I have beaten Ascension Level 10 with The Necrobinder, The Ironclad and The Silent, in that order. My total playtime with each of those characters are 29h47m, 20h00m and 31h15m, respectively. I've now played 72h38m with The Regent, and I've still not been able to defeat Ascension Level 10. I've reached the double bosses a few times, but mostly don't get that far. I know it's supposed to be VERY HARD, but if even this really nice deck, with quite a few very hard-to-achieve synergies isn't enough, maybe it needs a little tweak? I think the new boss, the Aeonglass, is a little bit too punishing with how fast it fills your deck with Wither status cards.