Sign up to save your podcasts
Or
Share STEMTalks Archive - IHMC | Institute for Human & Machine Cognition
Share to email
Share to Facebook
Share to X
Share to email
Share to Facebook
Share to X
Or
STEMTalks Archive - IHMC | Institute for Human & Machine Cognition
STEMTalks Archive - IHMC | Institute for Human & Machine Cognition episodes
- Episode 190: Judith Curry and the Consequences of Climate Alarmism
Dr. Judith Curry, a climatologist known for her criticism of alarmist, doomsday rhetoric about climate change, returns to STEM-Talk for her second appearance.
Judy most recently was one of five researchers commissioned by the U.S. Department of Energy to draft a Climate Assessment Report summarizing the current state of climate science with a focus on how it relates to the United States. In this interview, Judy summarizes the climate report’s key points, including the finding that that carbon-dioxide induced warming of the planet appears to be less damaging economically than has been commonly believed. The report, which was released this past summer, also argues that aggressive mitigation strategies for carbon dioxide emissions could be more harmful than helpful.
Our interview comes on the heels of the prestigious journal Nature retracting a study that predicted climate change and carbon emissions would cause catastrophic economic damage by the end of the century. Our conversation with Judy also followed an about-face from Microsoft co-founder Bill Gates, who wrote last fall that it’s time to tamp down the alarmist rhetoric that climate change will lead to humanity’s demise.
Curry is president of the Climate Forecast Application Network and host of the blog, Climate Etc, which you can find at JudyCurry.com. Her blog provides a forum for climate researchers, academics and technical experts from other fields as well as citizen scientists to discuss topics related to climate science and science policy.
Her research interests include hurricanes, remote sensing, atmospheric modeling, polar climates, air-sea interactions, climate models, and the use of unmanned aerial vehicles for atmospheric research. She has published more than 100 scientific papers and is the author of “Climate Change and Uncertainty: Rethinking Our Response,” a book that provides a framework for understanding and rethinking the climate-change debate.
Show notes:
[00:03:59] Ken opens the interview explaining that Judy was one of the five authors of a climate assessment report commissioned by the U.S. Department of Energy. Before diving into the key findings of the report and the response it has received, Ken asks Judy to explain how she became one of the five authors.[00:06:21] Ken mentions that critics of the climate working group have accused the authors of being hand-picked skeptics of the effects of climate change. Judy argues that she and her co-authors are scientists determined to get the science right. Ken asks Judy to talk about her co-authors and the working relationship of the group.[00:09:18] Ken asks Judy to talk about how she and her co-authors came to their key finding that the economic impacts of climate change are less severe than typically thought.[00:13:08] Ken asks Judy to provide examples that demonstrate how climate mitigation strategies can be more harmful than helpful.[00:16:08] Ken follows up by asking about the report’s proposal to shift climate science from alarmism to focus more on a better understanding of natural climate variability.[00:18:14] Ken asks Judy what her thoughts are on the next steps that should be taken for a better understanding climate variability.[00:20:06] Ken asks Judy to elaborate on the findings of chapter six of the report regarding global warming and extreme weather events. In particular, Ken asks about the problems with associating specific extreme weather events like hurricanes to climate change, and the issues created by the short historical records we have at our disposal.[00:24:20] Ken asks Judy to talk about chapter nine of the report, which is about the need to focus on reducing vulnerabilities in our infrastructure instead of mitigating carbon emissions.[00:28:43] Ken asks Judy to comment on the accusations that she is a “climate change denier.”[00:31:18] Ken asks Judy to talk about a paper she co-authored with her colleague Dr. Harry DeAngelo titled “A critique of apocalyptic climate narrative.”[00:36:27] Ken brings up Bill Gates’ recent about-face on climate change and the need to pivot away from doomsday views of cataclysmic climate disasters. Ken asks Judy to elaborate on what she has dubbed “climate alarmism fatigue.”[00:39:32] Ken asks Judy to give her thoughts on the issue of sea level rise, particularly in light of the pushback that the DOE report faced on this topic. He also asks her to discuss the recent paper that was released after the DOE report titled “A global perspective on local sea level changes” which proports that there is no statistically significant acceleration of the rate of sea level rise for 98% of the suitable global locations.[00:50:47] Ken points listeners to Judy’s blog, Judycurry.com, where she discusses many of these same issues. Ken goes on to explain that his perspective as well as Judy’s perspective is that climate change has become a scapegoat for many issues. He asks Judy to talk about this phenomenon.[00:55:24] Ken asks Judy what she would like to see in terms of follow-up research to the DOE climate report.[01:00:23] Ken asks Judy about her book “Climate Uncertainty and Risk.”Links:
Judith Curry bio
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
The post Episode 190: Judith Curry and the Consequences of Climate Alarmism appeared first on IHMC | Institute for Human & Machine Cognition.
1 hr 6 min - Episode 189: NASA’s Flawed Plan to Return to the Moon – with Mike Griffin & Lisa Porter
Today’s episode of STEM-Talk features a timely and wide-ranging discussion with Drs. Michael Griffin and Lisa Porter about NASA’s plans to return humans to the Moon, the history of lunar missions, and how China’s advances in space technology pose a serious threat to U.S. national security.
IHMC founder and CEO Emeritus Ken Ford’s interview with Griffin and Porter came 10 days before Griffin appeared before the U.S. House Committee on Science, Space and Technology to give testimony on China’s advancements in space and the risks it poses for the United States.
“We have squandered a 60-year head start on pioneering the space frontier to a nation that, without reason or provocation on our part, has chosen to become our nation’s adversary,” said Griffin in his opening comments to Congress.
In this episode, Griffin and Porter explain why it is critical for the U.S. to return to the Moon before China. They also argue that NASA’s Artemis III mission to return to the lunar surface and establish a permanent base on the Moon is seriously flawed and should be scrapped.
Griffin and Porter are co-founders and co-presidents of LogiQ Inc., a company providing high-end management, scientific and technical consulting services.
Griffin’s background includes roles as the former Undersecretary of Defense for Research and Engineering, the Administrator of NASA, the Space Department Head at the John Hopkins University Applied Physics Laboratory as well as Chairman and CEO of Schafer Corporation.
Porter’s background includes roles as the former Deputy Undersecretary of Defense for Research and Engineering, the founding Director of the Intelligence Advanced Research Projects Activity (IARPA) in the Office of the Director of National Intelligence, and the Associate Administrator for Aeronautics at NASA.
Show notes:
[00:04:44] Ken opens the interview by welcoming Mike back to STEM-Talk, who was a guest on Episodes 23 and 134. He also welcomes Lisa to her first appearance on STEM-Talk and asks her to talk about her decision to major in nuclear engineering at the Massachusetts Institute of Technology.[00:08:50] Ken asks Lisa why she went to Stanford for a Ph.D. in physics.[00:10:43] Ken explains that Lisa was the founding director of the Intelligence Advanced Research Projects Activity (IARPA), a department within the Office of the Director of National Intelligence. Ken asks about some of the challenges the American intelligence community faced that she addressed as director of IARPA.[00:16:15] Ken asks about Lisa’s time working for Mike as Associate Administrator for Aeronautics at NASA, and how she came to accept that role.[00:18:07] Ken explains that when Mike became Undersecretary for Defense for Research and Engineering in 2018, he invited Lisa to become the Deputy Undersecretary for Defense for Research and Engineering. Ken asks Mike why Lisa was ideal for that role.[00:21:07] Ken explains that Mike and Lisa are working together again as co-founders and co-presidents of LogiQ Inc., a company that provides scientific consulting services. Ken asks Mike to give a brief overview of LogiQ’s work.[00:24:44] Ken shifts the discussion to space exploration, noting that he wants to talk about Mike’s 2024 congressional testimony on returning to the Moon, and a paper that he and Lisa published titled “A system architecture for human lunar return.” To begin the discussion, Ken asks why it is so important for us to return to the Moon.[00:29:11] Ken asks Mike and Lisa to explain why it is important for the US to be the first to return to the Moon in the context of China’s ambition to send humans to the Moon and establish a permanent lunar presence.[00:33:24] Ken asks Mike and Lisa if they see the cancellation of the Apollo program as a mistake.[00:35:36] Ken asks Mike and Lisa to give an overview of the Artemis program.[00:41:45] Ken mentions the centrality of the Gateway in the Artemis plan, and the problem with making something that is already hard even harder for no good reason.[00:43:28] Ken mentions his concern that the focus on a Mars-forward approach might impede our success with the current Moon missions.[00:46:40] In Mike and Lisa’s aforementioned paper, they propose a dual-launch lunar landing architecture, which is simpler than the current NASA architecture and presents lower risks to the crew. Ken asks Mike and Lisa to elaborate on this idea.[00:48:41] Ken asks Mike and Lisa what they think are some of the other technical and programmatic problems with the current Artemis plan.[00:52:31] Ken asks Mike and Lisa what NASA’s response has been, as well as the response of others in the human space flight community, to their paper and recommendations for the Artemis mission architecture.[00:54:25] Ken explains that Sean Duffy, the Secretary of Transportation and acting NASA administrator, has opened the door to some additional lander ideas in light of concerns that the two current contractors, Space X and Blue Origin, may not be ready in time for the current Artemis schedule. Ken asks if Lisa and Mike think this is a good idea or if they think it would further complicate matters.[00:59:25] NASA’s current budget is around $24.9 billion dollars, approximately 0.4 percent of total federal spending. Ken notes at a time when China is increasing their investment in their space programs and launching several missions, NASA is facing a proposal to cut its funding by 24 percent to $18.8 billion. Ken asks Mike and Lisa for their thoughts on this.[01:03:13] Ken and Lisa continue Mike’s discussion on the core purpose of NASA beyond science.[01:08:55] Ken and Mike reflect on Ken’s observation that the U.S. is not as serious about space and the Moon as it was during the Apollo years, years that attracted the nation’s best and brightest.[01:09:39] Ken asks Mike and Lisa their thoughts on the way that NASA is contracting more services in the development of Artemis, rather than funding a development program.[01:15:55] Ken wraps up the interview by commenting that he believes listeners will very much enjoy today’s conversation.Links:
Michael Griffin bio
Griffin’s Dec. 4 2025 Congressional testimony
Griffin’s 2024 Congressional testimony
Lida Porter bio
Ken Ford bio
Ken Ford Wikipedia page
Learn more about IHMC
STEM-Talk homepage
The post Episode 189: NASA’s Flawed Plan to Return to the Moon – with Mike Griffin & Lisa Porter appeared first on IHMC | Institute for Human & Machine Cognition.
1 hr 19 min - Episode 188: Marina Walther-Antonio discusses the microbiome’s role in women’s health and cancer
Today we have Dr. Marina Walther-Antonio, a Mayo Clinic researcher who investigates the role of the microbiome in cancer and reproductive health, particularly endometrial and ovarian cancers. According to the World Cancer Research Fund International, endometrial and ovarian cancers are among the top 10 most prevalent cancers in women worldwide, and there are still no standard screenings for early detection.
Marina is an assistant professor in the Department of Surgery and the Mayo Clinic Center for Individualized Medicine Microbiome Program. She has a joint appointment in the department of Obstetrics and Gynecology.
Today we talk to Marina about how she and her colleagues are utilizing the methodologies of environmental microbiology and technologies used in astrobiology to improve our understanding of endometrial and ovarian cancers. Through her investigations into the microbiome, she and her team are developing early detection tests that will enable clinical interventions before certain cancers develop.
Show notes:
[00:03:13] Dawn opens our interview asking Marina about the history of her interest in extraterrestrial life.[00:05:49] Dawn mentions that Marina did her undergraduate studies in Portugal at the University of Aveiro, where she majored in biology. Dawn asks why Marina chose biology as her major.[00:06:39] Ken explains that the undergraduate programs at Aveiro University require students to do a year of research outside the university and asks Marina about her experience with this requirement.[00:08:34] Ken explains that while Marina was conducting her internship at NASA Ames Research Center, there were several projects under way at the astrobiology institute, with the one that Marina was assigned to looking at a Mars analogue site in Oregon’s Warner Valley. Ken asks what kind of work Marina did on this project.[00:10:06] Ken asks Marina why after earning a master’s degree in microbiology from Indiana University, she went to Washington State University to earn a Ph.D. in environmental sciences.[00:13:29] Dawn asks about Marina’s Ph.D. research on microbialites, which are microbial structures that can thrive at the bottom of certain freshwater lakes and other extreme environments.[00:16:02] Dawn explains that just as Marina began researching microbial populations, the Mayo Clinic Center for Individualized Medicine created a microbiome program. Dawn asks Marina about the circumstances that led to her joining Mayo.[00:19:05] Dawn mentions that Dr. Claire Fraser, the director of Maryland’s Institute for Genome Sciences pointed out in Episode 32 of STEM-Talk that there are more microbes on a single person’s hands than there are people on Earth, as well as the fact that our gut is home to more than 100 trillion bacteria. Dawn asks Marina to talk about this microbial side of humanity.[00:21:51] Ken mentions that if listeners are interested in learning more about the microbiome and how it affects human health, they should listen to Episodes 20 and 168 with Dr. Alessio Fasano. Ken asks Marina to give a short overview of the microbiome.[00:25:37] Dawn asks Marina how the focus of her research shifted to the role of the microbiome in cancer and reproductive health.[00:29:00] Dawn explains that endometrial and ovarian cancers are among the top 10 most prevalent cancers in women worldwide; with ovarian cancer being the most common gynecological malignancy and the fifth leading cause of death due to cancer in women in the nation. Dawn goes on to explain that in a 2023 paper Marina investigated the area of microbiome that is associated with ovarian cancer to better understand the microbiome’s potential in early detection. Dawn asks Marina to talk about this study and its findings.[00:35:55] Given the small scale and sample size of her initial study, Ken asks Marina what her ideal follow-up study would look like.[00:38:37] Ken mentions that in 2019 Marina published the results of a study that found that post-menopause is a key factor in the composition of endometrial cancer microbiome. This study also investigated the impact of patient factors on the microbiome, including menopausal status, BMI, and vaginal pH balance. Ken asks Marina to elaborate on the findings.[00:44:13] Dawn notes that there is no standard screening for early detection of ovarian and endometrial cancers despite their prevalence worldwide. Dawn asks Marina about the work she and her colleagues are engaged in in this space.[00:47:17] Dawn explains that prior to Marina’s aforementioned study, vaginal pH had not been associated as a risk factor in endometrial cancer. Dawn goes on to explain that variations in microbial compositions are implicated in a number of gynecologic and obstetric diseases. Marina’s core question was that since the vaginal microbiome is so crucial to women’s health, why then do vaginal microbial profiles vary strikingly from person to person. This question, as Dawn explains, led to a study and 2020 paper titled “Daily Vaginal Microbiota Fluctuations Associated with Natural Hormonal Cycle, Contraceptives, Diet, and Exercise.” Dawn asks Marina to talk about this study.[00:54:23] Ken asks Marina about her finding that exogenous hormones in contraceptives may affect vaginal microbiota.[00:56:42] Dawn asks Marina about future research that will stem from her study.[01:00:29] Dawn asks Marina about her job as director of Mayo’s mentorship and Ph.D. program, and her passion for mentorship.[01:05:24] Given her accomplished and varied career, Ken asks Marina what advice she has for young people beginning their careers in science.[01:10:06] Circling back to Marina’s original interest in the search for extraterrestrial life, Ken explains that among the NASA scientists we’ve had on STEM-Talk there is disagreement on our chances of discovering intelligent life. While our guest Ed Wiler is confident that we will be able to prove the existence of life off earth within the next 20-30 years, Pascal Lee says he doesn’t think it is likely that we will discover intelligent or complex life anytime soon. Ken asks Marina to weigh in on the matter.Links:
Marina Walther-Antonio
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
Dawn Kernagis bio
The post Episode 188: Marina Walther-Antonio discusses the microbiome’s role in women’s health and cancer appeared first on IHMC | Institute for Human & Machine Cognition.
1 hr 20 min - Episode 187: Dawn Kernagis talks about creating permanent subsea human habitats
Today Ken interviews his co-host Dr. Dawn Kernagis about her new position as the Director of Scientific Research for DEEP, a UK startup that is pioneering a new era of ocean exploration.
For listeners unfamiliar with Dawn’s background, she is a NASA-trained NEEMO Aquanaut, a Fellow of the Explorer’s Club Fellow and has been inducted into the Women Divers Hall of Fame. In addition to co-hosting STEM-Talk for the past nine years, Dawn is also a Visiting Research Scientist at IHMC.
Dawn’s research over the years has been focused on protecting the brain and nervous system of people working in extreme environments. Prior to joining IHMC, Dawn completed her Ph.D. and Postdoctoral training at Duke University, where she studied the genetics of decompression sickness and mechanisms of oxygen toxicity in divers.
In today’s interview, Dawn talks about DEEP’s mission to create subsea stations that will allow humans to live and work permanently underwater.
Show notes:
[00:03:20] Ken reminds listeners of Dawn’s first STEM-Talk appearance as a guest on Episode 19 where she conducted the interview from the bottom of the ocean floor while she was a member of NASA’s NEEMO Mission 21.[00:04:13] Ken asks Dawn what she was like as a child.[00:05:48] When Ken asks Dawn what she was like as a child, she talks about how she was an annoying kid because she was always asking people questions like, “Why is the sky blue?”[00:06:49] Dawn talks about the different places she lived during her childhood.[00:07:34] Ken mentions that Dawn was inducted into the Women’s Divers Hall of Fame. He asks her how old she was when she first became interested in diving.[00:10:35] Dawn talks about how she wanted to attend the University of North Carolina after high school but ended up at North Carolina State University and then Duke University.[00:12:18] Ken asks Dawn to elaborate on her decision to change her field of study multiple times throughout her collegiate career. What follows is an interesting conversation about the importance of a person following their passion.[00:14:53] Dawn talks about cave diving and how she and her friends used to do deep dives of six and seven hours at a time. Dawn explains how this led to her obsession with ways to protect people who dive into extreme underwater environments.[00:18:28] Ken asks Dawn how she learned that some people have a genetic predisposition to decompression sickness.[00:21:32] The conversation shifts to Dawn’s Ph.D. journey and how Richard Moon, who was a STEM-Talk guest on episode 26, played a significant role in her development.[00:26:14] Ken and Dawn reminisce on the practice of performing academic research in libraries.[00:28:20] Ken points out that despite Dawn’s extensive experience in human physiology with respect to diving, her doctoral work focused on cancer-related research. He asks her to talk about that seemingly odd combination.[00:34:10] Dawn talks about two papers that emerged from this research. One paper addressed how genes with bimodal expression patterns not only define clinically relevant molecular subtypes of ovarian carcinoma, but also provide ideal targets for translation into the clinical laboratory. The other paper looked at precise microarray-based predictions of tumor behavior in breast cancer patients.[00:39:00] Ken asks Dawn to recount the story of how the two of them met.[00:41:52] Ken asks Dawn to discuss the paper she co-wrote with Dom D’Agostino on mitochondrial health and its relationship to potentially preventing oxygen toxicity during exposure to hyperbaric environments. Dawn goes on to talk about some of her other IHMC-related research.[00:43:22] Ken asks Dawn to discuss her acceptance into the Aquanaut Program and her participation during one of NASA’s NEEMO missions.[00:46:04] Ken asks Dawn to reflect on her time on NEEMO Mission 21, and if there are any key takeaways she can discuss.[00:49:04] Ken asks Dawn to describe saturation diving, the research involved, and the health implications on saturation divers that are not present in other forms of underwater exploration.[00:52:04] The conversation shifts to how Dawn became the Director of Scientific Research for DEEP, a UK startup that aims to “Make Humans Aquatic.”[00:55:02] Ken explains that DEEP is a company that is pioneering a new era of ocean exploration and asks Dawn to give a primer on the importance of better understanding the Earth’s oceans.[00:56:12] Ken mentions DEEP’s mission to expand human subsea habitation through research and innovation. Dawn explains some of the challenges associated with constructing underwater habitats.[00:57:36] Ken asks about DEEP’s goal to create a relatively permanent deep-sea human habitat, analogous to the International Space Station. Called the Sentinel System, the underwater habitat will serve as a place for researchers to live and work.[01:01:23] Ken explains that the Sentinel System will operate at a depth of up to 200 meters, which represents the epipelagic zone, or sunlight zone, which is the deepest point where light penetrates the ocean. To put this in perspective, the average depth of the ocean is 3,688 meters. Ken asks Dawn to talk about how little we actually know about what exists below the 200-meter depth of the epipelagic zone.[01:02:58] Ken mentions that NASA has a long history of using the sea as a loose analogue for space. With renewed interest in human space exploration of the Moon and Mars, Ken asks if the Sentinel System will help in the preparation for deep space missions.[01:05:10] Ken asks Dawn to discuss what other areas of research she is excited to explore once the Sentinel System is fully operational and in the water, including a project that involves IHMC.[01:06:50] Dawn gives an overview of DEEP’s current testing and training facility, which is located in the UK.[01:07:55] Ken asks Dawn to talk about DEEP’s increased presence in the United States and Florida, including a project with the Florida Institute of Oceanography.[01:08:47] Ken asks Dawn about an anonymous billionaire who is funding DEEP.[01:10:06] Ken asks Dawn about her responsibility of establishing DEEP’s first U.S. office in Raleigh, N.C.[01.11.03] Dawn ends the interview talking about how much she loves the work that she does.Links:
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
Dawn Kernagis bio
The post Episode 187: Dawn Kernagis talks about creating permanent subsea human habitats appeared first on IHMC | Institute for Human & Machine Cognition.
1 hr 14 min - Episode 186: Mari Dezawa discusses her discovery of MUSE cells and the role of stem cells in regenerative medicine
Today we have Dr. Mari Dezawa, one of the world’s leaders in stem-cell research and regenerative medicine. Mari is a pioneer in this emerging field and is known worldwide for her discovery of MUSE cells, a unique type of stem cell with exciting clinical potential. MUSE is short for Multilineage-Differentiating Stress-Enduring Cells.
The discovery of the MUSE cell in humans has many biological and medical implications, and the human body may have a greater regenerative potential than we might have ever imagined. In collaboration with major national and international institutions, Mari and her colleagues are promoting research on MUSE cell-based regenerative medicine for diseases without definitive treatments. She and her team are also exploring the differences in regenerative capacity between less and more complex animals from the viewpoint of the stem-cell system.
Mari is a professor and chair of the Division of Stem Cell Biology and Histology at Tohoku University School of Medicine. She has published more than 200 papers and is particularly known for her 2010 paper on the mechanisms of MUSE cells. In 2018, she was appointed a fellow of the U.S. National Academy of Inventors and has been the recipient of numerous awards, including the Japanese Government’s Prize for the Commendation for Science and Technology.
Show notes:
[00:04:10] Ken opens the interview by mentioning that although Mari was born in Japan, her family moved to the U.S. when she was only eight months old. Ken asks if it is true that Mari finds it difficult to answer the question of where her hometown is.[00:05:23] Ken asks Mari how she handled moving so much as a child.[00:05:52] Ken mentions that Mari’s father was a researcher and asks when she became passionate about research and science.[00:06:58] Ken mentions that Mari attended the Chiba University School of Medicine and asks what inspired her to go to medical school.[00:07:19] Ken explains that after Mari earned her medical degree, she attended Chiba University Graduate School of Medicine for her Ph.D. Ken mentions that while Mari was initially a cardiology resident, she later decided to focus on clinical research and became a stem-cell researcher. Ken asks what led her to shift from cardiology to stem-cell research.[00:08:25] Ken explains that Mari is well-known for her research into the role of stem cells in regeneration and functional recovery of nerve and muscle cells. Ken asks how and when she first became interested in stem cells.[00:09:56] Ken asks Mari to give a brief overview of stem cells and their significance.[00:11:18] Ken mentions that Mari remained at Chiba University as a research associate after earning her Ph.D in 1995. She then took a position as an associate professor at Yokohama City University Graduate School of Medicine before accepting a position at Kyoto University Graduate School of Medicine as an associate professor in 2003. Ken explains that while at Kyoto, Mari developed methods to induce bone marrow stromal cells to generate neuro and skeletal muscle cells, which play a crucial role in tissue repair and regeneration and are widely studied for their potential to serve as therapeutic agents. Ken asks Mari to give a quick primer on the crucial role these cells play in tissue repair.[00:13:25] Ken explains that in 2003, a member of Mari’s technical staff at Kyoto asked her whether they should discard some cultured adult rat and human bone marrow mesenchymal stem cells (MSCs) after she had noticed several strange cell clusters. Ken asks Mari to share what happened next and how this set her on the path to the discovery of Multilineage-Differentiating Stress-Enduring Cells.[00:16:03] Ken asks Mari to elaborate on this story and explain how a mistake led to this incredible discovery.[00:20:48] Ken explains that in 2008 Mari became professor and chair of the Department of Stem Cell Biology and Histology at Tohoku University Graduate School of Medicine. Then in 2010 she published a paper on the results of her investigations into MUSE cells. Ken asks about this paper and why it was so significant.[00:25:11] Ken mentions that one of the key characteristics of MUSE cells is their ability to repair organ tissues, and their ability to repair themselves quickly. Ken asks Mari to explain the significance of MUSE cell resilience and self-repair.[00:26:30] Ken asks Mari how MUSE cells are collected.[00:28:26] Ken asks Mari about her 2018 paper that looked at the use of MUSE cells in the treatment of acute myocardial infarction.[00:31:03] Ken explains that stem cells go through cytokine differentiation, a process that can often take several weeks or more to complete. However, Mari uncovered that a simple mechanism could substantially shorten this timeframe, which she reported on in a 2022 paper, titled “Phagocytosing Differentiated Cell-Fragments is a Novel Mechanism for Controlling Somatic Stem Cell Differentiation Within a Short Timeframe.” Ken asks Mari to discuss this paper and its findings[00:33:51] Ken asks Mari if she sees any potential military applications for MUSE cells.[00:35:16] Mari explains what exosomes are and how they might be applied in the context of MUSE cells.[00:36:14] Ken mentions Mari’s report on nasal administration of stem cells titled “Nose-to-Brain Delivery of Human Cells Enhances Structural and Functional Recovery in the Murine Ischemic Stroke Model.” Ken asks Mari to talk about the findings in this paper.[00:37:34] Ken asks Mari about her paper in development on the use of MUSE cells in the treatment of traumatic brain injury and dementia.[00:38:54] Ken brings up the issues with models of Alzheimer’s not tending to reflect the reality of the disease in humans and asks Mari what her plans are for applying her research to human trials in Alzheimer’s.[00:40:21] Ken asks Mari for her thoughts on the use of MSCs and MUSE cells for health span optimization.[00:42:11] Ken explains that in addition to her university work, Mari also works with a company called MUSE Cell Innovations, which is looking to revolutionize regenerative medicine and longevity through advancements in cellular science. For full disclosure, Ken explains that both he and Mari serve on the scientific advisory board of MUSE Cell Innovations. Ken asks Mari to talk about her work there.[00:44:13] Ken mentions that in another interview, Mari talked about how her hobbies were a way of balancing her life and career. However, Mari never explained what those hobbies were, so Ken asks her to elaborate.Links:
Mari Dezawa bio
MUSE Cell Innovations
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
The post Episode 186: Mari Dezawa discusses her discovery of MUSE cells and the role of stem cells in regenerative medicine appeared first on IHMC | Institute for Human & Machine Cognition.
48 min - Episode 185: Andrew Koutnik discusses metabolic health, athletic performance and growing up with type-1 diabetes
Today we have our good friend and colleague Dr. Andrew Koutnik on the show. Andrew is a research scientist who studies the influence of nutrition and metabolism on health, disease and performance. He specializes in Type 1 diabetes and works with a wide range of people to improve their metabolic health and athletic performance.
Andrew is a visiting research scientist at IHMC and has worked with Harvard, Johns Hopkins, NASA, and the Department of Defense to develop evidence-based strategies for overcoming complex health challenges.
He is a graduate of Florida State University and earned his Ph.D. in medical sciences at the University of South Florida, where he worked with another good friend of ours, Dr. Dominic D’Agostino, who has been a previous STEM-Talk guest.
Show notes:
[00:02:50] Dawn welcomes Andrew to the show and asks him about his website, andrewkoutnik.com, the quote on the site’s homepage “Demystifying complex science to help you thrive in your health journey,” and the tagline “Challenging the status quo of metabolic health, human performance, and the management of type1 diabetes.”[00:05:31] Ken asks Andrew how old he was when he first learned he had Type 1 diabetes.[00:08:32] Dawn asks why Andrew believes his Type 1 diabetes is one of his life’s ultimate assets?[00:12:51] Ken mentions that Andrew grew up in Tallahassee and that despite suffering from childhood obesity, he was relatively athletic as a child. Ken asks Andrew to talk about his childhood.[00:14:20] Dawn asks Andrew to talk about the weight-loss journey he underwent as a teenager.[00:17:25] Dawn shifts gears to ask Andrew about how he got into science, mentioning that when he was younger, he never saw himself becoming a scientist.[00:20:19] Dawn asks if it is true that Andrew was the sort of kid who would constantly asked questions.[00:22:11] Dawn asks Andrew if it is true that after enrolling at Tallahassee Community College, it took him a while to decide on his major.[00:22:58] Ken asks Andrew to talk about the impact that his undergraduate anatomy and physiology class and professor had on his journey.[00:24:44] Ken mentions that after graduating from FSU, Andrew went to the University of South Florida where he worked with Dominic D’Agostino, who is both a previous STEM-Talk guest and a current colleague of Andrew’s. Ken asks Andrew how he met Dom.[00:27:46] Dawn asks Andrew how he came to work in Dom’s lab.[00:29:00] Dawn asks Andrew if his wife is still in touch with her former roommate, who connected Andrew and Dom.[00:29:21] Ken asks Andrew to touch on some of the research he did with Dom while he was pursuing his Ph.D.[00:31:49] Dawn shifts gears to talk about Andrew’s work in metabolic health and Type 1 diabetes. Dawn explains that a study published by the University of North Carolina found only 12 percent of Americans were metabolically healthy. Additionally, researchers from the Friedman School of Nutrition Science and Policy at Tufts University found in 2022 that only 6.8 percent of Americans had good cardiometabolic health. Dawn asks Andrew how he works with people who want to improve their metabolic health.[00:34:19] Ken asks Andrew for his thoughts on the sentiment that a ketogenic diet is hard to sustain.[00:36:55] Ken mentions that Andrew was part of a review that looked at carbohydrate restriction for diabetes, which is a practice that had been in use since the 1700s. It fell out of favor once insulin was discovered in the 1920s. Ken goes on to explain that carbohydrate restrictive diets, like the ketogenic diet, have regained popularity for the treatment and management of diabetes, weight-loss and a range of other health issues such as migraines, cancer and depression. Ken asks Andrew to first explain the history of carb-restrictive diets as a treatment of diabetes.[00:39:43] Ken asks Andrew to talk more about the aforementioned 2021 review and its argument in favor of a medical nutrition therapy for diabetes management.[00:47:21] Dawn quotes a passage from the American Diabetes Association website that reads, “Before insulin was discovered in 1921, people with diabetes didn’t live for long. There wasn’t much doctors could do for them. The most effective treatment was to put patients with diabetes on very strict diets with minimal carbohydrate intake. This could buy patients a few extra years but couldn’t save them. Harsh diets, some prescribed as little as 450 calories a day, sometimes caused patients to die of starvation.” Dawn asks Andrew if he feels that this quote discourages the use of carb-restriction and medical nutrition therapy for diabetes management.[00:49:22] Dawn asks Andrew how the treatment of diabetes went from the use of insulin being prescribed along with carbohydrate restriction, to purely pharmacological interventions.[00:50:59] Dawn asks Andrew to talk about the significance of the fact that carbohydrates are the only macronutrient directly digested into glucose, making carbs the main determinant of postprandial glycemia and insulin requirements, which creates a mismatch between insulin kinetics and glucose.[00:55:29] Ken pivots to talk about the work of Jeff Volek at Ohio State University, one of the founders of Virta health, and our guest on STEM-Talk episodes 43, and 149. Ken goes on to explain that Virta offers nutrition-based approaches to losing weight and reversing diabetes. Virta has an impressive track record of success with Type 2 diabetes. The average weight loss for those using Virta’s system is 31 pounds, and enrollees reduced their medications by 63 percent. Ken asks Andrew why these are such impressive achievements.[00:57:07] Dawn asks Andrew about the concerns people have about low carbohydrate diets for diabetes.[01:00:24] Dawn asks, given that total medical costs for diabetes in the US is approaching a billion dollars a day, if Andrew could discuss how research into medical nutrition therapy for diabetes should become a priority.[01:02:44] Dawn pivots to talk about Andrew’s work in optimizing human performance, mentioning that he recently put out an article on Substack titled “Revolutionizing Sports Nutrition: New Insights on Low-Carb vs High-Carb Diets in Strenuous Exercise Performance.” Dawn explains that this article was based on a study Andrew and his colleagues published challenging the conventional thinking that carbohydrates were essential to athletic performance. Dawn asks Andrew to talk about the origins of the conventional wisdom that carb-loading is essential for athletic performance.[01:06:21] Ken asks Andrew to talk about the physiology behind the potential of low-carb diets to improve athletic performance in certain contexts.[01:08:47] Dawn asks Andrew to give an overview of his 2023 paper titled: “Low and High Carbohydrate Isocaloric Diets on Performance Fat Oxidation, Glucose and Cardiometabolic Health in Middle-Aged Males.”[01:13:41] Ken comments on how active, athletic and outwardly healthy-looking people being prediabetic is likely more common than people think.[01:15:35] Ken comments that this incidence of prediabetes in athletes appears to be most common in endurance athletes.[01:17:04] Ken explains that Andrew released a study earlier this year looking at the performance of triathletes who are adapted to very low-carb diets, as well as very high-carb diets. Ken goes on to explain that this study examined the belief that very low-carb diets would impair prolonged performance during strenuous exercise. Ken asks Andrew to explain the design of this study.[01:20:27] Ken explains that the aforementioned study produced three key findings, which he asks Andrew to walk listeners through.[01:23:48] Dawn notes that the ketogenic diet has become more popular in recent years, and that in response one can see numerous “keto-friendly” versions of typically high-carb foods, like breads and ice creams. Dawn asks Andrew what his take is on such products.[01:27:50] Ken asks Andrew if it is true that he has some interesting research findings coming down the pipeline soon.[01:28:36] Dawn wraps up our interview by asking Andrew if it’s true that he taken up jujitsu.Links:
Andrew Koutnik bio
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
Dawn Kernagis bio
The post Episode 185: Andrew Koutnik discusses metabolic health, athletic performance and growing up with type-1 diabetes appeared first on IHMC | Institute for Human & Machine Cognition.
1 hr 32 min - Episode 184: Ken and Dawn answer listener questions on AI, grip strength, ketamine, protein, digital twins, and more!
It’s time for another episode of Ask Me Anything. Dawn and Ken answer listener questions that range from generative AI to whether grip strength is a biomarker for longevity and the potential of ketamine as a treatment for depression. Dawn also gives a brief overview of work she is doing with the deep-sea technology company Deep. As a special treat at the end of today’s episode, Dawn plays a recording of the commencement speech that Ken recently gave at the University of West Florida. As the saying goes, you don’t want to miss it.
Show notes:
[00:02:18] Ken starts off the episode with a listener question about whether Dawn and Ken read print books or digital, the reason being that a listener recently came across an article that claimed digital screens are rewiring our brains.[00:05:32] A listener asks about a paper titled “Grip Strength An Indispensable Biomarker for Older Adults” which claims that the ability to hang from a bar for 60 seconds for men, and 30 seconds for women, indicates that a person is likely to live longer. The paper claims that a decline in grip strength is associated with adverse health consequences, and the listener asks Ken what advice he has for developing and maintaining grip strength.[00:10:20] A listener asks a question inspired by our recent interview with Dr. Frank Butler. The listener asks if Ken has heard about the FDA approved depression therapy, esketamine, which is a derivative of ketamine and is a long-standing therapy for depression.[00:12:37] A listener asks Ken about a 2023 paper in the journal Age and Aging titled “Higher Dietary Protein Intake is Associated with Sarcopenia in Older British Twins”[00:16:13] A listener asks Ken about “Whisper,” which is a transcription product from OpenAI. The listener explains that OpenAI disclaims that Whisper should not be used in high-risk domains. However, according to a story by the Associated Press titled “Researchers Say an AI Powered Transcription Tool Used in Hospitals Invents Things No One Ever Said,” medical centers have already begun to use the tool to transcribe physician consultations. The listener explains that, according to the article, the use of Whisper in these contexts has led to numerous ‘hallucinations’ from the AI tool and the listener asks Ken what his thoughts are on how tools like Whisper should be integrated into various industries.[00:20:21] A listener asks for Ken’s thoughts on a series of articles by Kevin Roose in The New York Times claiming that there is no reason to learn how to code and program because very soon AI will take over all coding. Mr. Roose also asserts that the time is soon approaching when we need to have discussions on what rights to grant sentient AI.[00:21:57] A listener asks Ken if he concurs with a report from the National Academy of Medicine titled “Generative Artificial Intelligence in Health and Medicine – Opportunities and Responsibilities for Transformative Innovation,” which notes that large language models (LLMs) hold huge promise for patient care and healthcare system workflows, as well as risks. The listener asks if Ken agrees with the report’s claims that two areas in which we could see near term applications of LLMs are patient education and synthesis of information of electronic medical records.[00:23:35] As a follow up question, Ken is asked about the aforementioned report’s discussion of the “digital twin” concept. A digital twin is a computational representation of a patient or disease that could be used to speed up virtual experiments or subgroup analysis of investigational agents that carry risk for real patients.[00:26:26] A listener asks for Ken’s thoughts on a paper published in the journal of Nutrition Health and Aging titled “Effects of Vitamin D3 Omega 3 Fatty Acids and a Simple Home Exercise Program on Change in Physical Activity Among Generally Healthy and Active Older Adults.” The paper claims that among generally healthy, active and vitamin D3 replete individuals 73 and older, that Vitamin D supplementation had a detrimental effect on physical function and activity.[00:28:32] A listener asks Ken and Dawn what their take is on the term “settled science” and if it is ever appropriate to call some science “settled.”[00:30:06] A listener asks both Ken and Dawn whether they have a favorite healthy snack.[00:31:31] A listener asks Ken about his blood flow restriction training and what devices he uses for these workouts.[00:32:29] A listener asks about a new sub-sea technology company called Deep, which Dawn works with.[00:34:21] Dawn wraps up the episode mentioning that a little birdie told her that Ken recently gave a good commencement address to the graduating class of 2025 at the University of West Florida. Dawn then plays the audio from Ken’s speech.Links:
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
Dawn Kernagis bio
The post Episode 184: Ken and Dawn answer listener questions on AI, grip strength, ketamine, protein, digital twins, and more! appeared first on IHMC | Institute for Human & Machine Cognition.
45 min - Episode 183: Michael Schmidt on the challenges of building a space-faring civilization
Today we have the second installment of our interview with Dr. Michael A. Schmidt, the founder, CEO, and Chief Scientific Officer of Sovaris Aerospace, a company focused on assessments and solutions applied to humans in space and extreme environments on Earth.
In today’s interview, we talk to Michael about NASA’s plans to send humans to Mars and build permanent colonies on the Moon and Mars. We also talk to Michael about his recent book, “Building a Space-Faring Civilization,” which addresses the challenges of civilian spaceflight and the construction of space settlements.
In part one of our interview, Episode 182, we talked with Michael about his pioneering work in the field of precision medicine and how he has used it to improve the cognitive and physical performance of astronauts as well as NBA, NFL players and Special Operations forces.
In addition to his work with Sovaris, Michael also is a professor of aerospace medicine at the University of Central Florida College of Medicine, one of the few programs in the U.S. that offers a medical residency in aerospace medicine.
Show notes:
[00:03:00] Dawn picks up our interview from where we left off in part one, discussing the Human Research Program for Civilian Spaceflight. She goes on to mention that Chris Mason at Cornell University has a biobank of 1,500 samples across 22 astronauts and seven missions, and that these samples will lead to deeper insights on the effects of spaceflight on humans. Dawn switches gears to ask Michael about the cognitive and physical challenges of spaceflight over long duration missions.[00:13:03] Following up on the cognitive challenges of long duration spaceflight, Ken mentions that the hippocampus, the primary memory center of the brain, has a relatively low radiation threshold compared to other tissues in the brain. Ken asks Michael to touch on the vulnerability of specialized brain tissues to radiation, particularly in the context of a long duration spaceflight to Mars.[00:21:53] Ken mentions that it is understood that the APOE4/4 genotype is associated with impaired cognitive performance under certain circumstances and an elevated risk of dementia. While it is currently unknown whether APOE4/4 has any correlation of increased risk associated with cognitive impact resultant from environmental exposure due to spaceflight, Ken highlights the concern with sending APOE4/4-positive astronauts on long duration spaceflights without knowing the risks.[00:29:26] Ken notes the worsened cognitive impacts resultant from medical radiation, and while therapeutic radiation is different than radiation experienced by astronauts, these results give some indication of the effects astronauts might experience.[00:33:27] Dawn mentions that we recently had planetary scientist and director of NASA’s Haughton-Mars project, Pascal Lee, on the podcast, who explained his view that since there are so many engineering and biological challenges with going to Mars, we should take a more measured approach to a Mars mission, perhaps even beginning with a roundtrip to Mars rather than landing on our first visit. Dawn asks Michael what his thoughts are on this approach.[00:37:29] Ken shifts the discussion to the subject of one of Mars’ moons, Phobos, and its potential role in a Mars mission.[00:40:30] Dawn pivots to talk about Michael’s Book “Building a Space-Faring Civilization: Advancing the Renaissance of Science, Medicine and Human Performance in Civilian Spaceflight.” Dawn asks Michael to talk about the chapter concerning the question of space radiation from the standpoint of precision medicine.[00:55:12] Dawn asks Michael to talk about the lack of appreciation people have for the fact that a Mars mission would be the most dangerous thing we’ve ever done.[00:59:06] Ken mentions that Michael has worked with a lot of organizations, including Space X, which has a program, the Space X Mars Colonization Program, dedicated to the establishment of a permanent colony on Mars. Space X’s founder Elon Musk recently made a statement to his employees that in 20 years he anticipates having a million people colonizing Mars. Ken asks Michael to elaborate on the difficulties entailed with not just a sortie mission to Mars but attempting to establish a permanent presence there.[01:03:38] Ken notes the effect that lofty ideas about colonizing Mars have on people is a lack of appreciation for the tremendous difficulty of the task before us. Ken notes that when we do make it to Mars, the appreciation for the monumental accomplishment that it will be could be seen as inadequate by a public fed ideas about colonizing Mars in the next 20 years.[01:11:08] Dawn notes that one of the most underappreciated, yet critical, components of long duration spaceflight is the psychology of team dynamics. Considering the isolation and close quarters environment of a spacecraft, how teams interact and how they will mediate conflict is an important problem to consider.[01:13:59] Dawn shifts gears to talk about Michael’s co-editor for his book, Dr. Marianne Legato, an emeritus professor of clinical medicine and Columbia University, and a practicing internal medicine specialist in New York City known for her sex-specific medicine and research. Dawn asks Michael how he and Marianne met.[01:16:33] Dawn asks Michael, with respect to his and Marianne’s work on sex and gender differences, how the challenges that men and women face in spaceflight differ.[01:23:31] Dawn comments on Michael’s fascinating career and asks him if it is what he envisioned for himself when he was in college.[01:27:05] Ken wraps up our interview by asking Michael what advice he has for students and young researchers just starting their careers.Links:
Michael Schmidt bio
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
Dawn Kernagis bio
The post Episode 183: Michael Schmidt on the challenges of building a space-faring civilization appeared first on IHMC | Institute for Human & Machine Cognition.
1 hr 35 min - Episode 182: Michael Schmidt on what precision medicine means to human spaceflight
Today we have Dr. Michael A. Schmidt, the founder, CEO, and Chief Scientific Officer of Sovaris Aerospace, a company focused on assessments and solutions applied to humans in space and extreme environments on Earth. Michael is also a professor of aerospace medicine at the University of Central Florida College of Medicine, one of the few programs in the U.S. that offers a medical residency in aerospace medicine.
Michael is known for his work pioneering the field of precision medicine. He uses molecular analytics, coupled with physiologic and behavioral assessments, to facilitate human performance and resilience on Earth as well as in the extreme environment of space.
His work covers a spectrum from NASA, the NFL, the NBA, U.S. Olympic teams, Nike, SpaceX, Axiom Space, NASCAR, Special Operations, the Naval Submarine Medical Research Lab, the Mayo Clinic, and others.
We had a long and fascinating conversation with Michael and decided to break the interview into two parts. This episode focuses on Michael’s background and the cognitive and physical challenges astronauts experience in spaceflight. We also dive into the many ways that precision medicine is facilitating human performance and resilience here on Earth. In part two of our conversation, Michael talks about his work with NASA and SpaceX on the challenges of civilian spaceflight and the future of Mars exploration, including the construction of permanent colonies on the Moon and Mars. You won’t want to miss that conversation.
Show notes:
[00:03:59] Dawn opens our interview mentioning that Michael grew up in Minnesota in a small farming community, asking if it’s true that he sometimes had to do chores in 20- to 30-degree weather.[00:06:50] Dawn asks if it is true that Michael fell in love with science at a young age, even building telescopes at the age of 11.[00:08:00] Dawn asks Michael what it was that led him to become so fascinated with space specifically.[00:08:58] Dawn asks if Michael ever thought about becoming an astronaut.[00:10:09] Ken asks if it is true that Michael was a big reader as a child.[00:11:21] Dawn asks Michael to talk about his childhood athletic interests.[00:11:55] Dawn asks how it was that a high school quarterback from a small town in Minnesota ended up at university in the United Kingdom.[00:13:38] Ken asks Michael what years he worked at NASA Ames Research Center.[00:14:51] Ken mentions that when Michael was at NASA Ames, he did work collecting molecular and physiologic assessments of humans using NASA’s 20-G centrifuge. Ken asks Michael to talk about the centrifuge and how he used it in his studies of hypergravity.[00:17:49] Ken comments on the fact that pieces of equipment like NASA’s 20-G centrifuge are a precious scientific resource, and when they cease functioning, unfortunately, they are unlikely to be replaced.[00:19:40] Ken and Michael discuss the fact that microgravity, despite being one of the most pressing effects on astronaut health, is the one of the least addressed problems in human spaceflight.[00:21:48] Ken explains that Michael is the founder, CEO and Chief Scientific Officer of a company called Sovaris Aerospace, which is focused on assessments and solutions applied to humans in space and extreme environments on Earth. Ken asks Michael where the idea came from to found this company.[00:24:35] Dawn explains that since the human genome was first sequenced, there has been an acceleration of genome-based technologies that have made it possible to consider a person’s genetic makeup, both in healthcare and optimizing performance. Dawn asks Michael to talk about the work he does applying genomics to human spaceflight.[00:28:52] Dawn asks about Michael’s direction of the molecular profiling and precision medicine efforts for the Golden State Warriors during their record-breaking 73-9 season[00:32:57] Dawn mentions that Michael published a review in the journal Metabolomics in 2013 that looked at the use of omics-based analyses and their potential to enhance astronaut safety and performance. Dawn goes on to say that omics allows us to identify differences in humans responsible for different responses to extreme conditions. Dawn asks Michael to talk about this review and what he learned in terms of the risk profile of individual astronauts and how personalized medicine could mitigate some of the risks.[00:42:01] Ken circles back to the heterogeneity of responses to exercise in space, a phenomenon that is seen on Earth as well. Ken notes that while large populations of astronauts don’t yet exist to be studied, large populations and their response to exercise can be studied on Earth, such as Marcas Bamman’s current NIH-funded multicenter exercise study with aging populations here at IHMC. Here Michael talks about his work creating “digital twins” of astronauts to model exposure to extreme environments on personalized digital models of astronauts.[00:46:04] Ken mentions that the difference between digital twin models in engineering and digital twins used in biomedicine is that engineered systems are nearly fully understood and can therefore be modeled with great accuracy and completeness, while there is much more unknown in biological systems.[00:48:15] Ken asks Michael, given all the confounds and environmental stressors in spaceflight, how confident can we be that omics analyses performed on Earth will provide useful insights about performance in space.[00:54:13] Dawn pivots to discuss Michael’s work as president of the Human Research Program for Civilian Space Flight, the purpose of which is to address the widespread needs that civilians will face as space travelers.[01:01:03] Ken shifts gears to ask Michael to talk about the specific cognitive and physical challenges that humans will face in long duration spaceflight, such as a flight to Mars.[01:10:05] Ken mentions that APOE4/4 positive patients see increased risk of cognitive decline from therapeutic radiation on Earth. Ken notes that while therapeutic radiation is different from the radiation experienced by astronauts, this still poses worrying prospects for APOE4/4 positive astronauts.[01:11:28] Ken and Michael discuss the importance of developing both biological and engineering countermeasures to hazardous exposure to astronauts in space.Links:
Michael Schmidt bio
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
Dawn Kernagis bio
The post Episode 182: Michael Schmidt on what precision medicine means to human spaceflight appeared first on IHMC | Institute for Human & Machine Cognition.
1 hr 16 min - Episode 181: Ken Forbus talks about AI and his development of the Structure Mapping Engine
Our guest today is Dr. Ken Forbus, the Walter P. Murphy Professor of Computer Science and a Professor of Education at Northwestern University.
Joining Dr. Ken Ford to co-host today’s interview is Dr. James Allen, who was IHMC’s associate director until he retired a few years ago. James is a founding fellow of the American Association for Artificial Intelligence and a perfect fit for today’s discussion with Dr. Forbus, who, like James, is an AI pioneer. Back in 2022, James was named a fellow by the Association for Computational Linguistics, an organization that studies computational language processing, another field he helped pioneer.
Dr. Forbus also is a Fellow of the Association for the Advancement of Artificial Intelligence and was the inaugural winner of the Herbet A. Simon Prize for Advances in Cognitive Systems. He is well-known for his development of the Structure Mapping Engine. In artificial intelligence and cognitive science, the Structure Mapping Engine is a computer simulation of analogy and similarity comparisons that helped pave the way for computers to reason more like humans.
Show Notes:
[00:03:07] Ken opens the interview with Dr. Forbus by asking if it is true that he had an unusual hobby for a nerdy kid growing up.[00:04:18] James mentions that Dr. Forbus’ family moved often when he was younger and asks how that affected him.[00:05:18] Ken mentions that when Dr. Forbus was in high school, he filled his free time reading about psychology and cognition before eventually coming across some articles on AI. Ken asks Dr. Forbus to talk about this experience and what happened next.[00:07:49] James asks Dr. Forbus if he remembers the first computer he owned.[00:09:17] Ken asks Dr. Forbus if there was anything, other than its reputation, that led him to attend MIT.[00:10:09] James mentions that for the past few decades, Dr. Forbus has been working on developing “human like” AI systems. While much of AI research and development has been focused on meeting the standard of the Turing test, James asks Dr. Forbus why he is not a fan of the Turing test.[00:12:24] Ken mentions that Dr. Forbus received his Ph.D. from MIT in 1984, the same year that Apple released the first Macintosh, which was rolled out with a famous Super Bowl ad. This computer was the first successful mouse driven personal computer with a graphical interface. Ken asks Dr. Forbus what he remembers about that ad, and what his reaction to it was at the time.[00:13:22] James mentions that 1984 was also the year that Dr. Forbus made his first splash in the AI world with his paper on qualitative process theory. James goes on to explain that at the time, qualitative reasoning regarding quantities was a major problem for AI. In his paper, Dr. Forbus proposed qualitative process theory as a representational framework for common sense physical reasoning, arguing that understanding common sense physical reasoning first required understanding of processes and their effects and limits. James asks Dr. Forbus to give an overview of this paper and its significance.[00:18:10] Ken asks Dr. Forbus how it was that he ended up marrying one of his collaborators on the Structure Mapping Engine project, Dedre Gentner.[00:19:14] James explains that Dedre’s Structure Mapping Theory explains how people understand and reason about relationships between different situations, which is central to human cognition. James asks Dr. Forbus how Dedre’s theory was foundational for the Structure Mapping Engine (SME).[00:25:19] Ken mentions how SME has gone through a number of changes and improvements over the years, as documented in Dr. Forbus’ 2016 paper “Extending SME to handle large scale cognitive modeling.” Ken asks, as a cognitive model, what evidence Dr. Forbus has used to argue for the psychological and cognitive plausibility of SME.[00:30:00] Ken explains that many AI systems rely on deep learning, which is a subset of machine learning, using multi-layered artificial neural networks to automatically learn and extrapolate data. Ken goes on to say that Dr. Forbus has pointed out that both people and SME are able to learn successfully with far less data than deep learning requires. Ken asks Dr. Forbus to expand on this.[00:35:21] James mentions that Dr. Forbus has been working a lot over the past decade on companion cognitive architectures, which aim to reach human level AI, by creating software social organisms, which are systems that interact with people using natural modalities. Dr. Forbus elaborated on this in a 2016 paper titled “Software social organisms: Implications for measuring AI progress” where he argued that achieving human level AI is equivalent to learning how to create sufficiently smart software social organisms. James asks Dr. Forbus to briefly describe this concept.[00:44:18] James mentions that Dr. Forbus’ goal with this system is to create systems that can interact with people as apprentices or collaborators rather than just tools. In Dr. Forbus’ paper “Analogy and Qualitative Representations in the Companion Cognitive Architecture ,” he presents two hypotheses on how to create such systems. Starting with the first, James asks Dr. Forbus to elaborate on his hypothesis regarding analogical reasoning and learning, incorporating retrieval and generalization as well as SME capability for analogical matching.[00:48:38] Ken asks Dr. Forbus to elaborate on the second hypothesis, qualitative representations.[00:51:11] James asks if it is correct that Dr. Forbus’ key takeaway in this paper was that the models of structure mapping were particularly robust.[00:52:00] Ken pivots to discuss Dr. Forbus’ book “Qualitative Representations: How People Reason and Learn About the Continuous World” in which Dr. Forbus proposes that qualitative representations, which are symbolic representations that carve continuous phenomena into meaningful units, hold the key to one of the deepest mysteries of cognitive science and are central to human cognition. Ken asks Dr. Forbus to talk about his book and its key points.[00:57:32] James explains that Dr. Forbus followed up his book with a review in Science Direct, exploring how visual reasoning tasks involving comparison provide insights into how people make similarity and difference judgements. James goes on to mention that Dr. Forbus and his colleague Andrew Lovett summarized evidence that the same structure mapping comparison processes that seem to be used elsewhere in cognition can be used to model comparison in human visual reasoning tasks, and this relies on qualitative visual relationships computed using CogSketch, a model of high-level human vision. James asks Dr. Forbus to talk about these findings.[00:59:22] James mentions that Dr. Forbus and his colleagues published a paper about the importance of sketch worksheets in STEM classrooms. They argue that sketching can be a valuable tool for science, but it is currently underutilized. Dr. Forbus and his colleagues recommend sketch worksheets that use AI technology to give students immediate feedback and give instructors assistance in grading. James asks Dr. Forbus to explain what sketch worksheets are and how they can be helpful.[01:01:06] Ken asks Dr. Forbus to give some examples of homework that have been assigned with sketch worksheets.[01:02:34] Ken brings up another one of Dr. Forbus’ papers, which focused on the issues of adversarial attacks on ethical AI systems. The paper investigated moral axioms and the use of deontic logic in a norm learning framework. They found that adding axiomatic moral prohibitions and deontic inference rules to a norm learning model will make it less vulnerable to adversarial attacks. Ken asks Dr. Forbus to talk more about this.[01:07:09] James asks Dr. Forbus what his thoughts are on the idea that AI will soon begin to replace humans.[01:19:52] James explains that the impressive performance of deep learning systems, particularly LLM’s like ChatGPT has simultaneously made it harder for researchers to engage in building cognitively based systems. James asks Dr. Forbus for his thoughts on how we might lay the groundwork for continuing the important work in cognitively based systems.[01:22:54] Ken closes our interview by asking Dr. Forbus if he is thinking about retirement anytime soon.Links:
Learn more about IHMC
STEM-Talk homepage
Ken Ford bio
Ken Ford Wikipedia page
Dawn Kernagis bio
Ken Forbus bio
The post Episode 181: Ken Forbus talks about AI and his development of the Structure Mapping Engine appeared first on IHMC | Institute for Human & Machine Cognition.
1 hr 26 min