The rapidly evolving field of protein design is revealing solutions to some of the world’s greatest problems, whether it's blocking a virus, breaking down a pollutant or creating brand-new materials. In conversation with TED’s Whitney Pennington Rodgers, biochemist David Baker explores his team’s Nobel Prize-winning work using AI to design new proteins with functions never before seen in nature — achieving breakthroughs that have fundamentally changed the future of science. (This conversation was part of an exclusive TED Membership event. TED Membership is the best way to support and engage with the big ideas you love from TED. To learn more, visit ted.com/membership.)

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Can AI compress the years long research time of a PhD into seconds? Research scientist Max Jaderberg explores how “AI analogs” simulate real-world lab work with staggering speed and scale, unlocking new insights on protein folding and drug discovery. Drawing on his experience working on Isomorphic Labs' and Google DeepMind's AlphaFold 3 — an AI model for predicting the structure of molecules — Jaderberg explains how this new technology frees up researchers' time and resources to better understand the real, messy world and tackle the next frontiers of science, medicine and more.

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In this episode, Shoshana invites Dr. Vivek Murthy, the 19th and 21st Surgeon General of the United States, to discuss the ongoing loneliness epidemic.

After the interview, Shoshana shares a TED-Ed talk from Terry Kupers, "What happens to your brain without social contact?" Everyone needs time to themselves, and peaceful solitude has stress-relieving benefits. But when being alone is forced upon you, the effects can be surprisingly extensive. And though different people experience distinct effects, symptoms tend to become more severe and persistent the longer they're isolated. So, how exactly does isolation affect your body and brain? Terry Kupers investigates. [Directed by Camille Bovey, narrated by Addison Anderson, music by Stephen LaRosa].

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Does venting actually help you cool off, or does it just add fuel to the fire? Social psychologist Jennifer Parlamis busts common myths about anger, showing how curiosity — not catharsis — can keep you calm. Discover the surprising science behind anger management and four practical tools for building stronger relationships from a researcher who’s rethinking Freud, one deep breath at a time.

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Did you know that you start losing bone AND muscle mass as soon as the age of thirty? Or that your fingers and toes don’t have muscles? Or how women in Scotland are starting to compete in the lighting of Dinnie Stones – which weighs 733 pounds?! These are topics that Chris discussed with Bonnie Tsui, author of the book On Muscle: The Stuff That Moves Us and Why It Matters. They also discuss what strength and weightlifting means in today’s society – especially as more women enter the sport. Bonnie and Chris also discuss studying martial arts, playing on sports teams, and the benefits of functional mobility as you age.

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Neuroscientist Jennifer Pfeifer digs into the fascinating brain changes driving young people’s behavior during the critical years of adolescence. She debunks some of the biggest misunderstandings about teens — including puberty, hormones and the impact of social media on mental health — and shows how to support kids during this period of growth and possibility.

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Dr. BJ Miller was a college sophomore when a sudden electrical accident nearly took his life. After months in a hospital burn unit and multiple amputations, he emerged into a world that saw him — and treated him — differently. But that experience became the foundation for everything that followed.

Now a palliative care physician and one of the most compassionate voices in medicine, BJ is redefining what it means to live fully after loss and change. He challenges the very idea of “normal,” reminding us that disability isn’t a flaw to fix, but part of the human spectrum. His work invites us to expand our imagination of what it means to be alive, to belong, and to be whole.

Join us on Instagram  for more stories, behind-the-scenes moments, and reflections on living and dying.

After the interview, Shoshana features a TED talk from Meghan Hussey on 4 Ways To Design a Disability-Friendly Future.

Join @beforewegopodcast on Instagram for more stories, behind-the-scenes moments, and reflections on living and dying.

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To spark action on climate change, the conventional wisdom says that awareness must precede action — but neuroscientist Kris De Meyer suggests the opposite is true: actions drive beliefs. He digs into the science behind decision-making and shows how you can rewire your brain to get unstuck on big challenges.

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With just a few lines, cartoons can say so much with so little. In a moving talk, cartoonist Navied Mahdavian shares his process for distilling huge concepts into drawings on the page — and shows how his work helped him grieve the death of his beloved grandmother, flaws and all.

After the talk, Shoshana interviews Nathan Gray on the use of comics and art to educate and explore the ironies of the medical world.

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Today, we’re featuring an episode from NPR’s science podcast Short Wave. In it, host Regina G. Barber talks to NPR brain correspondent Jon Hamilton about MENTAL EXERCISES. 

Scientists have found the first compelling evidence that cognitive training can boost levels of a chemical that typically declines as people age. And previous studies of people have suggested that cognitive training can improve thinking and memory. So how does it all work? And by how much does it all work? Find out with this episode of Short Wave.

Follow NPR's Short Wave podcast on Apple Podcasts and Spotify for more episodes like this, featuring new discoveries, everyday mysteries and the science behind the headlines.

Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

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