With linear disposition pharmacokinetic models (distribution, metabolism and excretion first order) it is possible to add concentration from various doses together to get the total drug concentration. Various types of doses can be included at various times.

Superposition Principle

Pharmacokinetic and Biopharmaceutics from the University of Oklahoma College of Pharmacy - PDF files of course material, Audio AND Video tutorials
PHAR 7633 - Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.

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Pharmacokinetic and Biopharmaceutics from the University of Oklahoma College of Pharmacy - PDF files of course material, Audio AND Video tutorials PHAR 7633 - Description and quantitation of factors affecting the absorption, distribution, and metabolism, and excretion of drugs. Development of appropriate dosage regimens and graphical analysis of drug concentration data sets. Bioequivalence and drug product testing. Drug analysis in biological matrix.

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Superposition Principle

Superposition Principle