth after the App Store launch
33:00 – Releasing faster than Epic and Cerner
35:00 – Why speed mattered more than strategy
36:00 – Cold-emailing Y Combinator
37:00 – Alexis Ohanian visits NYC
38:30 – Startup School & mindset shift
39:30 – The YC interview experience
40:30 – Getting the first real check
41:30 – Life inside Y Combinator
43:30 – Growing DrChrono over 13+ years
44:30 – Selling to EverCommerce in 2021
45:30 – Why the buyer mattered more than the price
46:30 – What Daniel is building now (JustPaid)
48:00 – Why starting SMB beats selling enterprise first
49:30 – Final question: advice to younger self
52:00 – “Just do it. Don’t stop.”

#TheShot of #DigitalHealth 2026 episode almost didn’t happen - Jim Joyce was in the air, I was back in cold New Jersey, and Max was somewhere warm and productive (naturally). But missing it would’ve been a mistake.

Max Marchione, founder of Superpower, joined me for a wide-ranging conversation on why modern healthcare is fundamentally broken - and why diagnostics, AI, data, and first-principles thinking might finally fix it.

We talked about:

- Growing up with chronic health issues no doctor could explain

- Why “10x doctors” exist - and why most medicine can’t scale them

- How AI will soon outperform humans at clinical reasoning

- And what it actually takes to scale a healthcare startup without losing your soul

This wasn’t a polished healthcare panel. It was a real conversation about truth, tradeoffs, and taking massive action - even when you know you’ll mess some of it up.

If you’re building in health, longevity, AI, or just trying to feel better in your own body… this one’s worth your time.