In this episode of Everyday Health Stories, Dr. Kota Reddy joins Anna to explore the surprising reasons why weight loss medications like Ozempic and Mounjaro work for some but not for others. Dr. Reddy explains the roles of insulin and leptin resistance, uncovering how these often-overlooked factors can block the effectiveness of weight loss treatments. Listeners gain practical advice on identifying signs of resistance and learn how addressing sleep apnea, managing stress, and reducing sugar intake can dramatically improve medication outcomes. Dr. Reddy emphasizes that understanding these root causes can make all the difference in a successful weight loss journey.