Nicholas Goldner, PhD, is the CEO and co-founder of resistanceBio, where he leads a mission to outsmart cancer by developing innovative therapies targeting treatment resistance mechanisms. He also serves as a venture partner at Pioneer Fund, actively investing in and supporting early-stage founders solving complex problems with science and technology. With a distinguished academic background, including a PhD in Molecular Cell Biology from Washington University in St. Louis, Nicholas combines scientific expertise with entrepreneurial prowess to create impactful solutions for pressing health challenges.

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Over 321 books from 170 plus interviews over 5 years

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https://youtu.be/h-xQBKlgAoQ

PODCAST INFO:

The Learning With Lowell show is a series for the everyday mammal. In this show we’ll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn’t normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups.

LINKS

Spotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRH

RSS: https://www.learningwithlowell.com/feed/podcast/

Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q

Youtube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfA

Website: https://www.learningwithlowell.com/

Nicholas Goldner links

https://www.linkedin.com/in/nicholas-goldner/

https://www.resistance.bio/

Timestamps

00:00 Introducing Nicholas Goldner and ResistanceBIO

00:30 Saving 600,000 people a year

01:30 ENCER models for pharma 

04:30 Importance of ResistanceBIO to understanding cancer

05:40 Why cancer comes back / resistance mechanisms

07:30 Cure vs treatment 

09:00 Cancer is natural  

10:30 Full ResistanceBIO platform explained 

14:55 Last 3 years of development 

17:30 Knowing they were on the right path, supportive data,  and deeper understanding

24:50 Business incentive and business model explained 

28:30 Hiding cure for cancer myth

31:00 Diagnostic potential

32:30 Last things pharma is looking for from them

34:30 Confidence in targeting/ therapy

35:45 Platform helping understand why failures happen

38:00 Adding 10,000,000,000 years of life

40:20 Nerding out and coffee 

41:20 Headache caffeine 

41:55 Looking to hire - cell culture scientist work

43:55 Key experiences that will translate into the role

45:55 Cellular agriculture / specialization

48:10 How do ENCER models differ from CRISPR, Organoids, and Animal models in terms of simulating resistance (FanQ)

54:30 What is left to do / what he needs help with

58:45 Immunotherapy and landscape change for cancer treatment and cure

01:01:40 Next 5 years and Lowell offers to chase Nick

01:03:50 Handling burnout and mental health 

01:07:40 Art / being creative / painting

01:12:05 What books is he reading and what he recommends

01:14:23 Foundation apple tv show

01:15:10 Retirement for Nick

01:16:55 Police brutality episode https://www.youtube.com/watch?v=WgKBIb6Zb5c

01:17:40 Non resistance life