A stop motion video that went viral in the 90s led to the making of the South Park pilot, beginning yet another long-running animated TV comedy that continues to resonate through the decades.

We're going down to Texas to discuss the pilot of King of the Hill which cemented the success of Mike Judge as a comedic storyteller, I tell you what.

We're kicking off a summer of animated sitcoms by discussing the pilot of The Simpsons! Although not originally intended to be the series premiere, the season one Christmas episode began the longest-running comedy in TV history.

We're wrapping up our medical show pilot series with the premiere of The Good Doctor which invited viewers to see the world through the eyes of its autistic main character.

The pilot of The Mindy Project kickstarted Mindy Kaling's rise to a lead writer and TV producer, building off of her success in The Office to establish her own brand of comedy.

Nurse Jackie's first episode injected an antihero into the medical genre and saw the return of Edie Falco to premium network television.

Grey's Anatomy has been a top-rated show and cultural touchstone since premiering in 2005, resulting in its stars and creator Shonda Rhimes becoming household names.

The FX original Nip/Tuck got off to a fast start with its graphic depiction of plastic surgery and a dense, crime-driven plot.

The pilot of Scrubs introduced a style of humor new to the medical genre, balancing heartfelt stories with slapstick comedy and surreal daydreams.