In his sermon on John 6:22-29, Pastor Johnnie Sloan emphasizes the significance of believing in Jesus as the Son of God and placing God's glory above personal desires. He addresses the necessity of accurately interpreting biblical texts, cautioning against imposing personal interpretations onto scripture. Pastor Sloan highlights the moment when Jesus confronts a crowd that seeks Him solely for physical bread, revealing their selfish motives. He underscores Jesus' acceptance of all individuals and the importance of faith as a divine gift. The sermon stresses the need to seek the "bread of life" that truly satisfies eternal hunger, encouraging listeners to prioritize their relationship with God through Jesus Christ.