Connor Mcspadden and Keith Carey are a hilarious duo. And it all might have been different if Connor had gone into the sciences instead of stand up at the age of 16. Coming from their podcast Mean Boys and their appearances on Comedy Central's Roast Battle, they stop by to "discuss" HIV farming bacteria, heat death of the universe, gradient driven evolution, and testing estimating how many boobs fit in a race car.

Technology writer Gina Hall comes to West Hollywood to explain how her recent article managed to get Mark Zuckerberg and Elon Musk into an all out Twitter war over the future of artificial intelligence. She and Kevin tell Griff about the rich and proud history of Caltech prank culture and what it is like covering news out of the world's most powerful start up community.

Neuroscientist and comedian Ori Amir explains to Kevin and Griff how he used fMRI brain scans of comedians to study and analyse the neurogenesis of humor and clever insight in the human brain.

Jimmy, Griff, Kevin, and comedian Ryan Demarest, a double finalist of Kevin and Bean’s April Foolishness critique Nye’s new show, the identity politics of Saturn’s moon-ring spectrum, and party crashing the Space Shuttle.

Dr. Kristjan Stone joins us to chat about space probes. space logos and all things otherwise spacey. Jimmy gives us the lowdown on his bigger role on Season 4 of Silicon Valley.

Biologist and comedian Forest Shaw talks styrofoam cups in space, climate change, reptile stunt pay, science budgets, and juice box conspiracy theories. Jimmy wraps another season of Silicon Valley. Kevin proposes a possible method for solar systems to spread life.

Dr. Sean Carey and his team discovered seven brand new earth-like planets orbiting another tiny star just a stone hops away from our sun! Matthew, Jimmy, Kevin and Griff ask him about the possibility of life there and the probability of humans traveling there.

Show favorite and Planet Nine discoverer Konstantin Batygin and Astrophysicist Fred Adams join the entire SYJ gang including Patriots Day star Jimmy O Yang and the newly appointed co-host Matthew Broussard to discuss just how lose the sun's grip on the solar system really is.

Roboticist Dr. Heather Knight swings down from Stanford for the New Year and her annual Robot Film Festival. Heather shares her work with Griff, Kevin and guest co-host comedian Sarah Keller, on creating a robot stand up comedian.

Applied Mathematician turned comedian, actor, and cartoonist Matthew Broussard talks to Kevin and Griff about his recent career successes (like his first Comedy Central spacial) making them kinda jealous. The also touch on lighter topics like the true nature of space and time, quantum entanglement, and Mathematical theorems that have awkward names that make people uncomfortable.