Since the elucidation of the DNA structure by James Watson and Francis Crick in 1951, the importance of understanding the three-dimensional structure of biomolecules has become obvious. Over the last few decades scientists have resolved the structure of thousands of complex biomolecules enabling incredible innovations in drug design, biological and medical sciences. X-Ray crystallography has been the key technique, but in recent years Nuclear Magnetic Resonance (NMR) has emerged as an additional, complementary approach. Dr. Loren Andreas explains to us how NMR has grown to be the technology of choice as it has expanded its field of application from liquid solutions to condensed systems. The discussion is a surprising discovery of how progress in engineering and instrument design has completely changed the landscape in structural biology. Modern NMR allows scientists to study molecules in complex systems, simulating more closely their natural environment, including interaction between them. This episode offers an exciting glimpse of the future, through a few examples from today’s science.

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