Springer Nature

In this episode, Dr Sara Nilson (University of Nebraska–Lincoln), Dr Jared Decker (University of Missouri) and Prof. Leslie Lyons (University of Missouri) discuss their quest to find the geographical origins of cat domestication.

This episode explores the recent Heredity paper: “Genetics of randomly bred cats support the cradle of cat domestication being in the Near East” https://www.nature.com/articles/s41437-022-00568-4

Although prophylactic lymph node dissections do not improve survival, the prognostic implications of a positive sentinel node and the benefi ts of removing nodal metastases for loco-regional disease control remain important. There is a strong interest in novel approaches that can improve patients’ selection for sentinel lymphnode biopsies (SLNB) given that 85% of these procedures are negative and non-therapeutic. The host discusses with Dr. Alexander Meves his recent review in Modern Pathology on the role of gene expression profiling in this setting when combined with clinicopathologic parameters.

After a traumatic event, women are more likely to be diagnosed with post-traumatic stress disorder, or PTSD. Research has been conducted on what might be causing this higher rate of diagnoses; for instance, perhaps women had more cumulative trauma in their lives than the men in question. But scientists say that even taking prior childhood trauma into account, women are still diagnosed at a higher rate than men.

Alyssa Roeckner is a neuroscience PhD candidate at Emory University, she’s in the lab of Dr. Jennifer Stevens, assistant professor in the department of Psychiatry and Behavioral Sciences at Emory University. They are two of the authors of a recent study in NPP titled “Sex-dependent risk factors for PTSD: a prospective structural MRI study.”

Read the full study here: https://www.nature.com/articles/s41386-022-01452-9

Flat lesions of the urothelium with histologic features that falls short of the threshold for urothelial carcinoma in situ (CIS) remains a challenging problem in diagnostic surgical pathology. Among these are flat urothelial hyperplasia, urothelial dysplasia, and atypia of unknown significance; lesions that have struggled under evolving classifications, changing criteria, and limited clinical actionability, all confounded by the recognized lack of diagnostic reproducibility.

In this episode of ModPath Chat, Dr. Gladell Paner discusses with the host his recently published “Controversies in Pathology” article in Modern Pathology on the pros and cons of keeping the previous terminology of this group of lesions.

In this episode, Dr Paul Maier tells us about his research on the landscape genetics of the Yosemite toad, which only inhabits high-altitude meadows in California’s Sierra Nevada Mountains.

This episode explores the recent Heredity paper: “Landscape genetics of a sub-alpine toad: climate change predicted to induce upward range shifts via asymmetrical migration corridors” https://rdcu.be/cYehZ

95% of adolescents in the US have access to a smartphone and 45% report being online "almost constantly". Beyond the general time spent on screens, the control over usage and the interference into other activities are also important considerations and could reflect problematic screen use.

This week on Pediapod, we meet Early Career Investigator, Professor Jason Nagata from the University of California, San Francisco to discuss his recent study of the sociodemographic correlates of problematic screen use.

Read the full article here: https://www.nature.com/articles/s41390-022-02176-8

Locally recurrent prostate cancer from 53 patients that failed radiation therapy and underwent salvage radical prostatectomy was analyzed for clinicopathological and genomic characteristics. Most radiorecurrent tumors were enriched in cribriform morphologies (invasive cribrifom PCa and intraductal carcinoma with cribriform pattern) and demonstrated potentially targetable genomic alterations (defects in DDR genes: TP53, BRCA2, PALB2, ATR etc.). The guest, Dr. Rajal Shah of UTSW, discusses how understanding this phenotypic and genotypic diversity of radiorecurrent PCa is critically important for future management of such patients.

Social interactions play an essential role in the lives of many animals. But how do we disentangle the genetic and non-genetic factors influencing sociality? In this episode, Dr Irene Godoy (Bielefeld University) tells us about her research on sociality in capuchin monkeys.

This episode explores the recent Heredity paper: “Genetic, maternal, and environmental influences on sociality in a pedigreed primate population” https://www.nature.com/articles/s41437-022-00558-6

The Baby Doe Regulations, which regulate the provision of life-sustaining treatment to seriously ill neonates, caused a stir amongst neonatologists when they were first enacted in the 1980s. The fear at the time was that they would restrict their ability to provide optimal care to seriously ill patients by mandating the use of aggressive treatments in all but futile cases, irrespective of a patient's quality of life.

In this episode, we meet Early Career Investigator Katherine Guttman from the Icahn School of Medicine at Mt Sinai, New York. She tells us about her study which aimed to assess contemporary neonatologists' perceptions of the Baby Doe Regulations and to compare them to the views of neonatologists when they were first enacted.

Read the full study here: https://www.nature.com/articles/s41390-022-02105-9

Establishing an efficient and standardized workflow for performing molecular classification on ECs, and reporting both the molecular and histologic findings in an integrative manner, is imperative. Dr. Brooke Howitt discusses with the host her institution’s effort to implement rapid and routine molecular classification on all ECs diagnosed at Stanford.