Taylor & Francis

In this episode, we discuss recombinant proteins: what are they and what are they used for?

BioTechniques Editor Tristan Free speaks to Amy Sheng, Technical Account Manager at Sino Biological, who explains the history of recombinant proteins and how protein modeling techniques such as AlphaFold are changing their development.

Find out how monoclonal antibodies have been used through the COVID-19 pandemic and how we may overcome challenges in production, upscaling and more in this episode of Talking Techniques. 

Contents:Introduction 00:00-01:26What are recombinant proteins and what are they used for? 01:26 – 02:42How were they first developed? 02:42 – 03:50Since initial development has recombinant antibody development progressed today? 03:50 – 05:57What are the advantages of utilizing the more traditional mouse monoclonal antibodies? 05:57 – 07:11Are recombinant antibodies used in more specialist applications and are they more likely to be used in therapeutics? 07:11 – 09:47How have AI systems like AlphaFold impacted the development of recombinant antibodies? 09:47 – 12:07How has antibody production changed and what’s next? 12:07 – End 

In this Tech Blast episode, we discuss generating, standardizing and sharing microbiome data with Raul Cano, Chief Scientific Officer at The BioCollective. Raul provides a brief overview of the reproducibility crisis and explores how the use of standards and databases can address the challenges it poses.

Get Raul’s insight into the field and discover the steps that can be taken to make microbiome research accessible and reproducible.

Contents:

Introduction: 00:00–00:40

Overview of the reproducibility crisis: 00:40–02:25

The importance of standards for microbiome data: 02:25–05:05

Sharing microbiome data: 05:05–07:10

Comparing microbiome databases: 07:10–08:20

The significance of metadata: 08:20–08:50

How databases can enhance the use of standards: 08:50–10:05

Databases help standardize microbiome research: 10:05–10:45

Benefits of sharing data: 10:45–11:40

In this '3D and tea' interview, we speak to Dolores Serrano and Katerina Lalatsa all about the potential of utilizing 3D printing in cancer studies.

NCTalks with Jan Hillert: pregnancy outcomes in MS by Taylor & Francis Group

Flow cytometry for CGT assay development: an interview with Richard Cuthbert by Taylor & Francis Group

In this podcast, Andrew Hall (Labcorp, UK) discusses the evolution of large molecule bioanalysis workflow automation as well as the present challenges facing the industry.

Bioanalytical assays for gene therapy programs: an interview with Catherine Vrentas by Taylor & Francis Group

In this episode, supported by Zymo Research, we discuss the epigenetic clock: what is it? How are researchers using it and what are some of the key tools available to study it?

Elucidating the link between epigenetics and aging is Keith Booher, Director of Services at Zymo research including aging and epigenetics research services. Keith reveals how our behaviors and environment, such as diet, exercise and air quality, can impact our epigenetics and the impact that the epigenetic clock has played in the development of new therapeutics.

Find out how you can reverse your biological age, the implications of aging populations the latest developments in epigenetic research and more in this episode of Talking Techniques. 

Contents: Introduction: 00:00-02:15The issue with population aging: 02:15-03:30Introducing epigenetics:  03:30-04:20The link between epigenetics and aging: 04:20-05:50The impact of exercise on epigenetics: 05:50-06:40The epigenetic clock: 06:40-08:00What can the epigenetic clock tell you about someone’s health: 08:00-10:05Can you reverse the epigenetic clock? 10:05-12:00The latest experiments in epigenetics and aging research: 12:00-14:10Finetuning exercise using the epigenetic clock: 14:10-15:30Challenges in epigenetics and aging research: 15:30-17:00Key technologies in epigenetics and aging research: 17:00-18:05Where are the main developments coming from? 18:05-19:30Aging and lobsters: 19:30-20:45How will the field develop in the next 5 years? 20:45-22:00What would you ask for to improve your understanding of the epigenetic clock? 22:00-23:00The most exciting aspects of aging intervention: 23:00-24:00

ddPCR for CGT quality control: a podcast with Mark White by Taylor & Francis Group

In this podcast Barry Jones (Director, LC–MS Biologics and Biomarkers at Q² Solutions) and Adriane Spytko (Manager, LC–MS Biologics at Q² Solutions; both NY, USA) discuss hybrid assays using both LBA and LC−MS techniques. They share their thoughts on bottom-up LC−MS methods and the concern about detecting analyte that is not intact as well as future projects that bridge LC−MS and LBA.